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Association between Prurigo Nodularis and Etiologies of Peripheral Neuropathy: Suggesting a Role for Neural Dysregulation in Pathogenesis

Background: Prurigo nodularis (PN) is an intensely pruritic skin condition of considerable morbidity. However, the pathogenesis of PN and its association with underlying neuropathy is unclear. Objective: We sought to investigate the association between PN and etiologies of peripheral neuropathy. Met...

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Autores principales: Hughes, John-Douglas Matthew, Woo, Taylor E., Belzberg, Micah, Khanna, Raveena, Williams, Kyle A., Kwatra, Madan M., Hassan, Shahzeb, Kwatra, Shawn G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167799/
https://www.ncbi.nlm.nih.gov/pubmed/31936197
http://dx.doi.org/10.3390/medicines7010004
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author Hughes, John-Douglas Matthew
Woo, Taylor E.
Belzberg, Micah
Khanna, Raveena
Williams, Kyle A.
Kwatra, Madan M.
Hassan, Shahzeb
Kwatra, Shawn G.
author_facet Hughes, John-Douglas Matthew
Woo, Taylor E.
Belzberg, Micah
Khanna, Raveena
Williams, Kyle A.
Kwatra, Madan M.
Hassan, Shahzeb
Kwatra, Shawn G.
author_sort Hughes, John-Douglas Matthew
collection PubMed
description Background: Prurigo nodularis (PN) is an intensely pruritic skin condition of considerable morbidity. However, the pathogenesis of PN and its association with underlying neuropathy is unclear. Objective: We sought to investigate the association between PN and etiologies of peripheral neuropathy. Methods: A cross-sectional analysis of adult patients (≥18-year-old) with PN, AD, and Psoriasis at the Johns Hopkins Health System over a six-year period (January 2013–January 2019) was performed. The strength of association with etiologies of peripheral neuropathy were compared to a control cohort of individuals without PN, as well as those with AD or psoriasis. Results: A total of 1122 patients with PN were compared to 10,390 AD patients, 15,056 patients with psoriasis, and a control cohort of 4,949,017 individuals without PN, with respect to 25 comorbidities associated with peripheral neuropathies. Limitations: Comparisons between peripheral neuropathies and PN represent associations but are not causal relationships. Conclusion: Prurigo nodularis is strongly associated with peripheral neuropathies, suggesting a role for neural dysregulation in pathogenesis.
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spelling pubmed-71677992020-04-21 Association between Prurigo Nodularis and Etiologies of Peripheral Neuropathy: Suggesting a Role for Neural Dysregulation in Pathogenesis Hughes, John-Douglas Matthew Woo, Taylor E. Belzberg, Micah Khanna, Raveena Williams, Kyle A. Kwatra, Madan M. Hassan, Shahzeb Kwatra, Shawn G. Medicines (Basel) Article Background: Prurigo nodularis (PN) is an intensely pruritic skin condition of considerable morbidity. However, the pathogenesis of PN and its association with underlying neuropathy is unclear. Objective: We sought to investigate the association between PN and etiologies of peripheral neuropathy. Methods: A cross-sectional analysis of adult patients (≥18-year-old) with PN, AD, and Psoriasis at the Johns Hopkins Health System over a six-year period (January 2013–January 2019) was performed. The strength of association with etiologies of peripheral neuropathy were compared to a control cohort of individuals without PN, as well as those with AD or psoriasis. Results: A total of 1122 patients with PN were compared to 10,390 AD patients, 15,056 patients with psoriasis, and a control cohort of 4,949,017 individuals without PN, with respect to 25 comorbidities associated with peripheral neuropathies. Limitations: Comparisons between peripheral neuropathies and PN represent associations but are not causal relationships. Conclusion: Prurigo nodularis is strongly associated with peripheral neuropathies, suggesting a role for neural dysregulation in pathogenesis. MDPI 2020-01-08 /pmc/articles/PMC7167799/ /pubmed/31936197 http://dx.doi.org/10.3390/medicines7010004 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hughes, John-Douglas Matthew
Woo, Taylor E.
Belzberg, Micah
Khanna, Raveena
Williams, Kyle A.
Kwatra, Madan M.
Hassan, Shahzeb
Kwatra, Shawn G.
Association between Prurigo Nodularis and Etiologies of Peripheral Neuropathy: Suggesting a Role for Neural Dysregulation in Pathogenesis
title Association between Prurigo Nodularis and Etiologies of Peripheral Neuropathy: Suggesting a Role for Neural Dysregulation in Pathogenesis
title_full Association between Prurigo Nodularis and Etiologies of Peripheral Neuropathy: Suggesting a Role for Neural Dysregulation in Pathogenesis
title_fullStr Association between Prurigo Nodularis and Etiologies of Peripheral Neuropathy: Suggesting a Role for Neural Dysregulation in Pathogenesis
title_full_unstemmed Association between Prurigo Nodularis and Etiologies of Peripheral Neuropathy: Suggesting a Role for Neural Dysregulation in Pathogenesis
title_short Association between Prurigo Nodularis and Etiologies of Peripheral Neuropathy: Suggesting a Role for Neural Dysregulation in Pathogenesis
title_sort association between prurigo nodularis and etiologies of peripheral neuropathy: suggesting a role for neural dysregulation in pathogenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167799/
https://www.ncbi.nlm.nih.gov/pubmed/31936197
http://dx.doi.org/10.3390/medicines7010004
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