Cargando…
Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients
A disintegrin and metalloproteinase with thrombospondin motif 14 (ADAMTS14) is a member of the zinc-dependent protease family that is implicated in the occurrence and progression of tumors. Oral cancer (OC) is a common cancer worldwide, but it is particularly prevalent in Taiwan. However, whether th...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168220/ https://www.ncbi.nlm.nih.gov/pubmed/32102222 http://dx.doi.org/10.3390/diagnostics10020122 |
_version_ | 1783523637834285056 |
---|---|
author | Lin, Yueh-Min Lin, Chiao-Wen Lu, Jeng-Wei Yeh, Kun-Tu Lin, Shu-Hui Yang, Shun-Fa |
author_facet | Lin, Yueh-Min Lin, Chiao-Wen Lu, Jeng-Wei Yeh, Kun-Tu Lin, Shu-Hui Yang, Shun-Fa |
author_sort | Lin, Yueh-Min |
collection | PubMed |
description | A disintegrin and metalloproteinase with thrombospondin motif 14 (ADAMTS14) is a member of the zinc-dependent protease family that is implicated in the occurrence and progression of tumors. Oral cancer (OC) is a common cancer worldwide, but it is particularly prevalent in Taiwan. However, whether the expression of ADAMTS14 is correlated with the carcinogenesis and progression of oral squamous cell carcinoma (OSCC) has not yet been investigated. In this study, we used immunohistochemistry (IHC) to examine 250 OSCC specimens in order to identify correlations between the cytoplasmic expression of ADAMTS14 and (1) clinicopathological features of OSCC as well as (2) clinical outcomes of OSCC. Our results indicate that cytoplasmic expression of ADAMTS14 was lower in OSCC tissues than in normal tissues. In analyzing correlations between ADAMTS14 expression and clinicopathological features, we found that negative cytoplasmic expression of ADAMTS14 was significantly associated with higher frequencies of lymph node metastasis and more advanced AJCC stages (III/IV). Kaplan–Meier survival analysis revealed that negative cytoplasmic expression of ADAMTS14 was also associated with significantly worse OSCC survival. Univariate and multivariate analyses confirmed that cytoplasmic expression of ADAMTS14 was associated with lymph node metastasis, tumor stage, and tumor grade and also indicated that cytoplasmic ADAMTS14 expression may be an independent prognostic factor for OSCC. This is the first study to report that the cytoplasmic expression level of ADAMTS14 is associated with OSCC prognosis and tumor progression. Our data indicate that ADAMTS14 can serve as a prognostic marker and a potential therapeutic target for OSCC. |
format | Online Article Text |
id | pubmed-7168220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71682202020-04-22 Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients Lin, Yueh-Min Lin, Chiao-Wen Lu, Jeng-Wei Yeh, Kun-Tu Lin, Shu-Hui Yang, Shun-Fa Diagnostics (Basel) Article A disintegrin and metalloproteinase with thrombospondin motif 14 (ADAMTS14) is a member of the zinc-dependent protease family that is implicated in the occurrence and progression of tumors. Oral cancer (OC) is a common cancer worldwide, but it is particularly prevalent in Taiwan. However, whether the expression of ADAMTS14 is correlated with the carcinogenesis and progression of oral squamous cell carcinoma (OSCC) has not yet been investigated. In this study, we used immunohistochemistry (IHC) to examine 250 OSCC specimens in order to identify correlations between the cytoplasmic expression of ADAMTS14 and (1) clinicopathological features of OSCC as well as (2) clinical outcomes of OSCC. Our results indicate that cytoplasmic expression of ADAMTS14 was lower in OSCC tissues than in normal tissues. In analyzing correlations between ADAMTS14 expression and clinicopathological features, we found that negative cytoplasmic expression of ADAMTS14 was significantly associated with higher frequencies of lymph node metastasis and more advanced AJCC stages (III/IV). Kaplan–Meier survival analysis revealed that negative cytoplasmic expression of ADAMTS14 was also associated with significantly worse OSCC survival. Univariate and multivariate analyses confirmed that cytoplasmic expression of ADAMTS14 was associated with lymph node metastasis, tumor stage, and tumor grade and also indicated that cytoplasmic ADAMTS14 expression may be an independent prognostic factor for OSCC. This is the first study to report that the cytoplasmic expression level of ADAMTS14 is associated with OSCC prognosis and tumor progression. Our data indicate that ADAMTS14 can serve as a prognostic marker and a potential therapeutic target for OSCC. MDPI 2020-02-23 /pmc/articles/PMC7168220/ /pubmed/32102222 http://dx.doi.org/10.3390/diagnostics10020122 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lin, Yueh-Min Lin, Chiao-Wen Lu, Jeng-Wei Yeh, Kun-Tu Lin, Shu-Hui Yang, Shun-Fa Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients |
title | Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients |
title_full | Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients |
title_fullStr | Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients |
title_full_unstemmed | Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients |
title_short | Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients |
title_sort | decreased cytoplasmic expression of adamts14 is correlated with reduced survival rates in oral squamous cell carcinoma patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168220/ https://www.ncbi.nlm.nih.gov/pubmed/32102222 http://dx.doi.org/10.3390/diagnostics10020122 |
work_keys_str_mv | AT linyuehmin decreasedcytoplasmicexpressionofadamts14iscorrelatedwithreducedsurvivalratesinoralsquamouscellcarcinomapatients AT linchiaowen decreasedcytoplasmicexpressionofadamts14iscorrelatedwithreducedsurvivalratesinoralsquamouscellcarcinomapatients AT lujengwei decreasedcytoplasmicexpressionofadamts14iscorrelatedwithreducedsurvivalratesinoralsquamouscellcarcinomapatients AT yehkuntu decreasedcytoplasmicexpressionofadamts14iscorrelatedwithreducedsurvivalratesinoralsquamouscellcarcinomapatients AT linshuhui decreasedcytoplasmicexpressionofadamts14iscorrelatedwithreducedsurvivalratesinoralsquamouscellcarcinomapatients AT yangshunfa decreasedcytoplasmicexpressionofadamts14iscorrelatedwithreducedsurvivalratesinoralsquamouscellcarcinomapatients |