Model-Based Weaning Tests for VA-ECLS Therapy

Venoarterial extracorporeal life support (VA-ECLS) is used in ICUs (intensive care units) for the most extreme presentations of acute and severe cardiogenic shock, and one of the main issues the clinicians have to deal with is the weaning from VA-ECLS. In this study, a patient-specific model of the...

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Detalles Bibliográficos
Autores principales: Habran, Simon, Desaive, Thomas, Morimont, Philippe, Lambermont, Bernard, Dauby, Pierre C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165357/
https://www.ncbi.nlm.nih.gov/pubmed/32328151
http://dx.doi.org/10.1155/2020/4503919
Descripción
Sumario:Venoarterial extracorporeal life support (VA-ECLS) is used in ICUs (intensive care units) for the most extreme presentations of acute and severe cardiogenic shock, and one of the main issues the clinicians have to deal with is the weaning from VA-ECLS. In this study, a patient-specific model of the cardiovascular system connected to a VA-ECLS is built to improve the understanding of this complex system. Pig experiments are performed to validate the model, and the results are quite promising since the mean difference between experimental data and simulation is smaller than 5% for all the hemodynamic quantities. It is also a major objective of this paper to provide a proof-of-concept analysis that model-based approaches could improve the weaning strategy for VA-ECLS therapy.

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