Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms

Coronavirus disease 2019 (COVID-19) is a pandemic that has affected more than 1.8 million people worldwide, overwhelmed health care systems owing to the high proportion of critical presentations, and resulted in more than 100,000 deaths. Since the first data analyses in China, elevated cardiac tropo...

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Autores principales: Tersalvi, Gregorio, Vicenzi, Marco, Calabretta, Davide, Biasco, Luigi, Pedrazzini, Giovanni, Winterton, Dario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166030/
https://www.ncbi.nlm.nih.gov/pubmed/32315733
http://dx.doi.org/10.1016/j.cardfail.2020.04.009
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author Tersalvi, Gregorio
Vicenzi, Marco
Calabretta, Davide
Biasco, Luigi
Pedrazzini, Giovanni
Winterton, Dario
author_facet Tersalvi, Gregorio
Vicenzi, Marco
Calabretta, Davide
Biasco, Luigi
Pedrazzini, Giovanni
Winterton, Dario
author_sort Tersalvi, Gregorio
collection PubMed
description Coronavirus disease 2019 (COVID-19) is a pandemic that has affected more than 1.8 million people worldwide, overwhelmed health care systems owing to the high proportion of critical presentations, and resulted in more than 100,000 deaths. Since the first data analyses in China, elevated cardiac troponin has been noted in a substantial proportion of patients, implicating myocardial injury as a possible pathogenic mechanism contributing to severe illness and mortality. Accordingly, high troponin levels are associated with increased mortality in patients with COVID-19. This brief review explores the available evidence regarding the association between COVID-19 and myocardial injury.
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spelling pubmed-71660302020-04-20 Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms Tersalvi, Gregorio Vicenzi, Marco Calabretta, Davide Biasco, Luigi Pedrazzini, Giovanni Winterton, Dario J Card Fail Article Coronavirus disease 2019 (COVID-19) is a pandemic that has affected more than 1.8 million people worldwide, overwhelmed health care systems owing to the high proportion of critical presentations, and resulted in more than 100,000 deaths. Since the first data analyses in China, elevated cardiac troponin has been noted in a substantial proportion of patients, implicating myocardial injury as a possible pathogenic mechanism contributing to severe illness and mortality. Accordingly, high troponin levels are associated with increased mortality in patients with COVID-19. This brief review explores the available evidence regarding the association between COVID-19 and myocardial injury. Elsevier Inc. 2020-06 2020-04-18 /pmc/articles/PMC7166030/ /pubmed/32315733 http://dx.doi.org/10.1016/j.cardfail.2020.04.009 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Tersalvi, Gregorio
Vicenzi, Marco
Calabretta, Davide
Biasco, Luigi
Pedrazzini, Giovanni
Winterton, Dario
Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms
title Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms
title_full Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms
title_fullStr Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms
title_full_unstemmed Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms
title_short Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms
title_sort elevated troponin in patients with coronavirus disease 2019: possible mechanisms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166030/
https://www.ncbi.nlm.nih.gov/pubmed/32315733
http://dx.doi.org/10.1016/j.cardfail.2020.04.009
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