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Serum vitamin K(1) associated to microangiopathy and/or macroangiopathy in individuals with and without diabetes

OBJECTIVE: Vitamin K has proposed beneficial effects on cardiovascular health. We investigated whether serum vitamin K(1) was associated with prevalence of microangiopathy and/or macroangiopathy. RESEARCH DESIGN AND METHODS: Serum vitamin K was quantified in 3239 individuals with and 3808 without di...

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Autores principales: Bøgh Andersen, Ida, Brasen, Claus Lohman, Nasimi, Hashmatullah, Stougård, Maria, Bliddal, Mette, Green, Anders, Schmedes, Anne, Brandslund, Ivan, Madsen, Jonna Skov
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170411/
https://www.ncbi.nlm.nih.gov/pubmed/32213490
http://dx.doi.org/10.1136/bmjdrc-2019-000961
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author Bøgh Andersen, Ida
Brasen, Claus Lohman
Nasimi, Hashmatullah
Stougård, Maria
Bliddal, Mette
Green, Anders
Schmedes, Anne
Brandslund, Ivan
Madsen, Jonna Skov
author_facet Bøgh Andersen, Ida
Brasen, Claus Lohman
Nasimi, Hashmatullah
Stougård, Maria
Bliddal, Mette
Green, Anders
Schmedes, Anne
Brandslund, Ivan
Madsen, Jonna Skov
author_sort Bøgh Andersen, Ida
collection PubMed
description OBJECTIVE: Vitamin K has proposed beneficial effects on cardiovascular health. We investigated whether serum vitamin K(1) was associated with prevalence of microangiopathy and/or macroangiopathy. RESEARCH DESIGN AND METHODS: Serum vitamin K was quantified in 3239 individuals with and 3808 without diabetes enrolled in Vejle Diabetes Biobank (2007–2010). Each individual was assessed for microangiography and macroangiopathy at enrollment based on registered diagnoses in the Danish National Patient Registry according to the International Classification of Disease 8 (1977–1993) and 10 (since 1994). Using multinomial logistic regression, relative risk ratios (RRRs) were calculated within each group of individuals with and without diabetes. RRRs were estimated for microangiopathic/macroangiopathic status compared with individuals without complications as a function of 1 nmol/L increments in K(1). Adjustment for potential confounders was also performed. RESULTS: Vitamin K(1) (median) varied 0.86–0.95 nmol/L depending on diabetes, microangiopathic and macroangiopathic status. In individuals with diabetes, the crude RRR for only having microangiopathy was 1.05 (95% CI 0.98 to 1.12) and was found significant when adjusting 1.10 (95% CI 1.01 to 1.19). RRR for having only macroangiopathy was 0.89 (95% CI 0.77 to 1.03) and was again significant when adjusting 0.79 (95% CI 0.66 to 0.96). In individuals without diabetes, adjustments again led to similar estimates that was not significant. The adjusted RRR for having only macroangiopathy was 1.08 (95% CI 0.98 to 1.19). CONCLUSIONS: Serum vitamin K(1) levels were associated with microangiopathic and macroangiopathic status in individuals with diabetes, but considered of no clinical relevance. The clinical value of other candidate markers for vitamin K status needs to be evaluated in future studies.
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spelling pubmed-71704112020-04-24 Serum vitamin K(1) associated to microangiopathy and/or macroangiopathy in individuals with and without diabetes Bøgh Andersen, Ida Brasen, Claus Lohman Nasimi, Hashmatullah Stougård, Maria Bliddal, Mette Green, Anders Schmedes, Anne Brandslund, Ivan Madsen, Jonna Skov BMJ Open Diabetes Res Care Cardiovascular and Metabolic Risk OBJECTIVE: Vitamin K has proposed beneficial effects on cardiovascular health. We investigated whether serum vitamin K(1) was associated with prevalence of microangiopathy and/or macroangiopathy. RESEARCH DESIGN AND METHODS: Serum vitamin K was quantified in 3239 individuals with and 3808 without diabetes enrolled in Vejle Diabetes Biobank (2007–2010). Each individual was assessed for microangiography and macroangiopathy at enrollment based on registered diagnoses in the Danish National Patient Registry according to the International Classification of Disease 8 (1977–1993) and 10 (since 1994). Using multinomial logistic regression, relative risk ratios (RRRs) were calculated within each group of individuals with and without diabetes. RRRs were estimated for microangiopathic/macroangiopathic status compared with individuals without complications as a function of 1 nmol/L increments in K(1). Adjustment for potential confounders was also performed. RESULTS: Vitamin K(1) (median) varied 0.86–0.95 nmol/L depending on diabetes, microangiopathic and macroangiopathic status. In individuals with diabetes, the crude RRR for only having microangiopathy was 1.05 (95% CI 0.98 to 1.12) and was found significant when adjusting 1.10 (95% CI 1.01 to 1.19). RRR for having only macroangiopathy was 0.89 (95% CI 0.77 to 1.03) and was again significant when adjusting 0.79 (95% CI 0.66 to 0.96). In individuals without diabetes, adjustments again led to similar estimates that was not significant. The adjusted RRR for having only macroangiopathy was 1.08 (95% CI 0.98 to 1.19). CONCLUSIONS: Serum vitamin K(1) levels were associated with microangiopathic and macroangiopathic status in individuals with diabetes, but considered of no clinical relevance. The clinical value of other candidate markers for vitamin K status needs to be evaluated in future studies. BMJ Publishing Group 2020-03-25 /pmc/articles/PMC7170411/ /pubmed/32213490 http://dx.doi.org/10.1136/bmjdrc-2019-000961 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Cardiovascular and Metabolic Risk
Bøgh Andersen, Ida
Brasen, Claus Lohman
Nasimi, Hashmatullah
Stougård, Maria
Bliddal, Mette
Green, Anders
Schmedes, Anne
Brandslund, Ivan
Madsen, Jonna Skov
Serum vitamin K(1) associated to microangiopathy and/or macroangiopathy in individuals with and without diabetes
title Serum vitamin K(1) associated to microangiopathy and/or macroangiopathy in individuals with and without diabetes
title_full Serum vitamin K(1) associated to microangiopathy and/or macroangiopathy in individuals with and without diabetes
title_fullStr Serum vitamin K(1) associated to microangiopathy and/or macroangiopathy in individuals with and without diabetes
title_full_unstemmed Serum vitamin K(1) associated to microangiopathy and/or macroangiopathy in individuals with and without diabetes
title_short Serum vitamin K(1) associated to microangiopathy and/or macroangiopathy in individuals with and without diabetes
title_sort serum vitamin k(1) associated to microangiopathy and/or macroangiopathy in individuals with and without diabetes
topic Cardiovascular and Metabolic Risk
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170411/
https://www.ncbi.nlm.nih.gov/pubmed/32213490
http://dx.doi.org/10.1136/bmjdrc-2019-000961
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