Cargando…

HPV Oncoproteins and the Ubiquitin Proteasome System: A Signature of Malignancy?

Human papillomavirus (HPV) E6 and E7 oncoproteins are critical for development and maintenance of the malignant phenotype in HPV-induced cancers. These two viral oncoproteins interfere with a plethora of cellular pathways, including the regulation of cell cycle and the control of apoptosis, which ar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Đukić, Anamaria, Lulić, Lucija, Thomas, Miranda, Skelin, Josipa, Bennett Saidu, Nathaniel Edward, Grce, Magdalena, Banks, Lawrence, Tomaić, Vjekoslav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168213/ https://www.ncbi.nlm.nih.gov/pubmed/32085533 http://dx.doi.org/10.3390/pathogens9020133

Ejemplares similares

Human Papillomaviruses-Associated Cancers: An Update of Current Knowledge
por: Pešut, Ena, et al.
Publicado: (2021)

Comparative Analysis of Alpha and Beta HPV E6 Oncoproteins: Insights into Functional Distinctions and Divergent Mechanisms of Pathogenesis
por: Skelin, Josipa, et al.
Publicado: (2023)

HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers
por: Lulić, Lucija, et al.
Publicado: (2023)

Do or Die: HPV E5, E6 and E7 in Cell Death Evasion
por: Skelin, Josipa, et al.
Publicado: (2022)

Human DLG1 and SCRIB Are Distinctly Regulated Independently of HPV-16 during the Progression of Oropharyngeal Squamous Cell Carcinomas: A Preliminary Analysis
por: Lulić, Lucija, et al.
Publicado: (2021)

Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites
por: Tomaić, Vjekoslav
Publicado: (2016)

Angelman syndrome-associated ubiquitin ligase UBE3A/E6AP mutants interfere with the proteolytic activity of the proteasome
por: Tomaić, V, et al.
Publicado: (2015)

The high-risk HPV E6 target scribble (hScrib) is required for HPV E6 expression in cervical tumour-derived cell lines
por: Kranjec, Christian, et al.
Publicado: (2016)

Docosahexaenoic acid induces the degradation of HPV E6/E7 oncoproteins by activating the ubiquitin–proteasome system
por: Jing, K, et al.
Publicado: (2014)

Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways
por: Ganti, Ketaki, et al.
Publicado: (2016)

Ubiquitination-dependent, proteasomal degradation of the retroviral oncoprotein Tax by niclosamide, an anti-helminthic molecule
por: Xiang, Di, et al.
Publicado: (2014)

ATP synthase modulation leads to an increase of spare respiratory capacity in HPV associated cancers
por: Kirschberg, Matthias, et al.
Publicado: (2020)

Manipulation of Epithelial Differentiation by HPV Oncoproteins
por: White, Elizabeth A.
Publicado: (2019)

Ubiquitin Proteasome Gene Signatures in Ependymoma Molecular Subtypes
por: Vriend, Jerry, et al.
Publicado: (2022)

The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis
por: Basukala, Om, et al.
Publicado: (2021)

Inhibition of kinase IKKβ suppresses cellular abnormalities induced by the human papillomavirus oncoprotein HPV 18E6
por: Padash Barmchi, Mojgan, et al.
Publicado: (2021)

Ubiquitination of the HPV Oncoprotein E6 Is Critical for E6/E6AP-Mediated p53 Degradation
por: Li, Siying, et al.
Publicado: (2019)

Ehrlichia chaffeensis TRP120-mediated ubiquitination and proteasomal degradation of tumor suppressor FBW7 increases oncoprotein stability and promotes infection
por: Wang, Jennifer Y., et al.
Publicado: (2020)

Caries prevalence among schoolchildren in Zagreb, Croatia
por: Dukić, Walter, et al.
Publicado: (2011)

Novel Affibody Molecules Targeting the HPV16 E6 Oncoprotein Inhibited the Proliferation of Cervical Cancer Cells
por: Zhu, Jinshun, et al.
Publicado: (2021)

New Approaches for the Treatment of Chronic Graft-Versus-Host Disease: Current Status and Future Directions
por: Saidu, Nathaniel Edward Bennett, et al.
Publicado: (2020)

Inactivation of beta1 integrin induces proteasomal degradation of Myc oncoproteins
por: Sasada, Manabu, et al.
Publicado: (2019)

Fungal Secondary Metabolites as Inhibitors of the Ubiquitin–Proteasome System
por: Staszczak, Magdalena
Publicado: (2021)

A Ubiquitin-Proteasome Gene Signature for Predicting Prognosis in Patients With Lung Adenocarcinoma
por: Tang, Yunliang, et al.
Publicado: (2022)

Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway
por: Gain, Chandrima, et al.
Publicado: (2020)

The ubiquitin-proteasome pathway in cancer.
por: Spataro, V., et al.
Publicado: (1998)

The ubiquitin proteasome system in neuropathology
por: Lehman, Norman L.
Publicado: (2009)

The recognition of ubiquitinated proteins by the proteasome
por: Grice, Guinevere L., et al.
Publicado: (2016)

Ubiquitin-proteasome system-based signature to predict the prognosis and drug sensitivity of hepatocellular carcinoma
por: Zhang, Jianxiang, et al.
Publicado: (2023)

The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy
por: Ganti, Ketaki, et al.
Publicado: (2015)

Expression of the HPV18/E6 oncoprotein induces DNA damage
por: Gutierrez, Elva I. Cortes, et al.
Publicado: (2017)

hrHPV E5 oncoprotein: immune evasion and related immunotherapies
por: de Freitas, Antonio Carlos, et al.
Publicado: (2017)

The Ubiquitin Conjugating Enzyme: An Important Ubiquitin Transfer Platform in Ubiquitin-Proteasome System
por: Liu, Weigang, et al.
Publicado: (2020)

Poxvirus Exploitation of the Ubiquitin-Proteasome System
por: Barry, Michele, et al.
Publicado: (2010)

The Ubiquitin-Proteasome Pathway in Huntington's Disease
por: Mitra, Siddhartha, et al.
Publicado: (2008)

Enzymatic Blockade of the Ubiquitin-Proteasome Pathway
por: Ernst, Robert, et al.
Publicado: (2011)

The ubiquitin-proteasome system in Alzheimer's disease
por: Oddo, Salvatore
Publicado: (2008)

Autoregulation of the 26S proteasome by in situ ubiquitination
por: Jacobson, Andrew D., et al.
Publicado: (2014)

Ubiquitin Proteasome System in Stress and Disease
por: Karpov, Dmitry, et al.
Publicado: (2012)

Intracellular Dynamics of the Ubiquitin-Proteasome-System
por: Chowdhury, Maisha, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_2otqcsruj502kjdj1pq6a17ld7