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Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice

Ultraviolet (UV) light induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Astaxanthin (AST), a ketocarotenoid isolated from Haematococcus pluvialis, has been extensively studied owing to its possible effects on skin health as well as UV protection. I...

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Autores principales: Li, Xing, Matsumoto, Tomohiro, Takuwa, Miho, Saeed Ebrahim Shaiku Ali, Mahmood, Hirabashi, Takumi, Kondo, Hiroyo, Fujino, Hidemi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168265/
https://www.ncbi.nlm.nih.gov/pubmed/31973028
http://dx.doi.org/10.3390/biomedicines8020018
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author Li, Xing
Matsumoto, Tomohiro
Takuwa, Miho
Saeed Ebrahim Shaiku Ali, Mahmood
Hirabashi, Takumi
Kondo, Hiroyo
Fujino, Hidemi
author_facet Li, Xing
Matsumoto, Tomohiro
Takuwa, Miho
Saeed Ebrahim Shaiku Ali, Mahmood
Hirabashi, Takumi
Kondo, Hiroyo
Fujino, Hidemi
author_sort Li, Xing
collection PubMed
description Ultraviolet (UV) light induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Astaxanthin (AST), a ketocarotenoid isolated from Haematococcus pluvialis, has been extensively studied owing to its possible effects on skin health as well as UV protection. In addition, AST attenuates the increased generation of reactive oxygen species (ROS) and capillary regression of the skeletal muscle. In this study, we investigated whether AST could protect against UV-induced photoaging and reduce capillary regression in the skin of HR-1 hairless mice. UV light induces wrinkle formation, epidermal thickening, and capillary regression in the dermis of HR-1 hairless mice. The administration of AST reduced the UV-induced wrinkle formation and skin thickening, and increased collagen fibers in the skin. AST supplementation also inhibited the generation of ROS, decreased wrinkle formation, reduced epidermal thickening, and increased the density of capillaries in the skin. We also found an inverse correlation between wrinkle formation and the density of capillaries. An association between photoaging and capillary regression in the skin was also observed. These results suggest that AST can protect against photoaging caused by UV irradiation and the inhibitory effects of AST on photoaging may be associated with the reduction of capillary regression in the skin.
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spelling pubmed-71682652020-04-22 Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice Li, Xing Matsumoto, Tomohiro Takuwa, Miho Saeed Ebrahim Shaiku Ali, Mahmood Hirabashi, Takumi Kondo, Hiroyo Fujino, Hidemi Biomedicines Article Ultraviolet (UV) light induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Astaxanthin (AST), a ketocarotenoid isolated from Haematococcus pluvialis, has been extensively studied owing to its possible effects on skin health as well as UV protection. In addition, AST attenuates the increased generation of reactive oxygen species (ROS) and capillary regression of the skeletal muscle. In this study, we investigated whether AST could protect against UV-induced photoaging and reduce capillary regression in the skin of HR-1 hairless mice. UV light induces wrinkle formation, epidermal thickening, and capillary regression in the dermis of HR-1 hairless mice. The administration of AST reduced the UV-induced wrinkle formation and skin thickening, and increased collagen fibers in the skin. AST supplementation also inhibited the generation of ROS, decreased wrinkle formation, reduced epidermal thickening, and increased the density of capillaries in the skin. We also found an inverse correlation between wrinkle formation and the density of capillaries. An association between photoaging and capillary regression in the skin was also observed. These results suggest that AST can protect against photoaging caused by UV irradiation and the inhibitory effects of AST on photoaging may be associated with the reduction of capillary regression in the skin. MDPI 2020-01-21 /pmc/articles/PMC7168265/ /pubmed/31973028 http://dx.doi.org/10.3390/biomedicines8020018 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Xing
Matsumoto, Tomohiro
Takuwa, Miho
Saeed Ebrahim Shaiku Ali, Mahmood
Hirabashi, Takumi
Kondo, Hiroyo
Fujino, Hidemi
Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice
title Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice
title_full Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice
title_fullStr Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice
title_full_unstemmed Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice
title_short Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice
title_sort protective effects of astaxanthin supplementation against ultraviolet-induced photoaging in hairless mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168265/
https://www.ncbi.nlm.nih.gov/pubmed/31973028
http://dx.doi.org/10.3390/biomedicines8020018
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