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Modified Aminoglycosides Bind Nucleic Acids in High-Molecular-Weight Complexes

Aminoglycosides represent a large group of antibiotics well known for their ability to target the bacterial ribosome. In studying 6”-substituted variants of the aminoglycoside tobramycin, we serendipitously found that compounds with C(12) or C(14) linear alkyl substituents potently inhibit reverse t...

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Detalles Bibliográficos
Autores principales:	Ying, Lanqing, Zhu, Hongkun, Fosso, Marina Y., Garneau-Tsodikova, Sylvie, Fredrick, Kurt
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168264/ https://www.ncbi.nlm.nih.gov/pubmed/32098020 http://dx.doi.org/10.3390/antibiotics9020093

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