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Clinico-Pathological Presentations of Cystic and Classic Adenomatoid Odontogenic Tumors
The objective of the study is to present the clinico-pathological features of cystic and classic adenomatoid odontogenic tumors (AOTs) in order to identify the differences between the two variants of AOT. Materials and method: The study sample comprised of 41 AOTs, which were categorized into cystic...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169454/ https://www.ncbi.nlm.nih.gov/pubmed/31861900 http://dx.doi.org/10.3390/diagnostics10010003 |
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author | Jayasooriya, Primali Rukmal Rambukewella, Inoka Krishanthi Tilakaratne, Wanninayake Mudiyanselage Mendis, Balapuwaduge Ranjit Rigobert Nihal Lombardi, Tommaso |
author_facet | Jayasooriya, Primali Rukmal Rambukewella, Inoka Krishanthi Tilakaratne, Wanninayake Mudiyanselage Mendis, Balapuwaduge Ranjit Rigobert Nihal Lombardi, Tommaso |
author_sort | Jayasooriya, Primali Rukmal |
collection | PubMed |
description | The objective of the study is to present the clinico-pathological features of cystic and classic adenomatoid odontogenic tumors (AOTs) in order to identify the differences between the two variants of AOT. Materials and method: The study sample comprised of 41 AOTs, which were categorized into cystic and classic AOTs. Cystic AOTs are diagnosed as such when macroscopic and microscopic evidence of a cyst is present together with histopathological criteria of AOT (WHO–2017). Results: The study sample comprised of eleven cystic and thirty classic AOTs. Eight cystic AOTs were regarded as arising from dentigerous cysts as these lesions were attached to the cemento-enamel junction of the impacted teeth. Though not statistically significant, in contrast to classic AOTs which showed female predilection, cystic AOTs were more prevalent in males. Cystic AOTs tend to present as significantly larger lesions compared to classic AOTs (p < 0.02). In both cystic and classic AOTs, duct-like structures and epithelial whorls were the two most prominent histopathological features present in the majority of tumors. Two AOTs with massive amounts of dentinoid occurred in the mandible and presented as large lesions that eroded cortical bone. None of the 12 patients with follow-up information presented with recurrences. Conclusion: Except for the size of the lesion, no significant clinico-pathological differences were observed between cystic and classic AOTs. Therefore the cystic AOTs can be considered as a variant of AOT with enucleation, simple excision, or radical excision as the treatment of choice depending on the extent of the lesion, similar to classic AOTs. |
format | Online Article Text |
id | pubmed-7169454 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71694542020-04-22 Clinico-Pathological Presentations of Cystic and Classic Adenomatoid Odontogenic Tumors Jayasooriya, Primali Rukmal Rambukewella, Inoka Krishanthi Tilakaratne, Wanninayake Mudiyanselage Mendis, Balapuwaduge Ranjit Rigobert Nihal Lombardi, Tommaso Diagnostics (Basel) Article The objective of the study is to present the clinico-pathological features of cystic and classic adenomatoid odontogenic tumors (AOTs) in order to identify the differences between the two variants of AOT. Materials and method: The study sample comprised of 41 AOTs, which were categorized into cystic and classic AOTs. Cystic AOTs are diagnosed as such when macroscopic and microscopic evidence of a cyst is present together with histopathological criteria of AOT (WHO–2017). Results: The study sample comprised of eleven cystic and thirty classic AOTs. Eight cystic AOTs were regarded as arising from dentigerous cysts as these lesions were attached to the cemento-enamel junction of the impacted teeth. Though not statistically significant, in contrast to classic AOTs which showed female predilection, cystic AOTs were more prevalent in males. Cystic AOTs tend to present as significantly larger lesions compared to classic AOTs (p < 0.02). In both cystic and classic AOTs, duct-like structures and epithelial whorls were the two most prominent histopathological features present in the majority of tumors. Two AOTs with massive amounts of dentinoid occurred in the mandible and presented as large lesions that eroded cortical bone. None of the 12 patients with follow-up information presented with recurrences. Conclusion: Except for the size of the lesion, no significant clinico-pathological differences were observed between cystic and classic AOTs. Therefore the cystic AOTs can be considered as a variant of AOT with enucleation, simple excision, or radical excision as the treatment of choice depending on the extent of the lesion, similar to classic AOTs. MDPI 2019-12-20 /pmc/articles/PMC7169454/ /pubmed/31861900 http://dx.doi.org/10.3390/diagnostics10010003 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jayasooriya, Primali Rukmal Rambukewella, Inoka Krishanthi Tilakaratne, Wanninayake Mudiyanselage Mendis, Balapuwaduge Ranjit Rigobert Nihal Lombardi, Tommaso Clinico-Pathological Presentations of Cystic and Classic Adenomatoid Odontogenic Tumors |
title | Clinico-Pathological Presentations of Cystic and Classic Adenomatoid Odontogenic Tumors |
title_full | Clinico-Pathological Presentations of Cystic and Classic Adenomatoid Odontogenic Tumors |
title_fullStr | Clinico-Pathological Presentations of Cystic and Classic Adenomatoid Odontogenic Tumors |
title_full_unstemmed | Clinico-Pathological Presentations of Cystic and Classic Adenomatoid Odontogenic Tumors |
title_short | Clinico-Pathological Presentations of Cystic and Classic Adenomatoid Odontogenic Tumors |
title_sort | clinico-pathological presentations of cystic and classic adenomatoid odontogenic tumors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169454/ https://www.ncbi.nlm.nih.gov/pubmed/31861900 http://dx.doi.org/10.3390/diagnostics10010003 |
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