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Increased prevalence of endocervical Mycoplasma and Ureaplasma colonization in infertile women with tubal factor

OBJECTIVE: Most women suffering from tubal factor infertility do not have a history of pelvic inflammatory disease, but rather have asymptomatic upper genital tract infection. Investigating the impacts of such infections, even in the absence of clinically confirmed pelvic inflammatory disease, is cr...

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Autores principales: Piscopo, Rita CCP, Guimarães, Ronney V, Ueno, Joji, Ikeda, Fabio, Bella, Zsuzsanna IK Jarmy-Di, Girão, Manoel JBC, Samama, Marise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Brazilian Society of Assisted Reproduction 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169909/
https://www.ncbi.nlm.nih.gov/pubmed/32031768
http://dx.doi.org/10.5935/1518-0557.20190078
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author Piscopo, Rita CCP
Guimarães, Ronney V
Ueno, Joji
Ikeda, Fabio
Bella, Zsuzsanna IK Jarmy-Di
Girão, Manoel JBC
Samama, Marise
author_facet Piscopo, Rita CCP
Guimarães, Ronney V
Ueno, Joji
Ikeda, Fabio
Bella, Zsuzsanna IK Jarmy-Di
Girão, Manoel JBC
Samama, Marise
author_sort Piscopo, Rita CCP
collection PubMed
description OBJECTIVE: Most women suffering from tubal factor infertility do not have a history of pelvic inflammatory disease, but rather have asymptomatic upper genital tract infection. Investigating the impacts of such infections, even in the absence of clinically confirmed pelvic inflammatory disease, is critical to understanding the tubal factor of infertility. The aim of this study was to investigate whether the presence of endocervical bacteria is associated with tubal factors in women screened for infertility. METHODS: This retrospective cross-sectional study involved 245 women undergoing hysterosalpingography (HSG), screened for endocervical colonization by Chlamydia trachomatis, Neisseria gonorrhea, Ureaplasma urealyticum and Mycoplasma hominis, as part of a routine female infertility investigation between 2016 and 2017. RESULTS: endocervical bacterial colonization by Chlamydia trachomatis, Ureaplasma urealiticum, Mycoplasma hominis and other bacteria corresponded to 3.7%, 9.0%; 5.7% and 9.8%, respectively. There was no colonization by Neisseria gonorrhea. The prevalence of tubal factor was significantly higher in patients with positive endocervical bacteria colonization, regardless of bacterial species. When evaluating bacteria species individually, the women who were positive for endocervical Mycoplasma hominis had significantly higher rates of tubal factor. Associations between endocervical bacterial colonization and tubal factor infertility were confirmed by multiple regression analysis adjusted for age and duration of infertility. CONCLUSION: Besides the higher prevalence of Mycoplasma and Ureaplasma infectious agents, the findings of this study suggest the possible association of endocervical bacterial colonization - not only Chlamydia trachomatis and Neisseria gonorrhea, but also Mycoplasma species with tubal performance.
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spelling pubmed-71699092020-04-24 Increased prevalence of endocervical Mycoplasma and Ureaplasma colonization in infertile women with tubal factor Piscopo, Rita CCP Guimarães, Ronney V Ueno, Joji Ikeda, Fabio Bella, Zsuzsanna IK Jarmy-Di Girão, Manoel JBC Samama, Marise JBRA Assist Reprod Original Article OBJECTIVE: Most women suffering from tubal factor infertility do not have a history of pelvic inflammatory disease, but rather have asymptomatic upper genital tract infection. Investigating the impacts of such infections, even in the absence of clinically confirmed pelvic inflammatory disease, is critical to understanding the tubal factor of infertility. The aim of this study was to investigate whether the presence of endocervical bacteria is associated with tubal factors in women screened for infertility. METHODS: This retrospective cross-sectional study involved 245 women undergoing hysterosalpingography (HSG), screened for endocervical colonization by Chlamydia trachomatis, Neisseria gonorrhea, Ureaplasma urealyticum and Mycoplasma hominis, as part of a routine female infertility investigation between 2016 and 2017. RESULTS: endocervical bacterial colonization by Chlamydia trachomatis, Ureaplasma urealiticum, Mycoplasma hominis and other bacteria corresponded to 3.7%, 9.0%; 5.7% and 9.8%, respectively. There was no colonization by Neisseria gonorrhea. The prevalence of tubal factor was significantly higher in patients with positive endocervical bacteria colonization, regardless of bacterial species. When evaluating bacteria species individually, the women who were positive for endocervical Mycoplasma hominis had significantly higher rates of tubal factor. Associations between endocervical bacterial colonization and tubal factor infertility were confirmed by multiple regression analysis adjusted for age and duration of infertility. CONCLUSION: Besides the higher prevalence of Mycoplasma and Ureaplasma infectious agents, the findings of this study suggest the possible association of endocervical bacterial colonization - not only Chlamydia trachomatis and Neisseria gonorrhea, but also Mycoplasma species with tubal performance. Brazilian Society of Assisted Reproduction 2020 /pmc/articles/PMC7169909/ /pubmed/32031768 http://dx.doi.org/10.5935/1518-0557.20190078 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Piscopo, Rita CCP
Guimarães, Ronney V
Ueno, Joji
Ikeda, Fabio
Bella, Zsuzsanna IK Jarmy-Di
Girão, Manoel JBC
Samama, Marise
Increased prevalence of endocervical Mycoplasma and Ureaplasma colonization in infertile women with tubal factor
title Increased prevalence of endocervical Mycoplasma and Ureaplasma colonization in infertile women with tubal factor
title_full Increased prevalence of endocervical Mycoplasma and Ureaplasma colonization in infertile women with tubal factor
title_fullStr Increased prevalence of endocervical Mycoplasma and Ureaplasma colonization in infertile women with tubal factor
title_full_unstemmed Increased prevalence of endocervical Mycoplasma and Ureaplasma colonization in infertile women with tubal factor
title_short Increased prevalence of endocervical Mycoplasma and Ureaplasma colonization in infertile women with tubal factor
title_sort increased prevalence of endocervical mycoplasma and ureaplasma colonization in infertile women with tubal factor
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169909/
https://www.ncbi.nlm.nih.gov/pubmed/32031768
http://dx.doi.org/10.5935/1518-0557.20190078
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