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How Does Antimicrobial Stewardship Affect Inappropriate Antibiotic Therapy in Urological Patients?

Antimicrobial stewardship teams (ASTs) have been well-accepted in recent years; however, their clinical outcomes have not been fully investigated in urological patients. The purpose of this study was to evaluate the outcomes of intervention via a retrospective review of urological patients, as discu...

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Autores principales: Uda, Atsushi, Shigemura, Katsumi, Kitagawa, Koichi, Osawa, Kayo, Onuma, Kenichiro, Inoue, Shigeaki, Kotani, Joji, Yan, Yonmin, Nakano, Yuzo, Nishioka, Tatsuya, Yano, Ikuko, Miyara, Takayuki, Fujisawa, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168275/
https://www.ncbi.nlm.nih.gov/pubmed/32041102
http://dx.doi.org/10.3390/antibiotics9020063
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author Uda, Atsushi
Shigemura, Katsumi
Kitagawa, Koichi
Osawa, Kayo
Onuma, Kenichiro
Inoue, Shigeaki
Kotani, Joji
Yan, Yonmin
Nakano, Yuzo
Nishioka, Tatsuya
Yano, Ikuko
Miyara, Takayuki
Fujisawa, Masato
author_facet Uda, Atsushi
Shigemura, Katsumi
Kitagawa, Koichi
Osawa, Kayo
Onuma, Kenichiro
Inoue, Shigeaki
Kotani, Joji
Yan, Yonmin
Nakano, Yuzo
Nishioka, Tatsuya
Yano, Ikuko
Miyara, Takayuki
Fujisawa, Masato
author_sort Uda, Atsushi
collection PubMed
description Antimicrobial stewardship teams (ASTs) have been well-accepted in recent years; however, their clinical outcomes have not been fully investigated in urological patients. The purpose of this study was to evaluate the outcomes of intervention via a retrospective review of urological patients, as discussed in the AST meetings, who were treated with broad-spectrum antibiotics between 2014 and 2018 at the Department of Urology, Kobe University Hospital in Japan. Interventions were discussed in AST meetings for patients identified by pharmacists as having received inappropriate antibiotic therapy. The annual changes in numbers of inappropriate medications and culture submissions over five years at the urology department were statistically analyzed. Among 1,033 patients audited by pharmacists, inappropriate antibiotic therapy was found in 118 cases (11.4%). The numbers of inappropriate antibiotic use cases and of interventions for indefinite infections had significantly decreased during the study period (p = 0.012 and p = 0.033, respectively). However, the number of blood and drainage culture submissions had significantly increased (p = 0.009 and p = 0.035, respectively). Our findings suggest that urologists have probably become more familiar with infectious disease management through AST intervention, leading to a decrease in inappropriate antibiotic use and an increase in culture submissions.
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spelling pubmed-71682752020-04-22 How Does Antimicrobial Stewardship Affect Inappropriate Antibiotic Therapy in Urological Patients? Uda, Atsushi Shigemura, Katsumi Kitagawa, Koichi Osawa, Kayo Onuma, Kenichiro Inoue, Shigeaki Kotani, Joji Yan, Yonmin Nakano, Yuzo Nishioka, Tatsuya Yano, Ikuko Miyara, Takayuki Fujisawa, Masato Antibiotics (Basel) Article Antimicrobial stewardship teams (ASTs) have been well-accepted in recent years; however, their clinical outcomes have not been fully investigated in urological patients. The purpose of this study was to evaluate the outcomes of intervention via a retrospective review of urological patients, as discussed in the AST meetings, who were treated with broad-spectrum antibiotics between 2014 and 2018 at the Department of Urology, Kobe University Hospital in Japan. Interventions were discussed in AST meetings for patients identified by pharmacists as having received inappropriate antibiotic therapy. The annual changes in numbers of inappropriate medications and culture submissions over five years at the urology department were statistically analyzed. Among 1,033 patients audited by pharmacists, inappropriate antibiotic therapy was found in 118 cases (11.4%). The numbers of inappropriate antibiotic use cases and of interventions for indefinite infections had significantly decreased during the study period (p = 0.012 and p = 0.033, respectively). However, the number of blood and drainage culture submissions had significantly increased (p = 0.009 and p = 0.035, respectively). Our findings suggest that urologists have probably become more familiar with infectious disease management through AST intervention, leading to a decrease in inappropriate antibiotic use and an increase in culture submissions. MDPI 2020-02-06 /pmc/articles/PMC7168275/ /pubmed/32041102 http://dx.doi.org/10.3390/antibiotics9020063 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Uda, Atsushi
Shigemura, Katsumi
Kitagawa, Koichi
Osawa, Kayo
Onuma, Kenichiro
Inoue, Shigeaki
Kotani, Joji
Yan, Yonmin
Nakano, Yuzo
Nishioka, Tatsuya
Yano, Ikuko
Miyara, Takayuki
Fujisawa, Masato
How Does Antimicrobial Stewardship Affect Inappropriate Antibiotic Therapy in Urological Patients?
title How Does Antimicrobial Stewardship Affect Inappropriate Antibiotic Therapy in Urological Patients?
title_full How Does Antimicrobial Stewardship Affect Inappropriate Antibiotic Therapy in Urological Patients?
title_fullStr How Does Antimicrobial Stewardship Affect Inappropriate Antibiotic Therapy in Urological Patients?
title_full_unstemmed How Does Antimicrobial Stewardship Affect Inappropriate Antibiotic Therapy in Urological Patients?
title_short How Does Antimicrobial Stewardship Affect Inappropriate Antibiotic Therapy in Urological Patients?
title_sort how does antimicrobial stewardship affect inappropriate antibiotic therapy in urological patients?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168275/
https://www.ncbi.nlm.nih.gov/pubmed/32041102
http://dx.doi.org/10.3390/antibiotics9020063
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