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Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study
Inhalation of mineral dust was suggested to contribute to sarcoidosis. We compared the mineral exposome of 20 sarcoidosis and 20 matched healthy subjects. Bronchoalveolar lavage (BAL) samples were treated by digestion-filtration and analyzed by transmission electron microscopy. The chemical composit...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mattioli 1885
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170131/ https://www.ncbi.nlm.nih.gov/pubmed/32476920 http://dx.doi.org/10.36141/svdld.v35i4.7058 |
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author | Catinon*, Mickael Cavalin, Catherine Chemarin, Cécile Rio, Stéphane Roux, Elisabeth Pecquet, Mathieu Blanchet, Anne-Sophie Vuillermoz, Sylvie Pison, Christophe Arbib, François Bonneterre, Vincent Valeyre, Dominique Freynet, Olivia Mornex, Jean-François Pacheco, Yves Freymond, Nathalie Thivolet, Françoise Kambouchner, Marianne Bernaudin, Jean-François Nathalizio, Audrey Pradat, Pierre Rosental, Paul-André Vincent, Michel |
author_facet | Catinon*, Mickael Cavalin, Catherine Chemarin, Cécile Rio, Stéphane Roux, Elisabeth Pecquet, Mathieu Blanchet, Anne-Sophie Vuillermoz, Sylvie Pison, Christophe Arbib, François Bonneterre, Vincent Valeyre, Dominique Freynet, Olivia Mornex, Jean-François Pacheco, Yves Freymond, Nathalie Thivolet, Françoise Kambouchner, Marianne Bernaudin, Jean-François Nathalizio, Audrey Pradat, Pierre Rosental, Paul-André Vincent, Michel |
author_sort | Catinon*, Mickael |
collection | PubMed |
description | Inhalation of mineral dust was suggested to contribute to sarcoidosis. We compared the mineral exposome of 20 sarcoidosis and 20 matched healthy subjects. Bronchoalveolar lavage (BAL) samples were treated by digestion-filtration and analyzed by transmission electron microscopy. The chemical composition of inorganic particles was determined by energy-dispersive X-ray (EDX) spectroscopy. Dust exposure was also assessed by a specific questionnaire. Eight sarcoidosis patients and five healthy volunteers had a high dust load in their BAL. No significant difference was observed between the overall inorganic particle load of each group while a significant higher load for steel was observed in sarcoidosis patients (p=0.029). Moreover, the building activity sub-score was significantly higher in sarcoidosis patients (p=0.018). These results suggest that building work could be a risk factor for sarcoidosis which could be considered at least in some cases as a granulomatosis caused by airborne inorganic dust. The questionnaire should be validated in larger studies. (Sarcoidosis Vasc Diffuse Lung Dis 2018; 35: 327-332) |
format | Online Article Text |
id | pubmed-7170131 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Mattioli 1885 |
record_format | MEDLINE/PubMed |
spelling | pubmed-71701312020-05-29 Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study Catinon*, Mickael Cavalin, Catherine Chemarin, Cécile Rio, Stéphane Roux, Elisabeth Pecquet, Mathieu Blanchet, Anne-Sophie Vuillermoz, Sylvie Pison, Christophe Arbib, François Bonneterre, Vincent Valeyre, Dominique Freynet, Olivia Mornex, Jean-François Pacheco, Yves Freymond, Nathalie Thivolet, Françoise Kambouchner, Marianne Bernaudin, Jean-François Nathalizio, Audrey Pradat, Pierre Rosental, Paul-André Vincent, Michel Sarcoidosis Vasc Diffuse Lung Dis Original Article: Clinical Research Inhalation of mineral dust was suggested to contribute to sarcoidosis. We compared the mineral exposome of 20 sarcoidosis and 20 matched healthy subjects. Bronchoalveolar lavage (BAL) samples were treated by digestion-filtration and analyzed by transmission electron microscopy. The chemical composition of inorganic particles was determined by energy-dispersive X-ray (EDX) spectroscopy. Dust exposure was also assessed by a specific questionnaire. Eight sarcoidosis patients and five healthy volunteers had a high dust load in their BAL. No significant difference was observed between the overall inorganic particle load of each group while a significant higher load for steel was observed in sarcoidosis patients (p=0.029). Moreover, the building activity sub-score was significantly higher in sarcoidosis patients (p=0.018). These results suggest that building work could be a risk factor for sarcoidosis which could be considered at least in some cases as a granulomatosis caused by airborne inorganic dust. The questionnaire should be validated in larger studies. (Sarcoidosis Vasc Diffuse Lung Dis 2018; 35: 327-332) Mattioli 1885 2018 2018-12-05 /pmc/articles/PMC7170131/ /pubmed/32476920 http://dx.doi.org/10.36141/svdld.v35i4.7058 Text en Copyright: © 2018 http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution 4.0 International License |
spellingShingle | Original Article: Clinical Research Catinon*, Mickael Cavalin, Catherine Chemarin, Cécile Rio, Stéphane Roux, Elisabeth Pecquet, Mathieu Blanchet, Anne-Sophie Vuillermoz, Sylvie Pison, Christophe Arbib, François Bonneterre, Vincent Valeyre, Dominique Freynet, Olivia Mornex, Jean-François Pacheco, Yves Freymond, Nathalie Thivolet, Françoise Kambouchner, Marianne Bernaudin, Jean-François Nathalizio, Audrey Pradat, Pierre Rosental, Paul-André Vincent, Michel Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study |
title | Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study |
title_full | Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study |
title_fullStr | Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study |
title_full_unstemmed | Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study |
title_short | Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study |
title_sort | sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the minasarc pilot study |
topic | Original Article: Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170131/ https://www.ncbi.nlm.nih.gov/pubmed/32476920 http://dx.doi.org/10.36141/svdld.v35i4.7058 |
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