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EP4 activation ameliorates liver ischemia/reperfusion injury via ERK1/2-GSK3β-dependent MPTP inhibition

Prostaglandin E receptor subtype 4 (EP4) is widely distributed in the heart, but its role in hepatic ischemia/reperfusion (I/R), particularly in mitochondrial permeability transition pore (MPTP) modulation, is yet to be elucidated. In the present study, an EP4 agonist (CAY10598) was used in a rat mo...

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Detalles Bibliográficos
Autores principales:	Cai, Lin-Lin, Xu, Hai-Tao, Wang, Qi-Long, Zhang, Ya-Qing, Chen, Wei, Zheng, Dong-Yu, Liu, Fang, Yuan, Hong-Bin, Li, Yong-Hua, Fu, Hai-Long
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169940/ https://www.ncbi.nlm.nih.gov/pubmed/32186754 http://dx.doi.org/10.3892/ijmm.2020.4544

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