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Tear Break-Up Time and Seasonal Variation in Intraocular Pressure in a Japanese Population

Purpose: To evaluate seasonal variation in intraocular pressure (IOP) with and without short tear break-up time (SBUT, BUT ≤5 s) since dry eye and IOP are known to have seasonal variation. Methods: This study enrolled 176 patients who visited one of six eye clinics, in Japan, four times for IOP meas...

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Autores principales: Ayaki, Masahiko, Negishi, Kazuno, Yuki, Kenya, Kawashima, Motoko, Uchino, Miki, Tsubota, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167993/
https://www.ncbi.nlm.nih.gov/pubmed/32102457
http://dx.doi.org/10.3390/diagnostics10020124
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author Ayaki, Masahiko
Negishi, Kazuno
Yuki, Kenya
Kawashima, Motoko
Uchino, Miki
Tsubota, Kazuo
author_facet Ayaki, Masahiko
Negishi, Kazuno
Yuki, Kenya
Kawashima, Motoko
Uchino, Miki
Tsubota, Kazuo
author_sort Ayaki, Masahiko
collection PubMed
description Purpose: To evaluate seasonal variation in intraocular pressure (IOP) with and without short tear break-up time (SBUT, BUT ≤5 s) since dry eye and IOP are known to have seasonal variation. Methods: This study enrolled 176 patients who visited one of six eye clinics, in Japan, four times for IOP measurement, in every season. The mean patient age was 67.9 years, including 79 males. Participants were divided into four groups based on the presence of glaucoma and/or SBUT and we compared the seasonal variation in IOP (winter and summer) among the four groups. Results: The IOP (mmHg) in winter and summer, respectively, was 12.8 ± 3.7 and 12.8 ± 3.1 for non-glaucoma patients without SBUT (n = 47, p = 0.964), 14.8 ± 3.4 and 13.3 ± 3.4 for non-glaucoma patients with SBUT (n = 57, p < 0.001), 14.3 ± 3.2 and 14.1 ± 3.4 for glaucoma patients without SBUT (n = 36, p = 0.489), and 13.3 ± 3.0 and 11.6 ± 2.9 for glaucoma with SBUT (n = 36, p < 0.001). Seasonal variation was largest across the seasons in the glaucoma with the SBUT group, and the magnitude of seasonal variation correlated with BUT (β = 0.228, p = 0.003). Conclusions: Seasonal variation tended to be larger in patients with SBUT than those without SBUT.
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spelling pubmed-71679932020-04-21 Tear Break-Up Time and Seasonal Variation in Intraocular Pressure in a Japanese Population Ayaki, Masahiko Negishi, Kazuno Yuki, Kenya Kawashima, Motoko Uchino, Miki Tsubota, Kazuo Diagnostics (Basel) Article Purpose: To evaluate seasonal variation in intraocular pressure (IOP) with and without short tear break-up time (SBUT, BUT ≤5 s) since dry eye and IOP are known to have seasonal variation. Methods: This study enrolled 176 patients who visited one of six eye clinics, in Japan, four times for IOP measurement, in every season. The mean patient age was 67.9 years, including 79 males. Participants were divided into four groups based on the presence of glaucoma and/or SBUT and we compared the seasonal variation in IOP (winter and summer) among the four groups. Results: The IOP (mmHg) in winter and summer, respectively, was 12.8 ± 3.7 and 12.8 ± 3.1 for non-glaucoma patients without SBUT (n = 47, p = 0.964), 14.8 ± 3.4 and 13.3 ± 3.4 for non-glaucoma patients with SBUT (n = 57, p < 0.001), 14.3 ± 3.2 and 14.1 ± 3.4 for glaucoma patients without SBUT (n = 36, p = 0.489), and 13.3 ± 3.0 and 11.6 ± 2.9 for glaucoma with SBUT (n = 36, p < 0.001). Seasonal variation was largest across the seasons in the glaucoma with the SBUT group, and the magnitude of seasonal variation correlated with BUT (β = 0.228, p = 0.003). Conclusions: Seasonal variation tended to be larger in patients with SBUT than those without SBUT. MDPI 2020-02-24 /pmc/articles/PMC7167993/ /pubmed/32102457 http://dx.doi.org/10.3390/diagnostics10020124 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ayaki, Masahiko
Negishi, Kazuno
Yuki, Kenya
Kawashima, Motoko
Uchino, Miki
Tsubota, Kazuo
Tear Break-Up Time and Seasonal Variation in Intraocular Pressure in a Japanese Population
title Tear Break-Up Time and Seasonal Variation in Intraocular Pressure in a Japanese Population
title_full Tear Break-Up Time and Seasonal Variation in Intraocular Pressure in a Japanese Population
title_fullStr Tear Break-Up Time and Seasonal Variation in Intraocular Pressure in a Japanese Population
title_full_unstemmed Tear Break-Up Time and Seasonal Variation in Intraocular Pressure in a Japanese Population
title_short Tear Break-Up Time and Seasonal Variation in Intraocular Pressure in a Japanese Population
title_sort tear break-up time and seasonal variation in intraocular pressure in a japanese population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167993/
https://www.ncbi.nlm.nih.gov/pubmed/32102457
http://dx.doi.org/10.3390/diagnostics10020124
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