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Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome
BACKGROUND: In myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), altered membrane excitability often occurs in exercising muscles demonstrating muscle dysfunction regardless of any psychiatric disorder. Increased oxidative stress is also present in many ME/CFS patients and could affect th...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168976/ https://www.ncbi.nlm.nih.gov/pubmed/32306967 http://dx.doi.org/10.1186/s12967-020-02341-9 |
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author | Jammes, Yves Adjriou, Nabil Kipson, Nathalie Criado, Christine Charpin, Caroline Rebaudet, Stanislas Stavris, Chloé Guieu, Régis Fenouillet, Emmanuel Retornaz, Frédérique |
author_facet | Jammes, Yves Adjriou, Nabil Kipson, Nathalie Criado, Christine Charpin, Caroline Rebaudet, Stanislas Stavris, Chloé Guieu, Régis Fenouillet, Emmanuel Retornaz, Frédérique |
author_sort | Jammes, Yves |
collection | PubMed |
description | BACKGROUND: In myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), altered membrane excitability often occurs in exercising muscles demonstrating muscle dysfunction regardless of any psychiatric disorder. Increased oxidative stress is also present in many ME/CFS patients and could affect the membrane excitability of resting muscles. METHODS: Seventy-two patients were examined at rest, during an incremental cycling exercise and during a 10-min post-exercise recovery period. All patients had at least four criteria leading to a diagnosis of ME/CFS. To explore muscle membrane excitability, M-waves were recorded during exercise (rectus femoris (RF) muscle) and at rest (flexor digitorum longus (FDL) muscle). Two plasma markers of oxidative stress (thiobarbituric acid reactive substance (TBARS) and oxidation–reduction potential (ORP)) were measured. Plasma potassium (K(+)) concentration was also measured at rest and at the end of exercise to explore K(+) outflow. RESULTS: Thirty-nine patients had marked M-wave alterations in both the RF and FDL muscles during and after exercise while the resting values of plasma TBARS and ORP were increased and exercise-induced K(+) outflow was decreased. In contrast, 33 other patients with a diagnosis of ME/CFS had no M-wave alterations and had lower baseline levels of TBARS and ORP. M-wave changes were inversely proportional to TBARS and ORP levels. CONCLUSIONS: Resting muscles of ME/CFS patients have altered muscle membrane excitability. However, our data reveal heterogeneity in some major biomarkers in ME/CFS patients. Measurement of ORP may help to improve the diagnosis of ME/CFS. Trial registration Ethics Committee “Ouest II” of Angers (May 17, 2019) RCB ID: number 2019-A00611-56 |
format | Online Article Text |
id | pubmed-7168976 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-71689762020-04-23 Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome Jammes, Yves Adjriou, Nabil Kipson, Nathalie Criado, Christine Charpin, Caroline Rebaudet, Stanislas Stavris, Chloé Guieu, Régis Fenouillet, Emmanuel Retornaz, Frédérique J Transl Med Research BACKGROUND: In myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), altered membrane excitability often occurs in exercising muscles demonstrating muscle dysfunction regardless of any psychiatric disorder. Increased oxidative stress is also present in many ME/CFS patients and could affect the membrane excitability of resting muscles. METHODS: Seventy-two patients were examined at rest, during an incremental cycling exercise and during a 10-min post-exercise recovery period. All patients had at least four criteria leading to a diagnosis of ME/CFS. To explore muscle membrane excitability, M-waves were recorded during exercise (rectus femoris (RF) muscle) and at rest (flexor digitorum longus (FDL) muscle). Two plasma markers of oxidative stress (thiobarbituric acid reactive substance (TBARS) and oxidation–reduction potential (ORP)) were measured. Plasma potassium (K(+)) concentration was also measured at rest and at the end of exercise to explore K(+) outflow. RESULTS: Thirty-nine patients had marked M-wave alterations in both the RF and FDL muscles during and after exercise while the resting values of plasma TBARS and ORP were increased and exercise-induced K(+) outflow was decreased. In contrast, 33 other patients with a diagnosis of ME/CFS had no M-wave alterations and had lower baseline levels of TBARS and ORP. M-wave changes were inversely proportional to TBARS and ORP levels. CONCLUSIONS: Resting muscles of ME/CFS patients have altered muscle membrane excitability. However, our data reveal heterogeneity in some major biomarkers in ME/CFS patients. Measurement of ORP may help to improve the diagnosis of ME/CFS. Trial registration Ethics Committee “Ouest II” of Angers (May 17, 2019) RCB ID: number 2019-A00611-56 BioMed Central 2020-04-19 /pmc/articles/PMC7168976/ /pubmed/32306967 http://dx.doi.org/10.1186/s12967-020-02341-9 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Jammes, Yves Adjriou, Nabil Kipson, Nathalie Criado, Christine Charpin, Caroline Rebaudet, Stanislas Stavris, Chloé Guieu, Régis Fenouillet, Emmanuel Retornaz, Frédérique Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome |
title | Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome |
title_full | Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome |
title_fullStr | Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome |
title_full_unstemmed | Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome |
title_short | Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome |
title_sort | altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168976/ https://www.ncbi.nlm.nih.gov/pubmed/32306967 http://dx.doi.org/10.1186/s12967-020-02341-9 |
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