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Cerebral Microbleeds in a Stroke Prevention Clinic
The objective of this study was to assess the effectiveness of a stroke clinic in stroke prevention and progression of cerebral microbleeds (CMB). We conducted a retrospective observational study of patients who visited a stroke clinic between January 2011 and March 2017. Susceptibility-weighted ima...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168200/ https://www.ncbi.nlm.nih.gov/pubmed/31905954 http://dx.doi.org/10.3390/diagnostics10010018 |
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author | Cho, A-Hyun Wadi, Lara Chow, Daniel Chang, Peter Floriolli, David Shah, Krunal Paganini-Hill, Annlia Fisher, Mark |
author_facet | Cho, A-Hyun Wadi, Lara Chow, Daniel Chang, Peter Floriolli, David Shah, Krunal Paganini-Hill, Annlia Fisher, Mark |
author_sort | Cho, A-Hyun |
collection | PubMed |
description | The objective of this study was to assess the effectiveness of a stroke clinic in stroke prevention and progression of cerebral microbleeds (CMB). We conducted a retrospective observational study of patients who visited a stroke clinic between January 2011 and March 2017. Susceptibility-weighted imaging (SWI) MRI studies were obtained at baseline and follow-up visits to identify new infarctions and CMB progression. Patients with CMB who also underwent brain computed tomography (CT) imaging were identified and their cerebral arterial calcification was quantified to evaluate the relationship between the extent of intracranial calcification and CMB burden. A total of 64 stroke patients (mean age 73.1 ± 11.0, 47% males) had CMB on baseline and follow-up MRI studies. During a mean follow-up period of 22.6 months, four strokes occurred (4/64, 6%; 3 ischemic, 1 hemorrhagic), producing mild neurological deficit. Progression of CMB was observed in 54% of patients with two MRIs and was significantly associated with length of follow-up. Subjects with intracranial calcification score > 300 cm(3) had higher CMB count than those with scores <300 cm(3) at both baseline (12.6 ± 11.7 vs. 4.9 ± 2.2, p = 0.02) and follow-up (14.1 ± 11.8 vs. 5.6 ± 2.4, p = 0.03) MRI evaluations. Patients with CMB had a relatively benign overall clinical course. The association between CMB burden and intracranial calcification warrants further study. |
format | Online Article Text |
id | pubmed-7168200 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71682002020-04-21 Cerebral Microbleeds in a Stroke Prevention Clinic Cho, A-Hyun Wadi, Lara Chow, Daniel Chang, Peter Floriolli, David Shah, Krunal Paganini-Hill, Annlia Fisher, Mark Diagnostics (Basel) Article The objective of this study was to assess the effectiveness of a stroke clinic in stroke prevention and progression of cerebral microbleeds (CMB). We conducted a retrospective observational study of patients who visited a stroke clinic between January 2011 and March 2017. Susceptibility-weighted imaging (SWI) MRI studies were obtained at baseline and follow-up visits to identify new infarctions and CMB progression. Patients with CMB who also underwent brain computed tomography (CT) imaging were identified and their cerebral arterial calcification was quantified to evaluate the relationship between the extent of intracranial calcification and CMB burden. A total of 64 stroke patients (mean age 73.1 ± 11.0, 47% males) had CMB on baseline and follow-up MRI studies. During a mean follow-up period of 22.6 months, four strokes occurred (4/64, 6%; 3 ischemic, 1 hemorrhagic), producing mild neurological deficit. Progression of CMB was observed in 54% of patients with two MRIs and was significantly associated with length of follow-up. Subjects with intracranial calcification score > 300 cm(3) had higher CMB count than those with scores <300 cm(3) at both baseline (12.6 ± 11.7 vs. 4.9 ± 2.2, p = 0.02) and follow-up (14.1 ± 11.8 vs. 5.6 ± 2.4, p = 0.03) MRI evaluations. Patients with CMB had a relatively benign overall clinical course. The association between CMB burden and intracranial calcification warrants further study. MDPI 2019-12-30 /pmc/articles/PMC7168200/ /pubmed/31905954 http://dx.doi.org/10.3390/diagnostics10010018 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cho, A-Hyun Wadi, Lara Chow, Daniel Chang, Peter Floriolli, David Shah, Krunal Paganini-Hill, Annlia Fisher, Mark Cerebral Microbleeds in a Stroke Prevention Clinic |
title | Cerebral Microbleeds in a Stroke Prevention Clinic |
title_full | Cerebral Microbleeds in a Stroke Prevention Clinic |
title_fullStr | Cerebral Microbleeds in a Stroke Prevention Clinic |
title_full_unstemmed | Cerebral Microbleeds in a Stroke Prevention Clinic |
title_short | Cerebral Microbleeds in a Stroke Prevention Clinic |
title_sort | cerebral microbleeds in a stroke prevention clinic |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168200/ https://www.ncbi.nlm.nih.gov/pubmed/31905954 http://dx.doi.org/10.3390/diagnostics10010018 |
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