A Fast and Simple Method for the Determination of TBA in (18)F-Labeled Radiopharmaceuticals

A simple color spot test for determining the presence of residual tetrabutylammonium (TBA) in various (18)F-radiopharmaceuticals is described. The test can be performed in less than five minutes. Iodoplatinate-saturated TLC plates are initially spotted with the (18)F-radiopharmaceutical to be tested...

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Autores principales: Halvorsen, Nils Erik, Kvernenes, Ole Heine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169447/
https://www.ncbi.nlm.nih.gov/pubmed/32054093
http://dx.doi.org/10.3390/ph13020027
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author Halvorsen, Nils Erik
Kvernenes, Ole Heine
author_facet Halvorsen, Nils Erik
Kvernenes, Ole Heine
author_sort Halvorsen, Nils Erik
collection PubMed
description A simple color spot test for determining the presence of residual tetrabutylammonium (TBA) in various (18)F-radiopharmaceuticals is described. The test can be performed in less than five minutes. Iodoplatinate-saturated TLC plates are initially spotted with the (18)F-radiopharmaceutical to be tested and TBA, then with deionized water or hydrogen peroxide (H(2)O(2)) solution, depending on if an antioxidant stabilizer is part of the pharmaceutical matrix. A distinct brown spot is visible at TBA concentrations of 50 µg/mL and up.
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spelling pubmed-71694472020-04-22 A Fast and Simple Method for the Determination of TBA in (18)F-Labeled Radiopharmaceuticals Halvorsen, Nils Erik Kvernenes, Ole Heine Pharmaceuticals (Basel) Technical Note A simple color spot test for determining the presence of residual tetrabutylammonium (TBA) in various (18)F-radiopharmaceuticals is described. The test can be performed in less than five minutes. Iodoplatinate-saturated TLC plates are initially spotted with the (18)F-radiopharmaceutical to be tested and TBA, then with deionized water or hydrogen peroxide (H(2)O(2)) solution, depending on if an antioxidant stabilizer is part of the pharmaceutical matrix. A distinct brown spot is visible at TBA concentrations of 50 µg/mL and up. MDPI 2020-02-11 /pmc/articles/PMC7169447/ /pubmed/32054093 http://dx.doi.org/10.3390/ph13020027 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Technical Note
Halvorsen, Nils Erik
Kvernenes, Ole Heine
A Fast and Simple Method for the Determination of TBA in (18)F-Labeled Radiopharmaceuticals
title A Fast and Simple Method for the Determination of TBA in (18)F-Labeled Radiopharmaceuticals
title_full A Fast and Simple Method for the Determination of TBA in (18)F-Labeled Radiopharmaceuticals
title_fullStr A Fast and Simple Method for the Determination of TBA in (18)F-Labeled Radiopharmaceuticals
title_full_unstemmed A Fast and Simple Method for the Determination of TBA in (18)F-Labeled Radiopharmaceuticals
title_short A Fast and Simple Method for the Determination of TBA in (18)F-Labeled Radiopharmaceuticals
title_sort fast and simple method for the determination of tba in (18)f-labeled radiopharmaceuticals
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169447/
https://www.ncbi.nlm.nih.gov/pubmed/32054093
http://dx.doi.org/10.3390/ph13020027
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