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Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals

This article examines three aspects of antivirals, such as hydroxychloroquine, chloroquine, and remdesvir, as they might relate to the treatment of a viral infection such as COVID-19: (i) the use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficac...

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Detalles Bibliográficos
Autores principales: Manning, Thomas J., Thomas-Richardson, Jenu, Cowan, Matthew, Beard, Torien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169894/
https://www.ncbi.nlm.nih.gov/pubmed/32325124
http://dx.doi.org/10.1016/j.drudis.2020.04.010
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author Manning, Thomas J.
Thomas-Richardson, Jenu
Cowan, Matthew
Beard, Torien
author_facet Manning, Thomas J.
Thomas-Richardson, Jenu
Cowan, Matthew
Beard, Torien
author_sort Manning, Thomas J.
collection PubMed
description This article examines three aspects of antivirals, such as hydroxychloroquine, chloroquine, and remdesvir, as they might relate to the treatment of a viral infection such as COVID-19: (i) the use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficacy; (ii) the application of a marine natural product extract as opposed to a single molecule as an antiviral agent; and (iii) a counter intuitive approach to formulation that is, in part, based on delivering multiple species that fall into three categories: building blocks for the virus to accelerate replication; an energy source for the infected cell to boost its immune response; and the species that antagonize or provide toxicity to the virus.
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spelling pubmed-71698942020-04-21 Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals Manning, Thomas J. Thomas-Richardson, Jenu Cowan, Matthew Beard, Torien Drug Discov Today Article This article examines three aspects of antivirals, such as hydroxychloroquine, chloroquine, and remdesvir, as they might relate to the treatment of a viral infection such as COVID-19: (i) the use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficacy; (ii) the application of a marine natural product extract as opposed to a single molecule as an antiviral agent; and (iii) a counter intuitive approach to formulation that is, in part, based on delivering multiple species that fall into three categories: building blocks for the virus to accelerate replication; an energy source for the infected cell to boost its immune response; and the species that antagonize or provide toxicity to the virus. Elsevier Ltd. 2020-06 2020-04-20 /pmc/articles/PMC7169894/ /pubmed/32325124 http://dx.doi.org/10.1016/j.drudis.2020.04.010 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Manning, Thomas J.
Thomas-Richardson, Jenu
Cowan, Matthew
Beard, Torien
Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals
title Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals
title_full Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals
title_fullStr Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals
title_full_unstemmed Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals
title_short Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals
title_sort vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169894/
https://www.ncbi.nlm.nih.gov/pubmed/32325124
http://dx.doi.org/10.1016/j.drudis.2020.04.010
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AT beardtorien vaporizationbioactiveformulationsandamarinenaturalproductdifferentperspectivesonantivirals