The selenium-containing drug ebselen potently disrupts LEDGF/p75-HIV-1 integrase interaction by targeting LEDGF/p75

Lens-epithelium-derived growth-factor (LEDGF/p75)-binding site on HIV-1 integrase (IN), is an attractive target for antiviral chemotherapy. Small-molecule compounds binding to this site are referred as LEDGF-IN inhibitors (LEDGINs). In this study, compound libraries were screened to identify new inh...

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Detalles Bibliográficos
Autores principales: Zhang, Da-Wei, Yan, Hao-Li, Xu, Xiao-Shuang, Xu, Lei, Yin, Zhi-Hui, Chang, Shan, Luo, Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170385/
https://www.ncbi.nlm.nih.gov/pubmed/32228103
http://dx.doi.org/10.1080/14756366.2020.1743282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170385/
https://www.ncbi.nlm.nih.gov/pubmed/32228103
http://dx.doi.org/10.1080/14756366.2020.1743282

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