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Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals
This article examines three aspects of antivirals, such as hydroxychloroquine, chloroquine, and remdesvir, as they might relate to the treatment of a viral infection such as COVID-19: (i) the use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficac...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169894/ https://www.ncbi.nlm.nih.gov/pubmed/32325124 http://dx.doi.org/10.1016/j.drudis.2020.04.010 |
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author | Manning, Thomas J. Thomas-Richardson, Jenu Cowan, Matthew Beard, Torien |
author_facet | Manning, Thomas J. Thomas-Richardson, Jenu Cowan, Matthew Beard, Torien |
author_sort | Manning, Thomas J. |
collection | PubMed |
description | This article examines three aspects of antivirals, such as hydroxychloroquine, chloroquine, and remdesvir, as they might relate to the treatment of a viral infection such as COVID-19: (i) the use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficacy; (ii) the application of a marine natural product extract as opposed to a single molecule as an antiviral agent; and (iii) a counter intuitive approach to formulation that is, in part, based on delivering multiple species that fall into three categories: building blocks for the virus to accelerate replication; an energy source for the infected cell to boost its immune response; and the species that antagonize or provide toxicity to the virus. |
format | Online Article Text |
id | pubmed-7169894 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71698942020-04-21 Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals Manning, Thomas J. Thomas-Richardson, Jenu Cowan, Matthew Beard, Torien Drug Discov Today Article This article examines three aspects of antivirals, such as hydroxychloroquine, chloroquine, and remdesvir, as they might relate to the treatment of a viral infection such as COVID-19: (i) the use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficacy; (ii) the application of a marine natural product extract as opposed to a single molecule as an antiviral agent; and (iii) a counter intuitive approach to formulation that is, in part, based on delivering multiple species that fall into three categories: building blocks for the virus to accelerate replication; an energy source for the infected cell to boost its immune response; and the species that antagonize or provide toxicity to the virus. Elsevier Ltd. 2020-06 2020-04-20 /pmc/articles/PMC7169894/ /pubmed/32325124 http://dx.doi.org/10.1016/j.drudis.2020.04.010 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Manning, Thomas J. Thomas-Richardson, Jenu Cowan, Matthew Beard, Torien Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals |
title | Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals |
title_full | Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals |
title_fullStr | Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals |
title_full_unstemmed | Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals |
title_short | Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals |
title_sort | vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169894/ https://www.ncbi.nlm.nih.gov/pubmed/32325124 http://dx.doi.org/10.1016/j.drudis.2020.04.010 |
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