Targeted remodeling of breast cancer and immune cell homing niches by exosomal integrins

Exosomes represent an important subset of extracellular vesicles involved in inter-cellular communications in health and diseases. Exosomes secreted from cancer and immune cells travel to the specific tissues containing homing niches. The exosomes reaching the niches dynamically modify the gene expr...

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Autores principales: Myint, Phyoe Kyawe, Park, Eun Jeong, Gaowa, Arong, Kawamoto, Eiji, Shimaoka, Motomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165434/
https://www.ncbi.nlm.nih.gov/pubmed/32305065
http://dx.doi.org/10.1186/s13000-020-00959-3
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author Myint, Phyoe Kyawe
Park, Eun Jeong
Gaowa, Arong
Kawamoto, Eiji
Shimaoka, Motomu
author_facet Myint, Phyoe Kyawe
Park, Eun Jeong
Gaowa, Arong
Kawamoto, Eiji
Shimaoka, Motomu
author_sort Myint, Phyoe Kyawe
collection PubMed
description Exosomes represent an important subset of extracellular vesicles involved in inter-cellular communications in health and diseases. Exosomes secreted from cancer and immune cells travel to the specific tissues containing homing niches. The exosomes reaching the niches dynamically modify the gene expression and molecular architectures of the homing niche micro-environments. Cell adhesion molecule integrins regulate the tissue-specific homing patterns of not only cancer and immune cells, but also of the exosomes secreted from those cells. The exosome-mediated remodeling of the homing niches would affect immune lymphocyte migration and host defense, as well as cancer metastasis, thereby representing a potential therapeutic target.
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spelling pubmed-71654342020-04-23 Targeted remodeling of breast cancer and immune cell homing niches by exosomal integrins Myint, Phyoe Kyawe Park, Eun Jeong Gaowa, Arong Kawamoto, Eiji Shimaoka, Motomu Diagn Pathol Commentary Exosomes represent an important subset of extracellular vesicles involved in inter-cellular communications in health and diseases. Exosomes secreted from cancer and immune cells travel to the specific tissues containing homing niches. The exosomes reaching the niches dynamically modify the gene expression and molecular architectures of the homing niche micro-environments. Cell adhesion molecule integrins regulate the tissue-specific homing patterns of not only cancer and immune cells, but also of the exosomes secreted from those cells. The exosome-mediated remodeling of the homing niches would affect immune lymphocyte migration and host defense, as well as cancer metastasis, thereby representing a potential therapeutic target. BioMed Central 2020-04-18 /pmc/articles/PMC7165434/ /pubmed/32305065 http://dx.doi.org/10.1186/s13000-020-00959-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Commentary
Myint, Phyoe Kyawe
Park, Eun Jeong
Gaowa, Arong
Kawamoto, Eiji
Shimaoka, Motomu
Targeted remodeling of breast cancer and immune cell homing niches by exosomal integrins
title Targeted remodeling of breast cancer and immune cell homing niches by exosomal integrins
title_full Targeted remodeling of breast cancer and immune cell homing niches by exosomal integrins
title_fullStr Targeted remodeling of breast cancer and immune cell homing niches by exosomal integrins
title_full_unstemmed Targeted remodeling of breast cancer and immune cell homing niches by exosomal integrins
title_short Targeted remodeling of breast cancer and immune cell homing niches by exosomal integrins
title_sort targeted remodeling of breast cancer and immune cell homing niches by exosomal integrins
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165434/
https://www.ncbi.nlm.nih.gov/pubmed/32305065
http://dx.doi.org/10.1186/s13000-020-00959-3
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