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Emergence of Novel Coronavirus 2019-nCoV: Need for Rapid Vaccine and Biologics Development
Novel Coronavirus (2019-nCoV) is an emerging pathogen that was first identified in Wuhan, China in late December 2019. This virus is responsible for the ongoing outbreak that causes severe respiratory illness and pneumonia-like infection in humans. Due to the increasing number of cases in China and...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168632/ https://www.ncbi.nlm.nih.gov/pubmed/32098302 http://dx.doi.org/10.3390/pathogens9020148 |
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author | Shanmugaraj, Balamurugan Malla, Ashwini Phoolcharoen, Waranyoo |
author_facet | Shanmugaraj, Balamurugan Malla, Ashwini Phoolcharoen, Waranyoo |
author_sort | Shanmugaraj, Balamurugan |
collection | PubMed |
description | Novel Coronavirus (2019-nCoV) is an emerging pathogen that was first identified in Wuhan, China in late December 2019. This virus is responsible for the ongoing outbreak that causes severe respiratory illness and pneumonia-like infection in humans. Due to the increasing number of cases in China and outside China, the WHO declared coronavirus as a global health emergency. Nearly 35,000 cases were reported and at least 24 other countries or territories have reported coronavirus cases as early on as February. Inter-human transmission was reported in a few countries, including the United States. Neither an effective anti-viral nor a vaccine is currently available to treat this infection. As the virus is a newly emerging pathogen, many questions remain unanswered regarding the virus’s reservoirs, pathogenesis, transmissibility, and much more is unknown. The collaborative efforts of researchers are needed to fill the knowledge gaps about this new virus, to develop the proper diagnostic tools, and effective treatment to combat this infection. Recent advancements in plant biotechnology proved that plants have the ability to produce vaccines or biopharmaceuticals rapidly in a short time. In this review, the outbreak of 2019-nCoV in China, the need for rapid vaccine development, and the potential of a plant system for biopharmaceutical development are discussed. |
format | Online Article Text |
id | pubmed-7168632 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71686322020-04-22 Emergence of Novel Coronavirus 2019-nCoV: Need for Rapid Vaccine and Biologics Development Shanmugaraj, Balamurugan Malla, Ashwini Phoolcharoen, Waranyoo Pathogens Review Novel Coronavirus (2019-nCoV) is an emerging pathogen that was first identified in Wuhan, China in late December 2019. This virus is responsible for the ongoing outbreak that causes severe respiratory illness and pneumonia-like infection in humans. Due to the increasing number of cases in China and outside China, the WHO declared coronavirus as a global health emergency. Nearly 35,000 cases were reported and at least 24 other countries or territories have reported coronavirus cases as early on as February. Inter-human transmission was reported in a few countries, including the United States. Neither an effective anti-viral nor a vaccine is currently available to treat this infection. As the virus is a newly emerging pathogen, many questions remain unanswered regarding the virus’s reservoirs, pathogenesis, transmissibility, and much more is unknown. The collaborative efforts of researchers are needed to fill the knowledge gaps about this new virus, to develop the proper diagnostic tools, and effective treatment to combat this infection. Recent advancements in plant biotechnology proved that plants have the ability to produce vaccines or biopharmaceuticals rapidly in a short time. In this review, the outbreak of 2019-nCoV in China, the need for rapid vaccine development, and the potential of a plant system for biopharmaceutical development are discussed. MDPI 2020-02-22 /pmc/articles/PMC7168632/ /pubmed/32098302 http://dx.doi.org/10.3390/pathogens9020148 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Shanmugaraj, Balamurugan Malla, Ashwini Phoolcharoen, Waranyoo Emergence of Novel Coronavirus 2019-nCoV: Need for Rapid Vaccine and Biologics Development |
title | Emergence of Novel Coronavirus 2019-nCoV: Need for Rapid Vaccine and Biologics Development |
title_full | Emergence of Novel Coronavirus 2019-nCoV: Need for Rapid Vaccine and Biologics Development |
title_fullStr | Emergence of Novel Coronavirus 2019-nCoV: Need for Rapid Vaccine and Biologics Development |
title_full_unstemmed | Emergence of Novel Coronavirus 2019-nCoV: Need for Rapid Vaccine and Biologics Development |
title_short | Emergence of Novel Coronavirus 2019-nCoV: Need for Rapid Vaccine and Biologics Development |
title_sort | emergence of novel coronavirus 2019-ncov: need for rapid vaccine and biologics development |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168632/ https://www.ncbi.nlm.nih.gov/pubmed/32098302 http://dx.doi.org/10.3390/pathogens9020148 |
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