Cargando…

Unlocking the therapeutic potential of artificial metalloenzymes

In order to harness the functionality of metals, nature has evolved over billions of years to utilize metalloproteins as key components in numerous cellular processes. Despite this, transition metals such as ruthenium, palladium, iridium, and gold are largely absent from naturally occurring metallop...

Descripción completa

Detalles Bibliográficos
Autores principales: TANAKA, Katsunori, VONG, Kenward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Academy 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167364/
https://www.ncbi.nlm.nih.gov/pubmed/32161212
http://dx.doi.org/10.2183/pjab.96.007
_version_ 1783523557379145728
author TANAKA, Katsunori
VONG, Kenward
author_facet TANAKA, Katsunori
VONG, Kenward
author_sort TANAKA, Katsunori
collection PubMed
description In order to harness the functionality of metals, nature has evolved over billions of years to utilize metalloproteins as key components in numerous cellular processes. Despite this, transition metals such as ruthenium, palladium, iridium, and gold are largely absent from naturally occurring metalloproteins, likely due to their scarcity as precious metals. To mimic the evolutionary process of nature, the field of artificial metalloenzymes (ArMs) was born as a way to benefit from the unique chemoselectivity and orthogonality of transition metals in a biological setting. In its current state, numerous examples have successfully incorporated transition metals into a variety of protein scaffolds. Using these ArMs, many examples of new-to-nature reactions have been carried out, some of which have shown substantial biocompatibility. Given the rapid rate at which this field is growing, this review aims to highlight some important studies that have begun to take the next step within this field; namely the development of ArM-centered drug therapies or biotechnological tools.
format Online
Article
Text
id pubmed-7167364
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Japan Academy
record_format MEDLINE/PubMed
spelling pubmed-71673642020-04-24 Unlocking the therapeutic potential of artificial metalloenzymes TANAKA, Katsunori VONG, Kenward Proc Jpn Acad Ser B Phys Biol Sci Review In order to harness the functionality of metals, nature has evolved over billions of years to utilize metalloproteins as key components in numerous cellular processes. Despite this, transition metals such as ruthenium, palladium, iridium, and gold are largely absent from naturally occurring metalloproteins, likely due to their scarcity as precious metals. To mimic the evolutionary process of nature, the field of artificial metalloenzymes (ArMs) was born as a way to benefit from the unique chemoselectivity and orthogonality of transition metals in a biological setting. In its current state, numerous examples have successfully incorporated transition metals into a variety of protein scaffolds. Using these ArMs, many examples of new-to-nature reactions have been carried out, some of which have shown substantial biocompatibility. Given the rapid rate at which this field is growing, this review aims to highlight some important studies that have begun to take the next step within this field; namely the development of ArM-centered drug therapies or biotechnological tools. The Japan Academy 2020-03-11 /pmc/articles/PMC7167364/ /pubmed/32161212 http://dx.doi.org/10.2183/pjab.96.007 Text en © 2020 The Japan Academy This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
TANAKA, Katsunori
VONG, Kenward
Unlocking the therapeutic potential of artificial metalloenzymes
title Unlocking the therapeutic potential of artificial metalloenzymes
title_full Unlocking the therapeutic potential of artificial metalloenzymes
title_fullStr Unlocking the therapeutic potential of artificial metalloenzymes
title_full_unstemmed Unlocking the therapeutic potential of artificial metalloenzymes
title_short Unlocking the therapeutic potential of artificial metalloenzymes
title_sort unlocking the therapeutic potential of artificial metalloenzymes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167364/
https://www.ncbi.nlm.nih.gov/pubmed/32161212
http://dx.doi.org/10.2183/pjab.96.007
work_keys_str_mv AT tanakakatsunori unlockingthetherapeuticpotentialofartificialmetalloenzymes
AT vongkenward unlockingthetherapeuticpotentialofartificialmetalloenzymes