Cargando…

Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis

BACKGROUND: In this systematic review and meta-analysis, we aimed to explore the association between cardiac injury and mortality, the need for intensive care unit (ICU) care, acute respiratory distress syndrome (ARDS), and severe coronavirus disease 2019 (COVID-19) in patients with COVID-19 pneumon...

Descripción completa

Detalles Bibliográficos
Autores principales: Santoso, Anwar, Pranata, Raymond, Wibowo, Arief, Al-Farabi, Makhyan Jibril, Huang, Ian, Antariksa, Budhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166308/
https://www.ncbi.nlm.nih.gov/pubmed/32331955
http://dx.doi.org/10.1016/j.ajem.2020.04.052
_version_ 1783523533872168960
author Santoso, Anwar
Pranata, Raymond
Wibowo, Arief
Al-Farabi, Makhyan Jibril
Huang, Ian
Antariksa, Budhi
author_facet Santoso, Anwar
Pranata, Raymond
Wibowo, Arief
Al-Farabi, Makhyan Jibril
Huang, Ian
Antariksa, Budhi
author_sort Santoso, Anwar
collection PubMed
description BACKGROUND: In this systematic review and meta-analysis, we aimed to explore the association between cardiac injury and mortality, the need for intensive care unit (ICU) care, acute respiratory distress syndrome (ARDS), and severe coronavirus disease 2019 (COVID-19) in patients with COVID-19 pneumonia. METHODS: We performed a comprehensive literature search from several databases. Definition of cardiac injury follows that of the included studies, which includes highly sensitive cardiac troponin I (hs-cTnl) >99th percentile.The primary outcome was mortality, and the secondary outcomes were ARDS, the need for ICU care, and severe COVID-19. ARDS and severe COVID-19 were defined per the World Health Organization (WHO) interim guidance of severe acute respiratory infection (SARI) of COVID-19. RESULTS: There were a total of 2389 patients from 13 studies. This meta-analysis showed that cardiac injury was associated with higher mortality (RR 7.95 [5.12, 12.34], p < 0.001; I(2): 65%). Cardiac injury was associated with higher need for ICU care (RR 7.94 [1.51, 41.78], p = 0.01; I(2): 79%), and severe COVID-19 (RR 13.81 [5.52, 34.52], p < 0.001; I(2): 0%). The cardiac injury was not significant for increased risk of ARDS (RR 2.57 [0.96, 6.85], p = 0.06; I(2): 84%). The level of hs-cTnI was higher in patients with primary + secondary outcome (mean difference 10.38 pg/mL [4.44, 16.32], p = 0.002; I(2): 0%). CONCLUSION: Cardiac injury is associated with mortality, need for ICU care, and severity of disease in patients with COVID-19.
format Online
Article
Text
id pubmed-7166308
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier Inc.
record_format MEDLINE/PubMed
spelling pubmed-71663082020-04-20 Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis Santoso, Anwar Pranata, Raymond Wibowo, Arief Al-Farabi, Makhyan Jibril Huang, Ian Antariksa, Budhi Am J Emerg Med Article BACKGROUND: In this systematic review and meta-analysis, we aimed to explore the association between cardiac injury and mortality, the need for intensive care unit (ICU) care, acute respiratory distress syndrome (ARDS), and severe coronavirus disease 2019 (COVID-19) in patients with COVID-19 pneumonia. METHODS: We performed a comprehensive literature search from several databases. Definition of cardiac injury follows that of the included studies, which includes highly sensitive cardiac troponin I (hs-cTnl) >99th percentile.The primary outcome was mortality, and the secondary outcomes were ARDS, the need for ICU care, and severe COVID-19. ARDS and severe COVID-19 were defined per the World Health Organization (WHO) interim guidance of severe acute respiratory infection (SARI) of COVID-19. RESULTS: There were a total of 2389 patients from 13 studies. This meta-analysis showed that cardiac injury was associated with higher mortality (RR 7.95 [5.12, 12.34], p < 0.001; I(2): 65%). Cardiac injury was associated with higher need for ICU care (RR 7.94 [1.51, 41.78], p = 0.01; I(2): 79%), and severe COVID-19 (RR 13.81 [5.52, 34.52], p < 0.001; I(2): 0%). The cardiac injury was not significant for increased risk of ARDS (RR 2.57 [0.96, 6.85], p = 0.06; I(2): 84%). The level of hs-cTnI was higher in patients with primary + secondary outcome (mean difference 10.38 pg/mL [4.44, 16.32], p = 0.002; I(2): 0%). CONCLUSION: Cardiac injury is associated with mortality, need for ICU care, and severity of disease in patients with COVID-19. Elsevier Inc. 2021-06 2020-04-19 /pmc/articles/PMC7166308/ /pubmed/32331955 http://dx.doi.org/10.1016/j.ajem.2020.04.052 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Santoso, Anwar
Pranata, Raymond
Wibowo, Arief
Al-Farabi, Makhyan Jibril
Huang, Ian
Antariksa, Budhi
Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis
title Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis
title_full Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis
title_fullStr Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis
title_full_unstemmed Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis
title_short Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis
title_sort cardiac injury is associated with mortality and critically ill pneumonia in covid-19: a meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166308/
https://www.ncbi.nlm.nih.gov/pubmed/32331955
http://dx.doi.org/10.1016/j.ajem.2020.04.052
work_keys_str_mv AT santosoanwar cardiacinjuryisassociatedwithmortalityandcriticallyillpneumoniaincovid19ametaanalysis
AT pranataraymond cardiacinjuryisassociatedwithmortalityandcriticallyillpneumoniaincovid19ametaanalysis
AT wibowoarief cardiacinjuryisassociatedwithmortalityandcriticallyillpneumoniaincovid19ametaanalysis
AT alfarabimakhyanjibril cardiacinjuryisassociatedwithmortalityandcriticallyillpneumoniaincovid19ametaanalysis
AT huangian cardiacinjuryisassociatedwithmortalityandcriticallyillpneumoniaincovid19ametaanalysis
AT antariksabudhi cardiacinjuryisassociatedwithmortalityandcriticallyillpneumoniaincovid19ametaanalysis