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Admission Serum Potassium Levels in Hospitalized Patients and One-Year Mortality

Background: The aim of this study was to assess the relationship between admission serum potassium and one-year mortality in all adult hospitalized patients. Methods: All adult hospitalized patients who had an admission serum potassium level between the years 2011 and 2013 at a tertiary referral hos...

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Autores principales: Thongprayoon, Charat, Cheungpasitporn, Wisit, Hansrivijit, Panupong, Mao, Michael A., Medaura, Juan, Bathini, Tarun, Chewcharat, Api, Erickson, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168271/
https://www.ncbi.nlm.nih.gov/pubmed/31905856
http://dx.doi.org/10.3390/medicines7010002
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author Thongprayoon, Charat
Cheungpasitporn, Wisit
Hansrivijit, Panupong
Mao, Michael A.
Medaura, Juan
Bathini, Tarun
Chewcharat, Api
Erickson, Stephen B.
author_facet Thongprayoon, Charat
Cheungpasitporn, Wisit
Hansrivijit, Panupong
Mao, Michael A.
Medaura, Juan
Bathini, Tarun
Chewcharat, Api
Erickson, Stephen B.
author_sort Thongprayoon, Charat
collection PubMed
description Background: The aim of this study was to assess the relationship between admission serum potassium and one-year mortality in all adult hospitalized patients. Methods: All adult hospitalized patients who had an admission serum potassium level between the years 2011 and 2013 at a tertiary referral hospital were enrolled. End-stage kidney disease patients were excluded. Admission serum potassium was categorized into levels of ≤2.9, 3.0–3.4, 3.5–3.9, 4.0–4.4, 4.5–4.9, 5.0–5.4, and ≥5.5 mEq/L. Cox proportional hazard analysis was performed to assess the independent association between admission serum potassium and one-year mortality after hospital admission, using an admission potassium level of 4.0–4.4 mEq/L as the reference group. Results: A total of 73,983 patients with mean admission potassium of 4.2 ± 0.5 mEq/L were studied. Of these, 12.6% died within a year after hospital admission, with the lowest one-year mortality associated with an admission serum potassium of 4.0–4.4 mEq/L. After adjustment for age, sex, race, estimated glomerular filtration rate (eGFR), principal diagnosis, comorbidities, medications, acute kidney injury, mechanical ventilation, and other electrolytes at hospital admission, both a low admission serum potassium ≤3.9 mEq/L and elevated admission potassium ≥5.0 mEq/L were significantly associated with an increased risk of one-year mortality, when compared with an admission serum potassium of 4.0–4.4 mEq/L. Subgroup analysis of chronic kidney disease and cardiovascular disease patients showed similar results. Conclusion: This study demonstrated that hypokalemia ≤3.9 mEq/L and hyperkalemia ≥5.0 mEq/L at the time of hospital admission were associated with higher one-year mortality.
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spelling pubmed-71682712020-04-22 Admission Serum Potassium Levels in Hospitalized Patients and One-Year Mortality Thongprayoon, Charat Cheungpasitporn, Wisit Hansrivijit, Panupong Mao, Michael A. Medaura, Juan Bathini, Tarun Chewcharat, Api Erickson, Stephen B. Medicines (Basel) Article Background: The aim of this study was to assess the relationship between admission serum potassium and one-year mortality in all adult hospitalized patients. Methods: All adult hospitalized patients who had an admission serum potassium level between the years 2011 and 2013 at a tertiary referral hospital were enrolled. End-stage kidney disease patients were excluded. Admission serum potassium was categorized into levels of ≤2.9, 3.0–3.4, 3.5–3.9, 4.0–4.4, 4.5–4.9, 5.0–5.4, and ≥5.5 mEq/L. Cox proportional hazard analysis was performed to assess the independent association between admission serum potassium and one-year mortality after hospital admission, using an admission potassium level of 4.0–4.4 mEq/L as the reference group. Results: A total of 73,983 patients with mean admission potassium of 4.2 ± 0.5 mEq/L were studied. Of these, 12.6% died within a year after hospital admission, with the lowest one-year mortality associated with an admission serum potassium of 4.0–4.4 mEq/L. After adjustment for age, sex, race, estimated glomerular filtration rate (eGFR), principal diagnosis, comorbidities, medications, acute kidney injury, mechanical ventilation, and other electrolytes at hospital admission, both a low admission serum potassium ≤3.9 mEq/L and elevated admission potassium ≥5.0 mEq/L were significantly associated with an increased risk of one-year mortality, when compared with an admission serum potassium of 4.0–4.4 mEq/L. Subgroup analysis of chronic kidney disease and cardiovascular disease patients showed similar results. Conclusion: This study demonstrated that hypokalemia ≤3.9 mEq/L and hyperkalemia ≥5.0 mEq/L at the time of hospital admission were associated with higher one-year mortality. MDPI 2019-12-30 /pmc/articles/PMC7168271/ /pubmed/31905856 http://dx.doi.org/10.3390/medicines7010002 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Thongprayoon, Charat
Cheungpasitporn, Wisit
Hansrivijit, Panupong
Mao, Michael A.
Medaura, Juan
Bathini, Tarun
Chewcharat, Api
Erickson, Stephen B.
Admission Serum Potassium Levels in Hospitalized Patients and One-Year Mortality
title Admission Serum Potassium Levels in Hospitalized Patients and One-Year Mortality
title_full Admission Serum Potassium Levels in Hospitalized Patients and One-Year Mortality
title_fullStr Admission Serum Potassium Levels in Hospitalized Patients and One-Year Mortality
title_full_unstemmed Admission Serum Potassium Levels in Hospitalized Patients and One-Year Mortality
title_short Admission Serum Potassium Levels in Hospitalized Patients and One-Year Mortality
title_sort admission serum potassium levels in hospitalized patients and one-year mortality
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168271/
https://www.ncbi.nlm.nih.gov/pubmed/31905856
http://dx.doi.org/10.3390/medicines7010002
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