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The Evaluation of Antibiotic Consumption at the Inpatient Level in Kazakhstan from 2011 to 2018

Antimicrobial agents have a rather special position due to their importance as essential medicines for the treatment of infectious diseases. Evidence-based prescriptions are needed to optimize the use of antimicrobials in humans, as well as to decrease antimicrobial resistance. The aim of this study...

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Autores principales: Zhussupova, Gulzira, Skvirskaya, Galina, Reshetnikov, Vladimir, Dragojevic-Simic, Viktorija, Rancic, Nemanja, Utepova, Dinara, Jakovljevic, Mihajlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168313/
https://www.ncbi.nlm.nih.gov/pubmed/32024295
http://dx.doi.org/10.3390/antibiotics9020057
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author Zhussupova, Gulzira
Skvirskaya, Galina
Reshetnikov, Vladimir
Dragojevic-Simic, Viktorija
Rancic, Nemanja
Utepova, Dinara
Jakovljevic, Mihajlo
author_facet Zhussupova, Gulzira
Skvirskaya, Galina
Reshetnikov, Vladimir
Dragojevic-Simic, Viktorija
Rancic, Nemanja
Utepova, Dinara
Jakovljevic, Mihajlo
author_sort Zhussupova, Gulzira
collection PubMed
description Antimicrobial agents have a rather special position due to their importance as essential medicines for the treatment of infectious diseases. Evidence-based prescriptions are needed to optimize the use of antimicrobials in humans, as well as to decrease antimicrobial resistance. The aim of this study was to assess the inpatient consumption of antimicrobial drugs for systemic use in the period 2011–2018 in Kazakhstan. This article presents the results of an evaluation of the inpatient use of antibacterial drugs for systemic use (group J01) for the period 2011–2018 using the anatomical therapeutic chemical (ATC) classification)/defined daily dose (DDD) methodology recommended by the World Health Organization. Inpatient antimicrobial utilization is expressed as DDDs/1000 inhabitants/day (DID). The results of the assessment for inpatient antibiotic use (over an eight-year period) showed a decrease in the total consumption of antibiotics for systemic action in Kazakhstan (2011: 12.72 DID; 2018: 2.74 DID). Among oral formulations, levofloxacin was consumed the most, and cefazolin was consumed the most among the parenteral formulations of antimicrobials. The three drugs consumed the most included cefazolin (first-generation cephalosporin), ceftriaxone (third-generation cephalosporin), and cefuroxime (second-generation cephalosporin). The total consumption of antibacterials for systemic action in Kazakhstan decreased during the analyzed period, but there was an irrational use of certain groups of drugs.
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spelling pubmed-71683132020-04-22 The Evaluation of Antibiotic Consumption at the Inpatient Level in Kazakhstan from 2011 to 2018 Zhussupova, Gulzira Skvirskaya, Galina Reshetnikov, Vladimir Dragojevic-Simic, Viktorija Rancic, Nemanja Utepova, Dinara Jakovljevic, Mihajlo Antibiotics (Basel) Article Antimicrobial agents have a rather special position due to their importance as essential medicines for the treatment of infectious diseases. Evidence-based prescriptions are needed to optimize the use of antimicrobials in humans, as well as to decrease antimicrobial resistance. The aim of this study was to assess the inpatient consumption of antimicrobial drugs for systemic use in the period 2011–2018 in Kazakhstan. This article presents the results of an evaluation of the inpatient use of antibacterial drugs for systemic use (group J01) for the period 2011–2018 using the anatomical therapeutic chemical (ATC) classification)/defined daily dose (DDD) methodology recommended by the World Health Organization. Inpatient antimicrobial utilization is expressed as DDDs/1000 inhabitants/day (DID). The results of the assessment for inpatient antibiotic use (over an eight-year period) showed a decrease in the total consumption of antibiotics for systemic action in Kazakhstan (2011: 12.72 DID; 2018: 2.74 DID). Among oral formulations, levofloxacin was consumed the most, and cefazolin was consumed the most among the parenteral formulations of antimicrobials. The three drugs consumed the most included cefazolin (first-generation cephalosporin), ceftriaxone (third-generation cephalosporin), and cefuroxime (second-generation cephalosporin). The total consumption of antibacterials for systemic action in Kazakhstan decreased during the analyzed period, but there was an irrational use of certain groups of drugs. MDPI 2020-02-02 /pmc/articles/PMC7168313/ /pubmed/32024295 http://dx.doi.org/10.3390/antibiotics9020057 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhussupova, Gulzira
Skvirskaya, Galina
Reshetnikov, Vladimir
Dragojevic-Simic, Viktorija
Rancic, Nemanja
Utepova, Dinara
Jakovljevic, Mihajlo
The Evaluation of Antibiotic Consumption at the Inpatient Level in Kazakhstan from 2011 to 2018
title The Evaluation of Antibiotic Consumption at the Inpatient Level in Kazakhstan from 2011 to 2018
title_full The Evaluation of Antibiotic Consumption at the Inpatient Level in Kazakhstan from 2011 to 2018
title_fullStr The Evaluation of Antibiotic Consumption at the Inpatient Level in Kazakhstan from 2011 to 2018
title_full_unstemmed The Evaluation of Antibiotic Consumption at the Inpatient Level in Kazakhstan from 2011 to 2018
title_short The Evaluation of Antibiotic Consumption at the Inpatient Level in Kazakhstan from 2011 to 2018
title_sort evaluation of antibiotic consumption at the inpatient level in kazakhstan from 2011 to 2018
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168313/
https://www.ncbi.nlm.nih.gov/pubmed/32024295
http://dx.doi.org/10.3390/antibiotics9020057
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