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Quinonoids: Therapeutic Potential for Lung Cancer Treatment

Lung cancer is the leading cause of cancer-related deaths worldwide. Owing to its high incidence and mortality, the development and discovery of novel anticancer drugs is of great importance. In recent years, many breakthroughs have been achieved in the search for effective anticancer substances fro...

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Autores principales: Ying, Hua-Zhong, Yu, Chen-Huan, Chen, Hao-Kun, Zhang, Huan-Huan, Fang, Jie, Wu, Fang, Yu, Wen-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166295/
https://www.ncbi.nlm.nih.gov/pubmed/32337232
http://dx.doi.org/10.1155/2020/2460565
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author Ying, Hua-Zhong
Yu, Chen-Huan
Chen, Hao-Kun
Zhang, Huan-Huan
Fang, Jie
Wu, Fang
Yu, Wen-Ying
author_facet Ying, Hua-Zhong
Yu, Chen-Huan
Chen, Hao-Kun
Zhang, Huan-Huan
Fang, Jie
Wu, Fang
Yu, Wen-Ying
author_sort Ying, Hua-Zhong
collection PubMed
description Lung cancer is the leading cause of cancer-related deaths worldwide. Owing to its high incidence and mortality, the development and discovery of novel anticancer drugs is of great importance. In recent years, many breakthroughs have been achieved in the search for effective anticancer substances from natural products. Many anticancer drugs used clinically and proven to be effective are derived from natural products. Quinonoids, including naphthoquinones, phenanthrenequinones, benzoquinones, and anthraquinones, constitute a large group of natural bioactive compounds that widely exist in higher and lower plant species. Given that most of these compounds possess anticancer effects, they are applied in many cancer studies, especially in lung cancer research. They can promote apoptosis, induce autophagy, and inhibit proliferation, angiogenesis, and cell invasion and migration. Some drugs can enhance anticancer effects when combined with other drugs. Thus, quinonoids have broad application prospects in the treatment of lung cancer. Here, we summarize the previous studies on the antilung cancer activities of quinonoids together with their underlying mechanisms and analyze the common research targets with different effects so as to provide references for the discovery of quinonoids against lung cancer.
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spelling pubmed-71662952020-04-24 Quinonoids: Therapeutic Potential for Lung Cancer Treatment Ying, Hua-Zhong Yu, Chen-Huan Chen, Hao-Kun Zhang, Huan-Huan Fang, Jie Wu, Fang Yu, Wen-Ying Biomed Res Int Review Article Lung cancer is the leading cause of cancer-related deaths worldwide. Owing to its high incidence and mortality, the development and discovery of novel anticancer drugs is of great importance. In recent years, many breakthroughs have been achieved in the search for effective anticancer substances from natural products. Many anticancer drugs used clinically and proven to be effective are derived from natural products. Quinonoids, including naphthoquinones, phenanthrenequinones, benzoquinones, and anthraquinones, constitute a large group of natural bioactive compounds that widely exist in higher and lower plant species. Given that most of these compounds possess anticancer effects, they are applied in many cancer studies, especially in lung cancer research. They can promote apoptosis, induce autophagy, and inhibit proliferation, angiogenesis, and cell invasion and migration. Some drugs can enhance anticancer effects when combined with other drugs. Thus, quinonoids have broad application prospects in the treatment of lung cancer. Here, we summarize the previous studies on the antilung cancer activities of quinonoids together with their underlying mechanisms and analyze the common research targets with different effects so as to provide references for the discovery of quinonoids against lung cancer. Hindawi 2020-04-06 /pmc/articles/PMC7166295/ /pubmed/32337232 http://dx.doi.org/10.1155/2020/2460565 Text en Copyright © 2020 Hua-Zhong Ying et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ying, Hua-Zhong
Yu, Chen-Huan
Chen, Hao-Kun
Zhang, Huan-Huan
Fang, Jie
Wu, Fang
Yu, Wen-Ying
Quinonoids: Therapeutic Potential for Lung Cancer Treatment
title Quinonoids: Therapeutic Potential for Lung Cancer Treatment
title_full Quinonoids: Therapeutic Potential for Lung Cancer Treatment
title_fullStr Quinonoids: Therapeutic Potential for Lung Cancer Treatment
title_full_unstemmed Quinonoids: Therapeutic Potential for Lung Cancer Treatment
title_short Quinonoids: Therapeutic Potential for Lung Cancer Treatment
title_sort quinonoids: therapeutic potential for lung cancer treatment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166295/
https://www.ncbi.nlm.nih.gov/pubmed/32337232
http://dx.doi.org/10.1155/2020/2460565
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