Multifunctional Polymeric Nanoplatforms for Brain Diseases Diagnosis, Therapy and Theranostics

The blood–brain barrier (BBB) acts as a barrier to prevent the central nervous system (CNS) from damage by substances that originate from the blood circulation. The BBB limits drug penetration into the brain and is one of the major clinical obstacles to the treatment of CNS diseases. Nanotechnology-...

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Autores principales: Shakeri, Shahryar, Ashrafizadeh, Milad, Zarrabi, Ali, Roghanian, Rasoul, Afshar, Elham Ghasemipour, Pardakhty, Abbas, Mohammadinejad, Reza, Kumar, Anuj, Thakur, Vijay Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168063/
https://www.ncbi.nlm.nih.gov/pubmed/31941057
http://dx.doi.org/10.3390/biomedicines8010013
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author Shakeri, Shahryar
Ashrafizadeh, Milad
Zarrabi, Ali
Roghanian, Rasoul
Afshar, Elham Ghasemipour
Pardakhty, Abbas
Mohammadinejad, Reza
Kumar, Anuj
Thakur, Vijay Kumar
author_facet Shakeri, Shahryar
Ashrafizadeh, Milad
Zarrabi, Ali
Roghanian, Rasoul
Afshar, Elham Ghasemipour
Pardakhty, Abbas
Mohammadinejad, Reza
Kumar, Anuj
Thakur, Vijay Kumar
author_sort Shakeri, Shahryar
collection PubMed
description The blood–brain barrier (BBB) acts as a barrier to prevent the central nervous system (CNS) from damage by substances that originate from the blood circulation. The BBB limits drug penetration into the brain and is one of the major clinical obstacles to the treatment of CNS diseases. Nanotechnology-based delivery systems have been tested for overcoming this barrier and releasing related drugs into the brain matrix. In this review, nanoparticles (NPs) from simple to developed delivery systems are discussed for the delivery of a drug to the brain. This review particularly focuses on polymeric nanomaterials that have been used for CNS treatment. Polymeric NPs such as polylactide (PLA), poly (D, L-lactide-co-glycolide) (PLGA), poly (ε-caprolactone) (PCL), poly (alkyl cyanoacrylate) (PACA), human serum albumin (HSA), gelatin, and chitosan are discussed in detail.
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spelling pubmed-71680632020-04-21 Multifunctional Polymeric Nanoplatforms for Brain Diseases Diagnosis, Therapy and Theranostics Shakeri, Shahryar Ashrafizadeh, Milad Zarrabi, Ali Roghanian, Rasoul Afshar, Elham Ghasemipour Pardakhty, Abbas Mohammadinejad, Reza Kumar, Anuj Thakur, Vijay Kumar Biomedicines Review The blood–brain barrier (BBB) acts as a barrier to prevent the central nervous system (CNS) from damage by substances that originate from the blood circulation. The BBB limits drug penetration into the brain and is one of the major clinical obstacles to the treatment of CNS diseases. Nanotechnology-based delivery systems have been tested for overcoming this barrier and releasing related drugs into the brain matrix. In this review, nanoparticles (NPs) from simple to developed delivery systems are discussed for the delivery of a drug to the brain. This review particularly focuses on polymeric nanomaterials that have been used for CNS treatment. Polymeric NPs such as polylactide (PLA), poly (D, L-lactide-co-glycolide) (PLGA), poly (ε-caprolactone) (PCL), poly (alkyl cyanoacrylate) (PACA), human serum albumin (HSA), gelatin, and chitosan are discussed in detail. MDPI 2020-01-13 /pmc/articles/PMC7168063/ /pubmed/31941057 http://dx.doi.org/10.3390/biomedicines8010013 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shakeri, Shahryar
Ashrafizadeh, Milad
Zarrabi, Ali
Roghanian, Rasoul
Afshar, Elham Ghasemipour
Pardakhty, Abbas
Mohammadinejad, Reza
Kumar, Anuj
Thakur, Vijay Kumar
Multifunctional Polymeric Nanoplatforms for Brain Diseases Diagnosis, Therapy and Theranostics
title Multifunctional Polymeric Nanoplatforms for Brain Diseases Diagnosis, Therapy and Theranostics
title_full Multifunctional Polymeric Nanoplatforms for Brain Diseases Diagnosis, Therapy and Theranostics
title_fullStr Multifunctional Polymeric Nanoplatforms for Brain Diseases Diagnosis, Therapy and Theranostics
title_full_unstemmed Multifunctional Polymeric Nanoplatforms for Brain Diseases Diagnosis, Therapy and Theranostics
title_short Multifunctional Polymeric Nanoplatforms for Brain Diseases Diagnosis, Therapy and Theranostics
title_sort multifunctional polymeric nanoplatforms for brain diseases diagnosis, therapy and theranostics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168063/
https://www.ncbi.nlm.nih.gov/pubmed/31941057
http://dx.doi.org/10.3390/biomedicines8010013
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