The use of 5‐fluorouracil in the prevention of tendon adhesions: A systematic review

BACKGROUND: This systematic review aims to study the effectiveness of 5‐fluorouracil (5FU) in the reduction of tendon adhesions postsurgical repair. METHOD: A systematic review was performed involving four databases, Cochrane, PubMed, MEDLINE, and Embase, looking for evidence of at least Level I or...

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Detalles Bibliográficos
Autores principales: Nazifi, Omid, Stuart, Andrew L., Nikkhah, Dariush
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167231/
https://www.ncbi.nlm.nih.gov/pubmed/32318664
http://dx.doi.org/10.1002/ame2.12110
Descripción
Sumario:BACKGROUND: This systematic review aims to study the effectiveness of 5‐fluorouracil (5FU) in the reduction of tendon adhesions postsurgical repair. METHOD: A systematic review was performed involving four databases, Cochrane, PubMed, MEDLINE, and Embase, looking for evidence of at least Level I or Level II (according to NHMRC) in the use of 5FU in tendon repairs in human or animal studies. RESULTS: Across the four databases 546 articles were identified. Of these 12 were identified as relevant, with a further two being excluded after in depth review. CONCLUSIONS: Nine of the 10 studies showed that 5FU was effective at reducing tendon adhesions in their respective animal studies. One of the 10 studies showed no significant change compared to the control group.

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