Flattening filter free VMAT for a stereotactic, single‐dose of 30 Gy to lung lesion in a 15‐min treatment slot

Cone‐beam CT‐guided single dose of lung stereotactic body radiotherapy (SBRT) treatment with a flattening filter free (FFF) beam and volumetric modulated arc therapy (VMAT) is a safe and highly effective treatment modality for selective small lung lesions. Four‐dimensional (4D) CT‐based treatment pl...

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Autores principales: Pokhrel, Damodar, Sanford, Lana, Dhanireddy, Bhaswanth, Molloy, Janelle, Randall, Marcus, McGarry, Ronald C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Radiation Oncology Physics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170282/
https://www.ncbi.nlm.nih.gov/pubmed/32039544
http://dx.doi.org/10.1002/acm2.12829
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author Pokhrel, Damodar
Sanford, Lana
Dhanireddy, Bhaswanth
Molloy, Janelle
Randall, Marcus
McGarry, Ronald C.
author_facet Pokhrel, Damodar
Sanford, Lana
Dhanireddy, Bhaswanth
Molloy, Janelle
Randall, Marcus
McGarry, Ronald C.
author_sort Pokhrel, Damodar
collection PubMed
description Cone‐beam CT‐guided single dose of lung stereotactic body radiotherapy (SBRT) treatment with a flattening filter free (FFF) beam and volumetric modulated arc therapy (VMAT) is a safe and highly effective treatment modality for selective small lung lesions. Four‐dimensional (4D) CT‐based treatment plans were generated using advanced AcurosXB algorithm for heterogeneity corrections. 6X‐FFF beam produced highly conformal radiosurgical dose distribution to the target and reduced lung SBRT fraction duration to less than 10 min for a single dose of 30 Gy, significantly improving patient comfort and clinic workflow. Early follow‐up CT imaging results (mean, 8 months) show high local control rates (100%) with no acute lung or rib toxicity. Longer clinical follow‐up in a larger patient cohort managed in this fashion is underway to further validate this treatment approach.
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spelling pubmed-71702822020-04-21 Flattening filter free VMAT for a stereotactic, single‐dose of 30 Gy to lung lesion in a 15‐min treatment slot Pokhrel, Damodar Sanford, Lana Dhanireddy, Bhaswanth Molloy, Janelle Randall, Marcus McGarry, Ronald C. J Appl Clin Med Phys Radiation Oncology Physics Cone‐beam CT‐guided single dose of lung stereotactic body radiotherapy (SBRT) treatment with a flattening filter free (FFF) beam and volumetric modulated arc therapy (VMAT) is a safe and highly effective treatment modality for selective small lung lesions. Four‐dimensional (4D) CT‐based treatment plans were generated using advanced AcurosXB algorithm for heterogeneity corrections. 6X‐FFF beam produced highly conformal radiosurgical dose distribution to the target and reduced lung SBRT fraction duration to less than 10 min for a single dose of 30 Gy, significantly improving patient comfort and clinic workflow. Early follow‐up CT imaging results (mean, 8 months) show high local control rates (100%) with no acute lung or rib toxicity. Longer clinical follow‐up in a larger patient cohort managed in this fashion is underway to further validate this treatment approach. John Wiley and Sons Inc. 2020-02-10 /pmc/articles/PMC7170282/ /pubmed/32039544 http://dx.doi.org/10.1002/acm2.12829 Text en © 2020 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Pokhrel, Damodar
Sanford, Lana
Dhanireddy, Bhaswanth
Molloy, Janelle
Randall, Marcus
McGarry, Ronald C.
Flattening filter free VMAT for a stereotactic, single‐dose of 30 Gy to lung lesion in a 15‐min treatment slot
title Flattening filter free VMAT for a stereotactic, single‐dose of 30 Gy to lung lesion in a 15‐min treatment slot
title_full Flattening filter free VMAT for a stereotactic, single‐dose of 30 Gy to lung lesion in a 15‐min treatment slot
title_fullStr Flattening filter free VMAT for a stereotactic, single‐dose of 30 Gy to lung lesion in a 15‐min treatment slot
title_full_unstemmed Flattening filter free VMAT for a stereotactic, single‐dose of 30 Gy to lung lesion in a 15‐min treatment slot
title_short Flattening filter free VMAT for a stereotactic, single‐dose of 30 Gy to lung lesion in a 15‐min treatment slot
title_sort flattening filter free vmat for a stereotactic, single‐dose of 30 gy to lung lesion in a 15‐min treatment slot
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170282/
https://www.ncbi.nlm.nih.gov/pubmed/32039544
http://dx.doi.org/10.1002/acm2.12829
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