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Ivacaftor decreases monocyte sensitivity to interferon-γ in people with cystic fibrosis
This study demonstrates that initiation of the CFTR modulator ivacaftor in people with cystic fibrosis and susceptible CFTR mutations causes an acute reduction in blood monocyte sensitivity to the key proinflammatory cytokine IFN-γ http://bit.ly/2TeI6LG
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
European Respiratory Society
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167213/ https://www.ncbi.nlm.nih.gov/pubmed/32337217 http://dx.doi.org/10.1183/23120541.00318-2019 |
| _version_ | 1783523537135337472 |
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| author | Hisert, Katherine B. Birkland, Timothy P. Schoenfelt, Kelly Q. Long, Matthew E. Grogan, Brenda Carter, Suzanne Liles, W. Conrad McKone, Edward F. Becker, Lev Manicone, Anne M. |
| author_facet | Hisert, Katherine B. Birkland, Timothy P. Schoenfelt, Kelly Q. Long, Matthew E. Grogan, Brenda Carter, Suzanne Liles, W. Conrad McKone, Edward F. Becker, Lev Manicone, Anne M. |
| author_sort | Hisert, Katherine B. |
| collection | PubMed |
| description | This study demonstrates that initiation of the CFTR modulator ivacaftor in people with cystic fibrosis and susceptible CFTR mutations causes an acute reduction in blood monocyte sensitivity to the key proinflammatory cytokine IFN-γ http://bit.ly/2TeI6LG |
| format | Online Article Text |
| id | pubmed-7167213 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | European Respiratory Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-71672132020-04-24 Ivacaftor decreases monocyte sensitivity to interferon-γ in people with cystic fibrosis Hisert, Katherine B. Birkland, Timothy P. Schoenfelt, Kelly Q. Long, Matthew E. Grogan, Brenda Carter, Suzanne Liles, W. Conrad McKone, Edward F. Becker, Lev Manicone, Anne M. ERJ Open Res Original Research Letters This study demonstrates that initiation of the CFTR modulator ivacaftor in people with cystic fibrosis and susceptible CFTR mutations causes an acute reduction in blood monocyte sensitivity to the key proinflammatory cytokine IFN-γ http://bit.ly/2TeI6LG European Respiratory Society 2020-04-19 /pmc/articles/PMC7167213/ /pubmed/32337217 http://dx.doi.org/10.1183/23120541.00318-2019 Text en Copyright ©ERS 2020 http://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. |
| spellingShingle | Original Research Letters Hisert, Katherine B. Birkland, Timothy P. Schoenfelt, Kelly Q. Long, Matthew E. Grogan, Brenda Carter, Suzanne Liles, W. Conrad McKone, Edward F. Becker, Lev Manicone, Anne M. Ivacaftor decreases monocyte sensitivity to interferon-γ in people with cystic fibrosis |
| title | Ivacaftor decreases monocyte sensitivity to interferon-γ in people with cystic fibrosis |
| title_full | Ivacaftor decreases monocyte sensitivity to interferon-γ in people with cystic fibrosis |
| title_fullStr | Ivacaftor decreases monocyte sensitivity to interferon-γ in people with cystic fibrosis |
| title_full_unstemmed | Ivacaftor decreases monocyte sensitivity to interferon-γ in people with cystic fibrosis |
| title_short | Ivacaftor decreases monocyte sensitivity to interferon-γ in people with cystic fibrosis |
| title_sort | ivacaftor decreases monocyte sensitivity to interferon-γ in people with cystic fibrosis |
| topic | Original Research Letters |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167213/ https://www.ncbi.nlm.nih.gov/pubmed/32337217 http://dx.doi.org/10.1183/23120541.00318-2019 |
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