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Age‐related rhesus macaque models of COVID‐19

BACKGROUND: Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) in Wuhan, China, has become a public health emergency of international concern. The high fatality of aged cases caused by SARS‐CoV‐2 was a nee...

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Autores principales: Yu, Pin, Qi, Feifei, Xu, Yanfeng, Li, Fengdi, Liu, Peipei, Liu, Jiayi, Bao, Linlin, Deng, Wei, Gao, Hong, Xiang, Zhiguang, Xiao, Chong, Lv, Qi, Gong, Shuran, Liu, Jiangning, Song, Zhiqi, Qu, Yajin, Xue, Jing, Wei, Qiang, Liu, Mingya, Wang, Guanpeng, Wang, Shunyi, Yu, Haisheng, Liu, Xing, Huang, Baoying, Wang, Wenling, Zhao, Li, Wang, Huijuan, Ye, Fei, Zhou, Weimin, Zhen, Wei, Han, Jun, Wu, Guizhen, Jin, Qi, Wang, Jianwei, Tan, Wenjie, Qin, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167234/
https://www.ncbi.nlm.nih.gov/pubmed/32318665
http://dx.doi.org/10.1002/ame2.12108
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author Yu, Pin
Qi, Feifei
Xu, Yanfeng
Li, Fengdi
Liu, Peipei
Liu, Jiayi
Bao, Linlin
Deng, Wei
Gao, Hong
Xiang, Zhiguang
Xiao, Chong
Lv, Qi
Gong, Shuran
Liu, Jiangning
Song, Zhiqi
Qu, Yajin
Xue, Jing
Wei, Qiang
Liu, Mingya
Wang, Guanpeng
Wang, Shunyi
Yu, Haisheng
Liu, Xing
Huang, Baoying
Wang, Wenling
Zhao, Li
Wang, Huijuan
Ye, Fei
Zhou, Weimin
Zhen, Wei
Han, Jun
Wu, Guizhen
Jin, Qi
Wang, Jianwei
Tan, Wenjie
Qin, Chuan
author_facet Yu, Pin
Qi, Feifei
Xu, Yanfeng
Li, Fengdi
Liu, Peipei
Liu, Jiayi
Bao, Linlin
Deng, Wei
Gao, Hong
Xiang, Zhiguang
Xiao, Chong
Lv, Qi
Gong, Shuran
Liu, Jiangning
Song, Zhiqi
Qu, Yajin
Xue, Jing
Wei, Qiang
Liu, Mingya
Wang, Guanpeng
Wang, Shunyi
Yu, Haisheng
Liu, Xing
Huang, Baoying
Wang, Wenling
Zhao, Li
Wang, Huijuan
Ye, Fei
Zhou, Weimin
Zhen, Wei
Han, Jun
Wu, Guizhen
Jin, Qi
Wang, Jianwei
Tan, Wenjie
Qin, Chuan
author_sort Yu, Pin
collection PubMed
description BACKGROUND: Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) in Wuhan, China, has become a public health emergency of international concern. The high fatality of aged cases caused by SARS‐CoV‐2 was a need to explore the possible age‐related phenomena with non‐human primate models. METHODS: Three 3‐5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS‐CoV‐2, and then analyzed by clinical signs, viral replication, chest X‐ray, histopathological changes and immune response. RESULTS: Viral replication of nasopharyngeal swabs, anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS‐CoV‐2 challenge. Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema, notably, old monkeys exhibited diffuse severe interstitial pneumonia. Viral antigens were detected mainly in alveolar epithelial cells and macrophages. CONCLUSION: SARS‐CoV‐2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS‐CoV‐2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS‐CoV‐2 infection.
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spelling pubmed-71672342020-04-21 Age‐related rhesus macaque models of COVID‐19 Yu, Pin Qi, Feifei Xu, Yanfeng Li, Fengdi Liu, Peipei Liu, Jiayi Bao, Linlin Deng, Wei Gao, Hong Xiang, Zhiguang Xiao, Chong Lv, Qi Gong, Shuran Liu, Jiangning Song, Zhiqi Qu, Yajin Xue, Jing Wei, Qiang Liu, Mingya Wang, Guanpeng Wang, Shunyi Yu, Haisheng Liu, Xing Huang, Baoying Wang, Wenling Zhao, Li Wang, Huijuan Ye, Fei Zhou, Weimin Zhen, Wei Han, Jun Wu, Guizhen Jin, Qi Wang, Jianwei Tan, Wenjie Qin, Chuan Animal Model Exp Med Short Communications BACKGROUND: Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) in Wuhan, China, has become a public health emergency of international concern. The high fatality of aged cases caused by SARS‐CoV‐2 was a need to explore the possible age‐related phenomena with non‐human primate models. METHODS: Three 3‐5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS‐CoV‐2, and then analyzed by clinical signs, viral replication, chest X‐ray, histopathological changes and immune response. RESULTS: Viral replication of nasopharyngeal swabs, anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS‐CoV‐2 challenge. Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema, notably, old monkeys exhibited diffuse severe interstitial pneumonia. Viral antigens were detected mainly in alveolar epithelial cells and macrophages. CONCLUSION: SARS‐CoV‐2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS‐CoV‐2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS‐CoV‐2 infection. John Wiley and Sons Inc. 2020-03-30 /pmc/articles/PMC7167234/ /pubmed/32318665 http://dx.doi.org/10.1002/ame2.12108 Text en © 2020 The Authors. Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Short Communications
Yu, Pin
Qi, Feifei
Xu, Yanfeng
Li, Fengdi
Liu, Peipei
Liu, Jiayi
Bao, Linlin
Deng, Wei
Gao, Hong
Xiang, Zhiguang
Xiao, Chong
Lv, Qi
Gong, Shuran
Liu, Jiangning
Song, Zhiqi
Qu, Yajin
Xue, Jing
Wei, Qiang
Liu, Mingya
Wang, Guanpeng
Wang, Shunyi
Yu, Haisheng
Liu, Xing
Huang, Baoying
Wang, Wenling
Zhao, Li
Wang, Huijuan
Ye, Fei
Zhou, Weimin
Zhen, Wei
Han, Jun
Wu, Guizhen
Jin, Qi
Wang, Jianwei
Tan, Wenjie
Qin, Chuan
Age‐related rhesus macaque models of COVID‐19
title Age‐related rhesus macaque models of COVID‐19
title_full Age‐related rhesus macaque models of COVID‐19
title_fullStr Age‐related rhesus macaque models of COVID‐19
title_full_unstemmed Age‐related rhesus macaque models of COVID‐19
title_short Age‐related rhesus macaque models of COVID‐19
title_sort age‐related rhesus macaque models of covid‐19
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167234/
https://www.ncbi.nlm.nih.gov/pubmed/32318665
http://dx.doi.org/10.1002/ame2.12108
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