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Different Immune Reconstitution between Cord Blood and Unrelated Bone Marrow Transplantation with Relation to Chronic Graft-versus-Host Disease

Background: Advances of allogeneic hematopoietic cell transplantation (allo-HCT) have brought long-term survival to the patients with hematologic malignancies. Chronic graft-versus-host disease (GVHD) is one of major problems for the long- term survivors after allo-HCT. Dysregulation of immune recon...

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Autores principales: Yoshida, Hitoshi, Koike, Midori, Tada, Yuma, Nakata, Keiichi, Hino, Akihisa, Fuji, Shigeo, Masaie, Hiroaki, Oka, Chihiro, Higeno, Akemi, Idota, Atsushi, Yamasaki, Tomoyuki, Ishikawa, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167606/
https://www.ncbi.nlm.nih.gov/pubmed/32337009
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author Yoshida, Hitoshi
Koike, Midori
Tada, Yuma
Nakata, Keiichi
Hino, Akihisa
Fuji, Shigeo
Masaie, Hiroaki
Oka, Chihiro
Higeno, Akemi
Idota, Atsushi
Yamasaki, Tomoyuki
Ishikawa, Jun
author_facet Yoshida, Hitoshi
Koike, Midori
Tada, Yuma
Nakata, Keiichi
Hino, Akihisa
Fuji, Shigeo
Masaie, Hiroaki
Oka, Chihiro
Higeno, Akemi
Idota, Atsushi
Yamasaki, Tomoyuki
Ishikawa, Jun
author_sort Yoshida, Hitoshi
collection PubMed
description Background: Advances of allogeneic hematopoietic cell transplantation (allo-HCT) have brought long-term survival to the patients with hematologic malignancies. Chronic graft-versus-host disease (GVHD) is one of major problems for the long- term survivors after allo-HCT. Dysregulation of immune reconstitution has been reported to be involved in the pathogenesis of chronic GVHD. Differences of immune reconstitution between cord blood transplantation (CBT) and unrelated bone marrow transplantation (UBMT) remain unclear in long-term survivors. We investigated immune reconstitution in patients surviving for more than 2 years after CBT (n=21) or UBMT (n=20) without relapse of underlying disease. Materials and Methods: Using flow cytometric analysis of peripheral blood, we investigated immune reconstitution of T cells, B cells, and NK cells between CBT and UBMT patients. We collected clinical data regarding allo-HCT and examined the relation of immune reconstitution to the development of chronic GVHD. Results: Between CBT and UBMT patients, we found significant differences in absolute cell number of CD8+ as well as CD19+ cell and CD4/CD8 ratio even more than 2 years after allo-HCT. Among UBMT patients, absolute cell number of naive CD4+ cell was significantly lower in patients with chronic GVHD. In addition, we found significant differences in absolute cell number of CD19+ cell, especially naive B cell between patients with and without chronic GVHD in both CBT and UBMT patients. Conclusion: These results suggest that differences of immune recovery between CBT and UBMT patients may exist even in patients surviving for more than 2 years and might be related to the development of chronic GVHD.
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spelling pubmed-71676062020-04-24 Different Immune Reconstitution between Cord Blood and Unrelated Bone Marrow Transplantation with Relation to Chronic Graft-versus-Host Disease Yoshida, Hitoshi Koike, Midori Tada, Yuma Nakata, Keiichi Hino, Akihisa Fuji, Shigeo Masaie, Hiroaki Oka, Chihiro Higeno, Akemi Idota, Atsushi Yamasaki, Tomoyuki Ishikawa, Jun Int J Hematol Oncol Stem Cell Res Original Article Background: Advances of allogeneic hematopoietic cell transplantation (allo-HCT) have brought long-term survival to the patients with hematologic malignancies. Chronic graft-versus-host disease (GVHD) is one of major problems for the long- term survivors after allo-HCT. Dysregulation of immune reconstitution has been reported to be involved in the pathogenesis of chronic GVHD. Differences of immune reconstitution between cord blood transplantation (CBT) and unrelated bone marrow transplantation (UBMT) remain unclear in long-term survivors. We investigated immune reconstitution in patients surviving for more than 2 years after CBT (n=21) or UBMT (n=20) without relapse of underlying disease. Materials and Methods: Using flow cytometric analysis of peripheral blood, we investigated immune reconstitution of T cells, B cells, and NK cells between CBT and UBMT patients. We collected clinical data regarding allo-HCT and examined the relation of immune reconstitution to the development of chronic GVHD. Results: Between CBT and UBMT patients, we found significant differences in absolute cell number of CD8+ as well as CD19+ cell and CD4/CD8 ratio even more than 2 years after allo-HCT. Among UBMT patients, absolute cell number of naive CD4+ cell was significantly lower in patients with chronic GVHD. In addition, we found significant differences in absolute cell number of CD19+ cell, especially naive B cell between patients with and without chronic GVHD in both CBT and UBMT patients. Conclusion: These results suggest that differences of immune recovery between CBT and UBMT patients may exist even in patients surviving for more than 2 years and might be related to the development of chronic GVHD. Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2020-01-01 /pmc/articles/PMC7167606/ /pubmed/32337009 Text en Copyright : © International Journal of Hematology-Oncology and Stem Cell Research & Tehran University of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yoshida, Hitoshi
Koike, Midori
Tada, Yuma
Nakata, Keiichi
Hino, Akihisa
Fuji, Shigeo
Masaie, Hiroaki
Oka, Chihiro
Higeno, Akemi
Idota, Atsushi
Yamasaki, Tomoyuki
Ishikawa, Jun
Different Immune Reconstitution between Cord Blood and Unrelated Bone Marrow Transplantation with Relation to Chronic Graft-versus-Host Disease
title Different Immune Reconstitution between Cord Blood and Unrelated Bone Marrow Transplantation with Relation to Chronic Graft-versus-Host Disease
title_full Different Immune Reconstitution between Cord Blood and Unrelated Bone Marrow Transplantation with Relation to Chronic Graft-versus-Host Disease
title_fullStr Different Immune Reconstitution between Cord Blood and Unrelated Bone Marrow Transplantation with Relation to Chronic Graft-versus-Host Disease
title_full_unstemmed Different Immune Reconstitution between Cord Blood and Unrelated Bone Marrow Transplantation with Relation to Chronic Graft-versus-Host Disease
title_short Different Immune Reconstitution between Cord Blood and Unrelated Bone Marrow Transplantation with Relation to Chronic Graft-versus-Host Disease
title_sort different immune reconstitution between cord blood and unrelated bone marrow transplantation with relation to chronic graft-versus-host disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167606/
https://www.ncbi.nlm.nih.gov/pubmed/32337009
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