Gastric Cancer Stem Cells: Current Insights into the Immune Microenvironment and Therapeutic Targets

Gastric cancer (GC) is a leading cause of cancer-related death worldwide. Cancer stem cells (CSCs) are known to be involved in chemotherapy resistance and the development of metastases. Although CSCs harbor self-renewal and tumorigenic abilities, the immune microenvironment surrounding CSCs provides...

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Autores principales: Fu, Lingfeng, Bu, Luke, Yasuda, Tadahito, Koiwa, Mayu, Akiyama, Takahiko, Uchihara, Tomoyuki, Baba, Hideo, Ishimoto, Takatsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168269/
https://www.ncbi.nlm.nih.gov/pubmed/31935894
http://dx.doi.org/10.3390/biomedicines8010007
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author Fu, Lingfeng
Bu, Luke
Yasuda, Tadahito
Koiwa, Mayu
Akiyama, Takahiko
Uchihara, Tomoyuki
Baba, Hideo
Ishimoto, Takatsugu
author_facet Fu, Lingfeng
Bu, Luke
Yasuda, Tadahito
Koiwa, Mayu
Akiyama, Takahiko
Uchihara, Tomoyuki
Baba, Hideo
Ishimoto, Takatsugu
author_sort Fu, Lingfeng
collection PubMed
description Gastric cancer (GC) is a leading cause of cancer-related death worldwide. Cancer stem cells (CSCs) are known to be involved in chemotherapy resistance and the development of metastases. Although CSCs harbor self-renewal and tumorigenic abilities, the immune microenvironment surrounding CSCs provides various factors and supports the maintenance of CSC properties. The current review summarizes the accumulating findings regarding the relationship between the immune microenvironment and gastric CSCs (GCSCs), which will support the possibility of developing novel therapeutic strategies for targeting GCSCs.
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spelling pubmed-71682692020-04-22 Gastric Cancer Stem Cells: Current Insights into the Immune Microenvironment and Therapeutic Targets Fu, Lingfeng Bu, Luke Yasuda, Tadahito Koiwa, Mayu Akiyama, Takahiko Uchihara, Tomoyuki Baba, Hideo Ishimoto, Takatsugu Biomedicines Review Gastric cancer (GC) is a leading cause of cancer-related death worldwide. Cancer stem cells (CSCs) are known to be involved in chemotherapy resistance and the development of metastases. Although CSCs harbor self-renewal and tumorigenic abilities, the immune microenvironment surrounding CSCs provides various factors and supports the maintenance of CSC properties. The current review summarizes the accumulating findings regarding the relationship between the immune microenvironment and gastric CSCs (GCSCs), which will support the possibility of developing novel therapeutic strategies for targeting GCSCs. MDPI 2020-01-06 /pmc/articles/PMC7168269/ /pubmed/31935894 http://dx.doi.org/10.3390/biomedicines8010007 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fu, Lingfeng
Bu, Luke
Yasuda, Tadahito
Koiwa, Mayu
Akiyama, Takahiko
Uchihara, Tomoyuki
Baba, Hideo
Ishimoto, Takatsugu
Gastric Cancer Stem Cells: Current Insights into the Immune Microenvironment and Therapeutic Targets
title Gastric Cancer Stem Cells: Current Insights into the Immune Microenvironment and Therapeutic Targets
title_full Gastric Cancer Stem Cells: Current Insights into the Immune Microenvironment and Therapeutic Targets
title_fullStr Gastric Cancer Stem Cells: Current Insights into the Immune Microenvironment and Therapeutic Targets
title_full_unstemmed Gastric Cancer Stem Cells: Current Insights into the Immune Microenvironment and Therapeutic Targets
title_short Gastric Cancer Stem Cells: Current Insights into the Immune Microenvironment and Therapeutic Targets
title_sort gastric cancer stem cells: current insights into the immune microenvironment and therapeutic targets
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168269/
https://www.ncbi.nlm.nih.gov/pubmed/31935894
http://dx.doi.org/10.3390/biomedicines8010007
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