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HSD11B1 is upregulated synergistically by IFNγ and TNFα and mediates TSG-6 expression in human UC-MSCs

Inflammatory factors such as IFNγ and TNFα could endow mesenchymal stem cells (MSCs) a potent immunomodulatory property, a process called licensing, but the mechanisms are not fully understood. We here found that glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1), whi...

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Detalles Bibliográficos
Autores principales:	Huang, Peiqing, Li, Yinghong, Xu, Chenchang, Melino, Gerry, Shao, Changshun, Shi, Yufang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168568/ https://www.ncbi.nlm.nih.gov/pubmed/32328292 http://dx.doi.org/10.1038/s41420-020-0262-7

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