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In Vitro Antimicrobial Activity of Various Cefoperazone/Sulbactam Products
This study aims to assess the in vitro activity of different samples of cefoperazone/sulbactam (CFP/SUL) against multidrug-resistant organisms (MDROs). Clinical isolates of extended-spectrum β-lactamase (ESBL)-Escherichia coli, ESBL-Klebsiella pneumoniae, carbapenem-resistant Acinetobacter baumannii...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168170/ https://www.ncbi.nlm.nih.gov/pubmed/32059590 http://dx.doi.org/10.3390/antibiotics9020077 |
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author | Sheu, Ming-Jen Chen, Chi-Chung Lu, Ying-Chen Su, Bo-An Zhang, Chun-Cheng Wang, Shu-Shen Chuang, Yin-Ching Tang, Hung-Jen Lai, Chih-Cheng |
author_facet | Sheu, Ming-Jen Chen, Chi-Chung Lu, Ying-Chen Su, Bo-An Zhang, Chun-Cheng Wang, Shu-Shen Chuang, Yin-Ching Tang, Hung-Jen Lai, Chih-Cheng |
author_sort | Sheu, Ming-Jen |
collection | PubMed |
description | This study aims to assess the in vitro activity of different samples of cefoperazone/sulbactam (CFP/SUL) against multidrug-resistant organisms (MDROs). Clinical isolates of extended-spectrum β-lactamase (ESBL)-Escherichia coli, ESBL-Klebsiella pneumoniae, carbapenem-resistant Acinetobacter baumannii (CR-AB), and carbapenem-resistant Pseudomonas aeruginosa (CR-PA) were collected. The minimum inhibitory concentration (MIC) and time-killing methods were used to assess and compare the in vitro activities of different samples of cefoperazone/sulbactam (CFP/SUL) against these MDROs. For ESBL-E. coli, ESBL-K. pneumoniae, and CR-PA, product C had smaller variations than product A and B (p < 0.05). For CR-AB, product B had the largest variation compared to the other two products (p < 0.05). In the time-killing studies, significant differences among the products when used at 16/16 µg/mL were noted for ESBL-E. coli, ESBL-K. pneumoniae, and CR-AB isolates. In conclusion, this study demonstrated the significantly different activity of different products of CFP/SUL against MDROs. |
format | Online Article Text |
id | pubmed-7168170 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71681702020-04-21 In Vitro Antimicrobial Activity of Various Cefoperazone/Sulbactam Products Sheu, Ming-Jen Chen, Chi-Chung Lu, Ying-Chen Su, Bo-An Zhang, Chun-Cheng Wang, Shu-Shen Chuang, Yin-Ching Tang, Hung-Jen Lai, Chih-Cheng Antibiotics (Basel) Article This study aims to assess the in vitro activity of different samples of cefoperazone/sulbactam (CFP/SUL) against multidrug-resistant organisms (MDROs). Clinical isolates of extended-spectrum β-lactamase (ESBL)-Escherichia coli, ESBL-Klebsiella pneumoniae, carbapenem-resistant Acinetobacter baumannii (CR-AB), and carbapenem-resistant Pseudomonas aeruginosa (CR-PA) were collected. The minimum inhibitory concentration (MIC) and time-killing methods were used to assess and compare the in vitro activities of different samples of cefoperazone/sulbactam (CFP/SUL) against these MDROs. For ESBL-E. coli, ESBL-K. pneumoniae, and CR-PA, product C had smaller variations than product A and B (p < 0.05). For CR-AB, product B had the largest variation compared to the other two products (p < 0.05). In the time-killing studies, significant differences among the products when used at 16/16 µg/mL were noted for ESBL-E. coli, ESBL-K. pneumoniae, and CR-AB isolates. In conclusion, this study demonstrated the significantly different activity of different products of CFP/SUL against MDROs. MDPI 2020-02-12 /pmc/articles/PMC7168170/ /pubmed/32059590 http://dx.doi.org/10.3390/antibiotics9020077 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sheu, Ming-Jen Chen, Chi-Chung Lu, Ying-Chen Su, Bo-An Zhang, Chun-Cheng Wang, Shu-Shen Chuang, Yin-Ching Tang, Hung-Jen Lai, Chih-Cheng In Vitro Antimicrobial Activity of Various Cefoperazone/Sulbactam Products |
title | In Vitro Antimicrobial Activity of Various Cefoperazone/Sulbactam Products |
title_full | In Vitro Antimicrobial Activity of Various Cefoperazone/Sulbactam Products |
title_fullStr | In Vitro Antimicrobial Activity of Various Cefoperazone/Sulbactam Products |
title_full_unstemmed | In Vitro Antimicrobial Activity of Various Cefoperazone/Sulbactam Products |
title_short | In Vitro Antimicrobial Activity of Various Cefoperazone/Sulbactam Products |
title_sort | in vitro antimicrobial activity of various cefoperazone/sulbactam products |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168170/ https://www.ncbi.nlm.nih.gov/pubmed/32059590 http://dx.doi.org/10.3390/antibiotics9020077 |
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