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Negative chronotropic and inotropic effects of lubiprostone on iPS cell-derived cardiomyocytes via activation of CFTR

BACKGROUND: Lubiprostone (LBP) is a novel chloride channel opener that has been reported to activate chloride channel protein 2 (ClC-2) and cystic fibrosis transmembrane conductance regulator (CFTR). LBP facilitates fluid secretion by activating CFTR in the intestine and is used as a drug for treati...

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Detalles Bibliográficos
Autores principales:	Akita, Hiraku, Yoshie, Susumu, Ishida, Takafumi, Takeishi, Yasuchika, Hazama, Akihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169008/ https://www.ncbi.nlm.nih.gov/pubmed/32306956 http://dx.doi.org/10.1186/s12906-020-02923-6

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