The use of 5‐fluorouracil in the prevention of tendon adhesions: A systematic review

BACKGROUND: This systematic review aims to study the effectiveness of 5‐fluorouracil (5FU) in the reduction of tendon adhesions postsurgical repair. METHOD: A systematic review was performed involving four databases, Cochrane, PubMed, MEDLINE, and Embase, looking for evidence of at least Level I or...

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Autores principales: Nazifi, Omid, Stuart, Andrew L., Nikkhah, Dariush
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167231/
https://www.ncbi.nlm.nih.gov/pubmed/32318664
http://dx.doi.org/10.1002/ame2.12110
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author Nazifi, Omid
Stuart, Andrew L.
Nikkhah, Dariush
author_facet Nazifi, Omid
Stuart, Andrew L.
Nikkhah, Dariush
author_sort Nazifi, Omid
collection PubMed
description BACKGROUND: This systematic review aims to study the effectiveness of 5‐fluorouracil (5FU) in the reduction of tendon adhesions postsurgical repair. METHOD: A systematic review was performed involving four databases, Cochrane, PubMed, MEDLINE, and Embase, looking for evidence of at least Level I or Level II (according to NHMRC) in the use of 5FU in tendon repairs in human or animal studies. RESULTS: Across the four databases 546 articles were identified. Of these 12 were identified as relevant, with a further two being excluded after in depth review. CONCLUSIONS: Nine of the 10 studies showed that 5FU was effective at reducing tendon adhesions in their respective animal studies. One of the 10 studies showed no significant change compared to the control group.
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spelling pubmed-71672312020-04-21 The use of 5‐fluorouracil in the prevention of tendon adhesions: A systematic review Nazifi, Omid Stuart, Andrew L. Nikkhah, Dariush Animal Model Exp Med Original Articles BACKGROUND: This systematic review aims to study the effectiveness of 5‐fluorouracil (5FU) in the reduction of tendon adhesions postsurgical repair. METHOD: A systematic review was performed involving four databases, Cochrane, PubMed, MEDLINE, and Embase, looking for evidence of at least Level I or Level II (according to NHMRC) in the use of 5FU in tendon repairs in human or animal studies. RESULTS: Across the four databases 546 articles were identified. Of these 12 were identified as relevant, with a further two being excluded after in depth review. CONCLUSIONS: Nine of the 10 studies showed that 5FU was effective at reducing tendon adhesions in their respective animal studies. One of the 10 studies showed no significant change compared to the control group. John Wiley and Sons Inc. 2020-04-03 /pmc/articles/PMC7167231/ /pubmed/32318664 http://dx.doi.org/10.1002/ame2.12110 Text en © 2020 The Authors. Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Nazifi, Omid
Stuart, Andrew L.
Nikkhah, Dariush
The use of 5‐fluorouracil in the prevention of tendon adhesions: A systematic review
title The use of 5‐fluorouracil in the prevention of tendon adhesions: A systematic review
title_full The use of 5‐fluorouracil in the prevention of tendon adhesions: A systematic review
title_fullStr The use of 5‐fluorouracil in the prevention of tendon adhesions: A systematic review
title_full_unstemmed The use of 5‐fluorouracil in the prevention of tendon adhesions: A systematic review
title_short The use of 5‐fluorouracil in the prevention of tendon adhesions: A systematic review
title_sort use of 5‐fluorouracil in the prevention of tendon adhesions: a systematic review
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167231/
https://www.ncbi.nlm.nih.gov/pubmed/32318664
http://dx.doi.org/10.1002/ame2.12110
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