Cargando…

The selenium-containing drug ebselen potently disrupts LEDGF/p75-HIV-1 integrase interaction by targeting LEDGF/p75

Lens-epithelium-derived growth-factor (LEDGF/p75)-binding site on HIV-1 integrase (IN), is an attractive target for antiviral chemotherapy. Small-molecule compounds binding to this site are referred as LEDGF-IN inhibitors (LEDGINs). In this study, compound libraries were screened to identify new inh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Da-Wei, Yan, Hao-Li, Xu, Xiao-Shuang, Xu, Lei, Yin, Zhi-Hui, Chang, Shan, Luo, Heng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170385/ https://www.ncbi.nlm.nih.gov/pubmed/32228103 http://dx.doi.org/10.1080/14756366.2020.1743282

Ejemplares similares

The Lentiviral Integrase Binding Protein LEDGF/p75 and HIV-1 Replication
por: Engelman, Alan, et al.
Publicado: (2008)

Modulation of the intrinsic chromatin binding property of HIV-1 integrase by LEDGF/p75
por: Lapaillerie, Delphine, et al.
Publicado: (2021)

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor
por: Wang, Hao, et al.
Publicado: (2012)

Analysis of LEDGF/p75 expression regulation
por: Desfarges, Sébastien, et al.
Publicado: (2009)

LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro
por: Cherepanov, Peter
Publicado: (2007)

HIV-1 integrase modulates the interaction of the HIV-1 cellular cofactor LEDGF/p75 with chromatin
por: Astiazaran, Paulina, et al.
Publicado: (2011)

LEDGIN-mediated Inhibition of Integrase–LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV
por: Vranckx, Lenard S., et al.
Publicado: (2016)

HIV-1 IN/Pol recruits LEDGF/p75 into viral particles
por: Desimmie, Belete Ayele, et al.
Publicado: (2015)

A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site
por: Maehigashi, Tatsuya, et al.
Publicado: (2021)

LEDGF/p75 Is Required for an Efficient DNA Damage Response
por: Liedtke, Victoria, et al.
Publicado: (2021)

Characterization of the HIV-1 integrase chromatin- and LEDGF/p75-binding abilities by mutagenic analysis within the catalytic core domain of integrase
por: Zheng, Yingfeng, et al.
Publicado: (2010)

LEDGF/p75 is critical but not essential for multiple-round HIV 1 replication
por: Schrijvers, RLG, et al.
Publicado: (2010)

Correction to: HIV-1 IN/Pol recruits LEDGF/p75 into viral particles
por: Desimmie, Belete Ayele, et al.
Publicado: (2020)

Molecular Modeling Study on the Allosteric Inhibition Mechanism of HIV-1 Integrase by LEDGF/p75 Binding Site Inhibitors
por: Xue, Weiwei, et al.
Publicado: (2014)

Efficient transduction of LEDGF/p75 mutant cells by complementary gain-of-function HIV-1 integrase mutant viruses
por: Wang, Hao, et al.
Publicado: (2014)

Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors
por: Singh, Parmit Kumar, et al.
Publicado: (2022)

Virus Evolution Reveals an Exclusive Role for LEDGF/p75 in Chromosomal Tethering of HIV
por: Hombrouck, Anneleen, et al.
Publicado: (2007)

LEDGF/p75 Proteins with Alternative Chromatin Tethers Are Functional HIV-1 Cofactors
por: Meehan, Anne M., et al.
Publicado: (2009)

Characterization of LEDGF/p75 Genetic Variants and Association with HIV-1 Disease Progression
por: Messiaen, Peter, et al.
Publicado: (2012)

LEDGF/p75 Deficiency Increases Deletions at the HIV-1 cDNA Ends
por: Bueno, Murilo T. D., et al.
Publicado: (2017)

Role of PSIP1/LEDGF/p75 in Lentiviral Infectivity and Integration Targeting
por: Marshall, Heather M., et al.
Publicado: (2007)

High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region
por: De Rijck, Jan, et al.
Publicado: (2010)

PB1704: LEDGF/P75 ASSOCIATED WITH CHEMORESISTANCE IN MIXED-LINEAGE LEUKEMIA
por: Akele, Muluembet, et al.
Publicado: (2023)

Evaluation of a flavonoid library for inhibition of interaction of HIV-1 integrase with human LEDGF/p75 towards a structure–activity relationship
por: Yin, Zhi-Hui, et al.
Publicado: (2022)

Studies on HIV integrase-LEDGF/p75 interaction inhibitory activity of isatine derivative using the alpha screen luminescent proximity assay
por: Selvam, Periyasamy
Publicado: (2012)

Dihydroxyphenyl- and Heteroaromatic-Based Thienopyrimidinones to Tackle HIV-1 LEDGF/p75-Dependent IN Activity
por: Tocco, Graziella, et al.
Publicado: (2023)

LEDGF/p75 IN interaction inhibitors: in silico studies of an old target with novel approach
por: Pant, Amit M, et al.
Publicado: (2014)

HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells
por: Schrijvers, Rik, et al.
Publicado: (2012)

The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells
por: Ortiz-Hernandez, Greisha L., et al.
Publicado: (2021)

A Novel Assay for Screening Inhibitors Targeting HIV Integrase LEDGF/p75 Interaction Based on Ni(2+) Coated Magnetic Agarose Beads
por: Dawei, Zhang, et al.
Publicado: (2016)

Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells
por: Levin, Aviad, et al.
Publicado: (2010)

FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75
por: Kessl, Jacques J., et al.
Publicado: (2011)

Targeting the stress oncoprotein LEDGF/p75 to sensitize chemoresistant prostate cancer cells to taxanes
por: Ríos-Colón, Leslimar, et al.
Publicado: (2017)

Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro
por: Botbol, Yaïr, et al.
Publicado: (2008)

LEDGF/p75 controls 3D-localization of HIV-1 provirus in the nuclear compartment of infected cells
por: Boll, Annegret, et al.
Publicado: (2013)

Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection
por: Lampi, Yulia, et al.
Publicado: (2019)

Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel DNA-binding domain
por: Tsutsui, Kimiko M., et al.
Publicado: (2011)

Glucocorticoid Receptor Regulates and Interacts with LEDGF/p75 to Promote Docetaxel Resistance in Prostate Cancer Cells
por: Sanchez-Hernandez, Evelyn S., et al.
Publicado: (2023)

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75
por: Hare, Stephen, et al.
Publicado: (2009)

LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes
por: Singh, Parmit Kumar, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_mu0a7ppvmo06d4k0qr7jechn74