Mitochondrial disease disrupts hepatic allostasis and lowers the threshold for immune-mediated liver toxicity

OBJECTIVE: In individuals with mitochondrial disease, respiratory viral infection can result in metabolic decompensation with mitochondrial hepatopathy. Here, we used a mouse model of liver-specific Complex IV deficiency to study hepatic allostasis during respiratory viral infection. METHODS: Mice w...

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Detalles Bibliográficos
Autores principales: Jestin, Maxim, Kapnick, Senta M., Tarasenko, Tatyana N., Burke, Cassidy T., Zerfas, Patricia M., Diaz, Francisca, Vernon, Hilary, Singh, Larry N., Sokol, Ronald J., McGuire, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167504/
https://www.ncbi.nlm.nih.gov/pubmed/32283081
http://dx.doi.org/10.1016/j.molmet.2020.100981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167504/
https://www.ncbi.nlm.nih.gov/pubmed/32283081
http://dx.doi.org/10.1016/j.molmet.2020.100981

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