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Mitochondrial disease disrupts hepatic allostasis and lowers the threshold for immune-mediated liver toxicity

OBJECTIVE: In individuals with mitochondrial disease, respiratory viral infection can result in metabolic decompensation with mitochondrial hepatopathy. Here, we used a mouse model of liver-specific Complex IV deficiency to study hepatic allostasis during respiratory viral infection. METHODS: Mice w...

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Detalles Bibliográficos
Autores principales:	Jestin, Maxim, Kapnick, Senta M., Tarasenko, Tatyana N., Burke, Cassidy T., Zerfas, Patricia M., Diaz, Francisca, Vernon, Hilary, Singh, Larry N., Sokol, Ronald J., McGuire, Peter J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167504/ https://www.ncbi.nlm.nih.gov/pubmed/32283081 http://dx.doi.org/10.1016/j.molmet.2020.100981

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