Cargando…

Pumpkin Oil–Based Nanostructured Lipid Carrier System for Antiulcer Effect in NSAID-Induced Gastric Ulcer Model in Rats

BACKGROUND: Peptic ulcer disease, a painful lesion of the gastric mucosa, is considered one of the most common gastrointestinal disorders. This study aims to investigate the formulation of pumpkin seed oil (PSO)-based nanostructured lipid carriers (NLCs) to utilize PSO as the liquid lipid component...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahmed, Osama A A, Fahmy, Usama A, Bakhaidar, Rana, El-Moselhy, Mohamed A, Alfaleh, Mohamed A, Ahmed, Al-Shaimaa F, Hammad, Asmaa S A, Aldawsari, Hibah, Alhakamy, Nabil A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167276/ https://www.ncbi.nlm.nih.gov/pubmed/32346290 http://dx.doi.org/10.2147/IJN.S247252

Ejemplares similares

Omega-3 Self-Nanoemulsion Role in Gastroprotection against Indomethacin-Induced Gastric Injury in Rats
por: Ahmed, Osama A. A., et al.
Publicado: (2020)

Optimized Self-Nanoemulsifying Delivery System Based on Plant-Derived Oil Augments Alpha-Lipoic Acid Protective Effects Against Experimentally Induced Gastric Lesions
por: Badr-Eldin, Shaimaa M., et al.
Publicado: (2021)

Attenuation of Benign Prostatic Hyperplasia by Optimized Tadalafil Loaded Pumpkin Seed Oil-Based Self Nanoemulsion: In Vitro and In Vivo Evaluation
por: Alhakamy, Nabil A., et al.
Publicado: (2019)

Lipidic Nano-Sized Emulsomes Potentiates the Cytotoxic and Apoptotic Effects of Raloxifene Hydrochloride in MCF-7 Human Breast Cancer Cells: Factorial Analysis and In Vitro Anti-Tumor Activity Assessment
por: Aldawsari, Hibah M., et al.
Publicado: (2021)

Green Nanoemulsion Stabilized by In Situ Self-Assembled Natural Oil/Native Cyclodextrin Complexes: An Eco-Friendly Approach for Enhancing Anticancer Activity of Costunolide against Lung Cancer Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2022)

Scorpion Venom-Functionalized Quercetin Phytosomes for Breast Cancer Management: In Vitro Response Surface Optimization and Anticancer Activity against MCF-7 Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2021)

Pumpkin Oil–Based Nanostructured Lipid Carrier System for Antiulcer Effect in NSAID-Induced Gastric Ulcer Model in Rats [Retraction]
Publicado: (2023)

Gum Acacia Functionalized Colloidal Gold Nanoparticles of Letrozole as Biocompatible Drug Delivery Carrier for Treatment of Breast Cancer
por: Aldawsari, Hibah M., et al.
Publicado: (2021)

Hybrid nanoparticulate system of Fluvastatin loaded phospholipid, alpha lipoic acid and melittin for the management of colon cancer
por: Alfaleh, Mohamed A., et al.
Publicado: (2022)

Optimized Nanostructured Lipid Carriers Integrated into In Situ Nasal Gel for Enhancing Brain Delivery of Flibanserin
por: Fahmy, Usama A, et al.
Publicado: (2020)

The Encapsulation of Febuxostat into Emulsomes Strongly Enhances the Cytotoxic Potential of the Drug on HCT 116 Colon Cancer Cells
por: Fahmy, Usama A., et al.
Publicado: (2020)

Formulation Design, Statistical Optimization, and In Vitro Evaluation of a Naringenin Nanoemulsion to Enhance Apoptotic Activity in A549 Lung Cancer Cells
por: Md, Shadab, et al.
Publicado: (2020)

Development of an Icariin-Loaded Bilosome-Melittin Formulation with Improved Anticancer Activity against Cancerous Pancreatic Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2021)

Adenosine Conjugated Docetaxel Nanoparticles—Proof of Concept Studies for Non-Small Cell Lung Cancer
por: Aldawsari, Hibah M., et al.
Publicado: (2022)

Optimized Apamin-Mediated Nano-Lipidic Carrier Potentially Enhances the Cytotoxicity of Ellagic Acid against Human Breast Cancer Cells
por: Badr-Eldin, Shaimaa M., et al.
Publicado: (2022)

Optimized Ellagic Acid–Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats
por: Alhakamy, Nabil A., et al.
Publicado: (2020)

Evaluation of the Antiviral Activity of Sitagliptin-Glatiramer Acetate Nano-Conjugates against SARS-CoV-2 Virus
por: Alhakamy, Nabil A., et al.
Publicado: (2021)

Encapsulation of Lovastatin in Zein Nanoparticles Exhibits Enhanced Apoptotic Activity in HepG2 Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2019)

Potentiality of raloxifene loaded melittin functionalized lipidic nanovesicles against pancreatic cancer cells
por: Fahmy, Usama A., et al.
Publicado: (2022)

Formulation and Optimization of Avanafil Biodegradable Polymeric Nanoparticles: A Single-Dose Clinical Pharmacokinetic Evaluation
por: Aldawsari, Hibah M., et al.
Publicado: (2020)

Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2020)

2-Methoxyestradiol TPGS Micelles Attenuate Cyclosporine A-Induced Nephrotoxicity in Rats through Inhibition of TGF-β1 and p-ERK1/2 Axis
por: Al-Rabia, Mohammed W., et al.
Publicado: (2022)

Intranasal Niosomal In Situ Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and Ex Vivo/In Vivo Evaluation
por: Fahmy, Usama A., et al.
Publicado: (2020)

Thymoquinone-Loaded Soy-Phospholipid-Based Phytosomes Exhibit Anticancer Potential against Human Lung Cancer Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2020)

Merging Experimental Design and Nanotechnology for the Development of Optimized Simvastatin Spanlastics: A Promising Combined Strategy for Augmenting the Suppression of Various Human Cancer Cells
por: Badr-Eldin, Shaimaa M., et al.
Publicado: (2022)

Vitamin E TPGS based transferosomes augmented TAT as a promising delivery system for improved transdermal delivery of raloxifene
por: Alhakamy, Nabil A., et al.
Publicado: (2019)

Adverse Events and Tolerability of Combined Durvalumab and Tremelimumab versus Durvalumab Alone in Solid Cancers: A Systematic Review and Meta-Analysis
por: Fahmy, Omar, et al.
Publicado: (2022)

Spanlastics as a Potential Platform for Enhancing the Brain Delivery of Flibanserin: In Vitro Response-Surface Optimization and In Vivo Pharmacokinetics Assessment
por: Alharbi, Waleed S., et al.
Publicado: (2022)

Application of Nanopharmaceutics for Flibanserin Brain Delivery Augmentation Via the Nasal Route
por: Ahmed, Osama A. A., et al.
Publicado: (2020)

Development and In Vitro Evaluation of 2-Methoxyestradiol Loaded Polymeric Micelles for Enhancing Anticancer Activities in Prostate Cancer
por: Alhakamy, Nabil A., et al.
Publicado: (2021)

Apamin-Conjugated Alendronate Sodium Nanocomplex for Management of Pancreatic Cancer
por: Alhakamy, Nabil A., et al.
Publicado: (2021)

Mastoparan, a Peptide Toxin from Wasp Venom Conjugated Fluvastatin Nanocomplex for Suppression of Lung Cancer Cell Growth
por: Alhakamy, Nabil A., et al.
Publicado: (2021)

Cytotoxic and Pro-Apoptotic Effects of a Sub-Toxic Concentration of Fluvastatin on OVCAR3 Ovarian Cancer Cells After its Optimized Formulation to Melittin Nano-Conjugates
por: Badr-Eldin, Shaimaa M., et al.
Publicado: (2021)

Wasp venom peptide improves the proapoptotic activity of alendronate sodium in A549 lung cancer cells
por: Alhakamy, Nabil A., et al.
Publicado: (2022)

Optimized 2-methoxyestradiol invasomes fortified with apamin: a promising approach for suppression of A549 lung cancer cells
por: Awan, Zuhier A., et al.
Publicado: (2022)

Antiulcer secondary metabolites from Elaeocarpus grandis, family Elaeocarpaceae, supported by in silico studies
por: Mohie El-Dien, Radwa Taher, et al.
Publicado: (2020)

Development of omega-3 loxoprofen-loaded nanoemulsion to limit the side effect associated with NSAIDs in treatment of tooth pain
por: Hosny, Khaled M., et al.
Publicado: (2021)

Amitriptyline-Based Biodegradable PEG-PLGA Self-Assembled Nanoparticles Accelerate Cutaneous Wound Healing in Diabetic Rats
por: Asfour, Hani Z., et al.
Publicado: (2022)

Piceatannol-Loaded Emulsomes Exhibit Enhanced Cytostatic and Apoptotic Activities in Colon Cancer Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2020)

Development and optimization of a tamsulosin nanostructured lipid carrier loaded with saw palmetto oil and pumpkin seed oil for treatment of benign prostatic hyperplasia
por: Bakhaidar, Rana B., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_anj1eicunk9cre8im9of9hv9jk