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Lighter serum copper isotopic composition in patients with early non-alcoholic fatty liver disease
OBJECTIVE: The occurrence of non-alcoholic fatty liver disease (NAFLD) is globally increasing. To challenge the current incidence of NAFLD, non-invasive markers that could identify patients at risk or monitor disease progression are an important need. Copper intake and organ copper concentrations ha...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168815/ https://www.ncbi.nlm.nih.gov/pubmed/32306999 http://dx.doi.org/10.1186/s13104-020-05069-3 |
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author | Van Campenhout, Sanne Hastuti, Agustina A. M. B. Lefere, Sander Van Vlierberghe, Hans Vanhaecke, Frank Costas-Rodríguez, Marta Devisscher, Lindsey |
author_facet | Van Campenhout, Sanne Hastuti, Agustina A. M. B. Lefere, Sander Van Vlierberghe, Hans Vanhaecke, Frank Costas-Rodríguez, Marta Devisscher, Lindsey |
author_sort | Van Campenhout, Sanne |
collection | PubMed |
description | OBJECTIVE: The occurrence of non-alcoholic fatty liver disease (NAFLD) is globally increasing. To challenge the current incidence of NAFLD, non-invasive markers that could identify patients at risk or monitor disease progression are an important need. Copper intake and organ copper concentrations have earlier been linked to NAFLD progression, but serum copper does not adequately represent the disease state. Cu atoms occur under the form of two stable isotopes, (63)Cu and (65)Cu, and the ratio of both (expressed as δ(65)Cu, in ‰) in blood serum has been shown to be altered in chronic liver disease. To assess whether the Cu isotope ratio might predict disease occurrence and progression of NAFLD, the serum Cu isotopic composition of patients with different stages of NAFLD was determined. RESULTS: Our results showed that serum δ(65)Cu values were lower in NAFLD patients, already at the level of simple steatosis, and remained stable during further disease progression. ROC analysis shows an almost perfect diagnostic ability of serum δ(65)Cu values for NAFLD, but no discrimination between different severity degrees could be made. Therefore, the serum Cu isotopic composition might show potential for early diagnosis of NAFLD patients. |
format | Online Article Text |
id | pubmed-7168815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-71688152020-04-23 Lighter serum copper isotopic composition in patients with early non-alcoholic fatty liver disease Van Campenhout, Sanne Hastuti, Agustina A. M. B. Lefere, Sander Van Vlierberghe, Hans Vanhaecke, Frank Costas-Rodríguez, Marta Devisscher, Lindsey BMC Res Notes Research Note OBJECTIVE: The occurrence of non-alcoholic fatty liver disease (NAFLD) is globally increasing. To challenge the current incidence of NAFLD, non-invasive markers that could identify patients at risk or monitor disease progression are an important need. Copper intake and organ copper concentrations have earlier been linked to NAFLD progression, but serum copper does not adequately represent the disease state. Cu atoms occur under the form of two stable isotopes, (63)Cu and (65)Cu, and the ratio of both (expressed as δ(65)Cu, in ‰) in blood serum has been shown to be altered in chronic liver disease. To assess whether the Cu isotope ratio might predict disease occurrence and progression of NAFLD, the serum Cu isotopic composition of patients with different stages of NAFLD was determined. RESULTS: Our results showed that serum δ(65)Cu values were lower in NAFLD patients, already at the level of simple steatosis, and remained stable during further disease progression. ROC analysis shows an almost perfect diagnostic ability of serum δ(65)Cu values for NAFLD, but no discrimination between different severity degrees could be made. Therefore, the serum Cu isotopic composition might show potential for early diagnosis of NAFLD patients. BioMed Central 2020-04-19 /pmc/articles/PMC7168815/ /pubmed/32306999 http://dx.doi.org/10.1186/s13104-020-05069-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Note Van Campenhout, Sanne Hastuti, Agustina A. M. B. Lefere, Sander Van Vlierberghe, Hans Vanhaecke, Frank Costas-Rodríguez, Marta Devisscher, Lindsey Lighter serum copper isotopic composition in patients with early non-alcoholic fatty liver disease |
title | Lighter serum copper isotopic composition in patients with early non-alcoholic fatty liver disease |
title_full | Lighter serum copper isotopic composition in patients with early non-alcoholic fatty liver disease |
title_fullStr | Lighter serum copper isotopic composition in patients with early non-alcoholic fatty liver disease |
title_full_unstemmed | Lighter serum copper isotopic composition in patients with early non-alcoholic fatty liver disease |
title_short | Lighter serum copper isotopic composition in patients with early non-alcoholic fatty liver disease |
title_sort | lighter serum copper isotopic composition in patients with early non-alcoholic fatty liver disease |
topic | Research Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168815/ https://www.ncbi.nlm.nih.gov/pubmed/32306999 http://dx.doi.org/10.1186/s13104-020-05069-3 |
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