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Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice
Ultraviolet (UV) light induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Astaxanthin (AST), a ketocarotenoid isolated from Haematococcus pluvialis, has been extensively studied owing to its possible effects on skin health as well as UV protection. I...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168265/ https://www.ncbi.nlm.nih.gov/pubmed/31973028 http://dx.doi.org/10.3390/biomedicines8020018 |
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author | Li, Xing Matsumoto, Tomohiro Takuwa, Miho Saeed Ebrahim Shaiku Ali, Mahmood Hirabashi, Takumi Kondo, Hiroyo Fujino, Hidemi |
author_facet | Li, Xing Matsumoto, Tomohiro Takuwa, Miho Saeed Ebrahim Shaiku Ali, Mahmood Hirabashi, Takumi Kondo, Hiroyo Fujino, Hidemi |
author_sort | Li, Xing |
collection | PubMed |
description | Ultraviolet (UV) light induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Astaxanthin (AST), a ketocarotenoid isolated from Haematococcus pluvialis, has been extensively studied owing to its possible effects on skin health as well as UV protection. In addition, AST attenuates the increased generation of reactive oxygen species (ROS) and capillary regression of the skeletal muscle. In this study, we investigated whether AST could protect against UV-induced photoaging and reduce capillary regression in the skin of HR-1 hairless mice. UV light induces wrinkle formation, epidermal thickening, and capillary regression in the dermis of HR-1 hairless mice. The administration of AST reduced the UV-induced wrinkle formation and skin thickening, and increased collagen fibers in the skin. AST supplementation also inhibited the generation of ROS, decreased wrinkle formation, reduced epidermal thickening, and increased the density of capillaries in the skin. We also found an inverse correlation between wrinkle formation and the density of capillaries. An association between photoaging and capillary regression in the skin was also observed. These results suggest that AST can protect against photoaging caused by UV irradiation and the inhibitory effects of AST on photoaging may be associated with the reduction of capillary regression in the skin. |
format | Online Article Text |
id | pubmed-7168265 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71682652020-04-22 Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice Li, Xing Matsumoto, Tomohiro Takuwa, Miho Saeed Ebrahim Shaiku Ali, Mahmood Hirabashi, Takumi Kondo, Hiroyo Fujino, Hidemi Biomedicines Article Ultraviolet (UV) light induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Astaxanthin (AST), a ketocarotenoid isolated from Haematococcus pluvialis, has been extensively studied owing to its possible effects on skin health as well as UV protection. In addition, AST attenuates the increased generation of reactive oxygen species (ROS) and capillary regression of the skeletal muscle. In this study, we investigated whether AST could protect against UV-induced photoaging and reduce capillary regression in the skin of HR-1 hairless mice. UV light induces wrinkle formation, epidermal thickening, and capillary regression in the dermis of HR-1 hairless mice. The administration of AST reduced the UV-induced wrinkle formation and skin thickening, and increased collagen fibers in the skin. AST supplementation also inhibited the generation of ROS, decreased wrinkle formation, reduced epidermal thickening, and increased the density of capillaries in the skin. We also found an inverse correlation between wrinkle formation and the density of capillaries. An association between photoaging and capillary regression in the skin was also observed. These results suggest that AST can protect against photoaging caused by UV irradiation and the inhibitory effects of AST on photoaging may be associated with the reduction of capillary regression in the skin. MDPI 2020-01-21 /pmc/articles/PMC7168265/ /pubmed/31973028 http://dx.doi.org/10.3390/biomedicines8020018 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li, Xing Matsumoto, Tomohiro Takuwa, Miho Saeed Ebrahim Shaiku Ali, Mahmood Hirabashi, Takumi Kondo, Hiroyo Fujino, Hidemi Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice |
title | Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice |
title_full | Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice |
title_fullStr | Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice |
title_full_unstemmed | Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice |
title_short | Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice |
title_sort | protective effects of astaxanthin supplementation against ultraviolet-induced photoaging in hairless mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168265/ https://www.ncbi.nlm.nih.gov/pubmed/31973028 http://dx.doi.org/10.3390/biomedicines8020018 |
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