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New Spotted Fever Group Rickettsia Isolate, Identified by Sequence Analysis of Conserved Genomic Regions

The clinical features of spotted fever group (SFG) Rickettsia induced disease range from a mild to severe illness. The clinical complexity is even greater due to the fact that the disease can be caused by different species with varying degrees of virulence. Current knowledge asserts that the Israeli...

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Autores principales: Klein, Dar, Beth-Din, Adi, Cohen, Regev, Lazar, Shirley, Glinert, Itai, Zayyad, Hiba, Atiya-Nasagi, Yafit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168670/
https://www.ncbi.nlm.nih.gov/pubmed/31861899
http://dx.doi.org/10.3390/pathogens9010011
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author Klein, Dar
Beth-Din, Adi
Cohen, Regev
Lazar, Shirley
Glinert, Itai
Zayyad, Hiba
Atiya-Nasagi, Yafit
author_facet Klein, Dar
Beth-Din, Adi
Cohen, Regev
Lazar, Shirley
Glinert, Itai
Zayyad, Hiba
Atiya-Nasagi, Yafit
author_sort Klein, Dar
collection PubMed
description The clinical features of spotted fever group (SFG) Rickettsia induced disease range from a mild to severe illness. The clinical complexity is even greater due to the fact that the disease can be caused by different species with varying degrees of virulence. Current knowledge asserts that the Israeli SFG (ISF) strain Rickettsia conorii israelensis is the only human pathogenic SFG member in Israel. Current diagnostic procedures distinguish between SFG and the typhus group rickettsiosis, assuming all SFG-positive clinical samples positive for ISF. Molecular studies on questing ticks over the past decade have uncovered the existence of other SFG strains besides ISF in Israel and the region. This study describes the first documented analysis of SFG-positive samples from Israeli patients with the goal of distinguishing between ISF and non-ISF SFG strains. We managed to identify a new Rickettsia isolate from three independent clinical samples in Israel which was shown to be an as-yet unknown SFG member, showing no absolute identity with any known Rickettsia species present in the NCBI database.
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spelling pubmed-71686702020-04-20 New Spotted Fever Group Rickettsia Isolate, Identified by Sequence Analysis of Conserved Genomic Regions Klein, Dar Beth-Din, Adi Cohen, Regev Lazar, Shirley Glinert, Itai Zayyad, Hiba Atiya-Nasagi, Yafit Pathogens Article The clinical features of spotted fever group (SFG) Rickettsia induced disease range from a mild to severe illness. The clinical complexity is even greater due to the fact that the disease can be caused by different species with varying degrees of virulence. Current knowledge asserts that the Israeli SFG (ISF) strain Rickettsia conorii israelensis is the only human pathogenic SFG member in Israel. Current diagnostic procedures distinguish between SFG and the typhus group rickettsiosis, assuming all SFG-positive clinical samples positive for ISF. Molecular studies on questing ticks over the past decade have uncovered the existence of other SFG strains besides ISF in Israel and the region. This study describes the first documented analysis of SFG-positive samples from Israeli patients with the goal of distinguishing between ISF and non-ISF SFG strains. We managed to identify a new Rickettsia isolate from three independent clinical samples in Israel which was shown to be an as-yet unknown SFG member, showing no absolute identity with any known Rickettsia species present in the NCBI database. MDPI 2019-12-20 /pmc/articles/PMC7168670/ /pubmed/31861899 http://dx.doi.org/10.3390/pathogens9010011 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Klein, Dar
Beth-Din, Adi
Cohen, Regev
Lazar, Shirley
Glinert, Itai
Zayyad, Hiba
Atiya-Nasagi, Yafit
New Spotted Fever Group Rickettsia Isolate, Identified by Sequence Analysis of Conserved Genomic Regions
title New Spotted Fever Group Rickettsia Isolate, Identified by Sequence Analysis of Conserved Genomic Regions
title_full New Spotted Fever Group Rickettsia Isolate, Identified by Sequence Analysis of Conserved Genomic Regions
title_fullStr New Spotted Fever Group Rickettsia Isolate, Identified by Sequence Analysis of Conserved Genomic Regions
title_full_unstemmed New Spotted Fever Group Rickettsia Isolate, Identified by Sequence Analysis of Conserved Genomic Regions
title_short New Spotted Fever Group Rickettsia Isolate, Identified by Sequence Analysis of Conserved Genomic Regions
title_sort new spotted fever group rickettsia isolate, identified by sequence analysis of conserved genomic regions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168670/
https://www.ncbi.nlm.nih.gov/pubmed/31861899
http://dx.doi.org/10.3390/pathogens9010011
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