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Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study

Inhalation of mineral dust was suggested to contribute to sarcoidosis. We compared the mineral exposome of 20 sarcoidosis and 20 matched healthy subjects. Bronchoalveolar lavage (BAL) samples were treated by digestion-filtration and analyzed by transmission electron microscopy. The chemical composit...

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Autores principales: Catinon*, Mickael, Cavalin, Catherine, Chemarin, Cécile, Rio, Stéphane, Roux, Elisabeth, Pecquet, Mathieu, Blanchet, Anne-Sophie, Vuillermoz, Sylvie, Pison, Christophe, Arbib, François, Bonneterre, Vincent, Valeyre, Dominique, Freynet, Olivia, Mornex, Jean-François, Pacheco, Yves, Freymond, Nathalie, Thivolet, Françoise, Kambouchner, Marianne, Bernaudin, Jean-François, Nathalizio, Audrey, Pradat, Pierre, Rosental, Paul-André, Vincent, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mattioli 1885 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170131/
https://www.ncbi.nlm.nih.gov/pubmed/32476920
http://dx.doi.org/10.36141/svdld.v35i4.7058
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author Catinon*, Mickael
Cavalin, Catherine
Chemarin, Cécile
Rio, Stéphane
Roux, Elisabeth
Pecquet, Mathieu
Blanchet, Anne-Sophie
Vuillermoz, Sylvie
Pison, Christophe
Arbib, François
Bonneterre, Vincent
Valeyre, Dominique
Freynet, Olivia
Mornex, Jean-François
Pacheco, Yves
Freymond, Nathalie
Thivolet, Françoise
Kambouchner, Marianne
Bernaudin, Jean-François
Nathalizio, Audrey
Pradat, Pierre
Rosental, Paul-André
Vincent, Michel
author_facet Catinon*, Mickael
Cavalin, Catherine
Chemarin, Cécile
Rio, Stéphane
Roux, Elisabeth
Pecquet, Mathieu
Blanchet, Anne-Sophie
Vuillermoz, Sylvie
Pison, Christophe
Arbib, François
Bonneterre, Vincent
Valeyre, Dominique
Freynet, Olivia
Mornex, Jean-François
Pacheco, Yves
Freymond, Nathalie
Thivolet, Françoise
Kambouchner, Marianne
Bernaudin, Jean-François
Nathalizio, Audrey
Pradat, Pierre
Rosental, Paul-André
Vincent, Michel
author_sort Catinon*, Mickael
collection PubMed
description Inhalation of mineral dust was suggested to contribute to sarcoidosis. We compared the mineral exposome of 20 sarcoidosis and 20 matched healthy subjects. Bronchoalveolar lavage (BAL) samples were treated by digestion-filtration and analyzed by transmission electron microscopy. The chemical composition of inorganic particles was determined by energy-dispersive X-ray (EDX) spectroscopy. Dust exposure was also assessed by a specific questionnaire. Eight sarcoidosis patients and five healthy volunteers had a high dust load in their BAL. No significant difference was observed between the overall inorganic particle load of each group while a significant higher load for steel was observed in sarcoidosis patients (p=0.029). Moreover, the building activity sub-score was significantly higher in sarcoidosis patients (p=0.018). These results suggest that building work could be a risk factor for sarcoidosis which could be considered at least in some cases as a granulomatosis caused by airborne inorganic dust. The questionnaire should be validated in larger studies. (Sarcoidosis Vasc Diffuse Lung Dis 2018; 35: 327-332)
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spelling pubmed-71701312020-05-29 Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study Catinon*, Mickael Cavalin, Catherine Chemarin, Cécile Rio, Stéphane Roux, Elisabeth Pecquet, Mathieu Blanchet, Anne-Sophie Vuillermoz, Sylvie Pison, Christophe Arbib, François Bonneterre, Vincent Valeyre, Dominique Freynet, Olivia Mornex, Jean-François Pacheco, Yves Freymond, Nathalie Thivolet, Françoise Kambouchner, Marianne Bernaudin, Jean-François Nathalizio, Audrey Pradat, Pierre Rosental, Paul-André Vincent, Michel Sarcoidosis Vasc Diffuse Lung Dis Original Article: Clinical Research Inhalation of mineral dust was suggested to contribute to sarcoidosis. We compared the mineral exposome of 20 sarcoidosis and 20 matched healthy subjects. Bronchoalveolar lavage (BAL) samples were treated by digestion-filtration and analyzed by transmission electron microscopy. The chemical composition of inorganic particles was determined by energy-dispersive X-ray (EDX) spectroscopy. Dust exposure was also assessed by a specific questionnaire. Eight sarcoidosis patients and five healthy volunteers had a high dust load in their BAL. No significant difference was observed between the overall inorganic particle load of each group while a significant higher load for steel was observed in sarcoidosis patients (p=0.029). Moreover, the building activity sub-score was significantly higher in sarcoidosis patients (p=0.018). These results suggest that building work could be a risk factor for sarcoidosis which could be considered at least in some cases as a granulomatosis caused by airborne inorganic dust. The questionnaire should be validated in larger studies. (Sarcoidosis Vasc Diffuse Lung Dis 2018; 35: 327-332) Mattioli 1885 2018 2018-12-05 /pmc/articles/PMC7170131/ /pubmed/32476920 http://dx.doi.org/10.36141/svdld.v35i4.7058 Text en Copyright: © 2018 http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution 4.0 International License
spellingShingle Original Article: Clinical Research
Catinon*, Mickael
Cavalin, Catherine
Chemarin, Cécile
Rio, Stéphane
Roux, Elisabeth
Pecquet, Mathieu
Blanchet, Anne-Sophie
Vuillermoz, Sylvie
Pison, Christophe
Arbib, François
Bonneterre, Vincent
Valeyre, Dominique
Freynet, Olivia
Mornex, Jean-François
Pacheco, Yves
Freymond, Nathalie
Thivolet, Françoise
Kambouchner, Marianne
Bernaudin, Jean-François
Nathalizio, Audrey
Pradat, Pierre
Rosental, Paul-André
Vincent, Michel
Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study
title Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study
title_full Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study
title_fullStr Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study
title_full_unstemmed Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study
title_short Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study
title_sort sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the minasarc pilot study
topic Original Article: Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170131/
https://www.ncbi.nlm.nih.gov/pubmed/32476920
http://dx.doi.org/10.36141/svdld.v35i4.7058
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