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Regional Incidence of Inflammatory Bowel Disease in a Czech Pediatric Population: 16 Years of Experience (2002–2017)

OBJECTIVES: Inflammatory bowel disease (IBD) is today a global disease, the incidence of which is growing in the pediatric population. This prospective study aims to decipher IBD incidence and its trend in a pediatric population through 16 years in the South Moravian Region of the Czech Republic. ME...

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Autores principales: Jabandziev, Petr, Pinkasova, Tereza, Kunovsky, Lumir, Papez, Jan, Jouza, Martin, Karlinova, Bara, Novackova, Martina, Urik, Milan, Aulicka, Stefania, Slaby, Ondrej, Bohosova, Julia, Bajerova, Katerina, Bajer, Milan, Goel, Ajay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170436/
https://www.ncbi.nlm.nih.gov/pubmed/32058417
http://dx.doi.org/10.1097/MPG.0000000000002660
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author Jabandziev, Petr
Pinkasova, Tereza
Kunovsky, Lumir
Papez, Jan
Jouza, Martin
Karlinova, Bara
Novackova, Martina
Urik, Milan
Aulicka, Stefania
Slaby, Ondrej
Bohosova, Julia
Bajerova, Katerina
Bajer, Milan
Goel, Ajay
author_facet Jabandziev, Petr
Pinkasova, Tereza
Kunovsky, Lumir
Papez, Jan
Jouza, Martin
Karlinova, Bara
Novackova, Martina
Urik, Milan
Aulicka, Stefania
Slaby, Ondrej
Bohosova, Julia
Bajerova, Katerina
Bajer, Milan
Goel, Ajay
author_sort Jabandziev, Petr
collection PubMed
description OBJECTIVES: Inflammatory bowel disease (IBD) is today a global disease, the incidence of which is growing in the pediatric population. This prospective study aims to decipher IBD incidence and its trend in a pediatric population through 16 years in the South Moravian Region of the Czech Republic. METHODS: We evaluated data concerning 358 pediatric patients with newly diagnosed IBD at University Hospital Brno, which is a gastroenterology center for the entire pediatric population (0–18 years) and cares for all pediatric IBD patients in the South Moravian Region (1,187,667 inhabitants). RESULTS: The study encompassed 3,488,907 children during 16 years. We diagnosed 192 children (53.6%) with Crohn disease (CD), 123 (34.4%) with ulcerative colitis (UC), and 43 (12.0%) with IBD-unclassified (IBD-U). The incidence of IBD increased from 3.8 (CD 2.9, UC 0.9, and IBD-U 0.0) per 100 000/year in 2002 to 14.7 (CD 9.8, UC 4.0, and IBD-U 0.9) per 100,000/year in 2017 (P < 0.001). The overall IBD incidence per 100,000/year was 9.8 (95% confidence interval [CI]: 8.8--10.9). Constituent incidences per 100,000/year were CD 5.2 (95% CI: 4.5--6.0), UC 3.4 (95% CI: 2.8--4.0), and IBD-U 1.2 (95% CI: 0.9--1.6). IBD incidence was projected to reach 18.9 per 100,000/year in 2022. CONCLUSIONS: The overall incidence of pediatric IBD in the Czech Republic is increasing, and especially that of CD, whereas trends in UC and IBD-U appear to be constant. These data highlight the need to identify risk factors involved in the rising incidence of IBD.
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spelling pubmed-71704362020-05-04 Regional Incidence of Inflammatory Bowel Disease in a Czech Pediatric Population: 16 Years of Experience (2002–2017) Jabandziev, Petr Pinkasova, Tereza Kunovsky, Lumir Papez, Jan Jouza, Martin Karlinova, Bara Novackova, Martina Urik, Milan Aulicka, Stefania Slaby, Ondrej Bohosova, Julia Bajerova, Katerina Bajer, Milan Goel, Ajay J Pediatr Gastroenterol Nutr Original Articles: Gastroenterology: Inflammatory Bowel Disease OBJECTIVES: Inflammatory bowel disease (IBD) is today a global disease, the incidence of which is growing in the pediatric population. This prospective study aims to decipher IBD incidence and its trend in a pediatric population through 16 years in the South Moravian Region of the Czech Republic. METHODS: We evaluated data concerning 358 pediatric patients with newly diagnosed IBD at University Hospital Brno, which is a gastroenterology center for the entire pediatric population (0–18 years) and cares for all pediatric IBD patients in the South Moravian Region (1,187,667 inhabitants). RESULTS: The study encompassed 3,488,907 children during 16 years. We diagnosed 192 children (53.6%) with Crohn disease (CD), 123 (34.4%) with ulcerative colitis (UC), and 43 (12.0%) with IBD-unclassified (IBD-U). The incidence of IBD increased from 3.8 (CD 2.9, UC 0.9, and IBD-U 0.0) per 100 000/year in 2002 to 14.7 (CD 9.8, UC 4.0, and IBD-U 0.9) per 100,000/year in 2017 (P < 0.001). The overall IBD incidence per 100,000/year was 9.8 (95% confidence interval [CI]: 8.8--10.9). Constituent incidences per 100,000/year were CD 5.2 (95% CI: 4.5--6.0), UC 3.4 (95% CI: 2.8--4.0), and IBD-U 1.2 (95% CI: 0.9--1.6). IBD incidence was projected to reach 18.9 per 100,000/year in 2022. CONCLUSIONS: The overall incidence of pediatric IBD in the Czech Republic is increasing, and especially that of CD, whereas trends in UC and IBD-U appear to be constant. These data highlight the need to identify risk factors involved in the rising incidence of IBD. Lippincott Williams & Wilkins 2020-05 2020-02-12 /pmc/articles/PMC7170436/ /pubmed/32058417 http://dx.doi.org/10.1097/MPG.0000000000002660 Text en Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle Original Articles: Gastroenterology: Inflammatory Bowel Disease
Jabandziev, Petr
Pinkasova, Tereza
Kunovsky, Lumir
Papez, Jan
Jouza, Martin
Karlinova, Bara
Novackova, Martina
Urik, Milan
Aulicka, Stefania
Slaby, Ondrej
Bohosova, Julia
Bajerova, Katerina
Bajer, Milan
Goel, Ajay
Regional Incidence of Inflammatory Bowel Disease in a Czech Pediatric Population: 16 Years of Experience (2002–2017)
title Regional Incidence of Inflammatory Bowel Disease in a Czech Pediatric Population: 16 Years of Experience (2002–2017)
title_full Regional Incidence of Inflammatory Bowel Disease in a Czech Pediatric Population: 16 Years of Experience (2002–2017)
title_fullStr Regional Incidence of Inflammatory Bowel Disease in a Czech Pediatric Population: 16 Years of Experience (2002–2017)
title_full_unstemmed Regional Incidence of Inflammatory Bowel Disease in a Czech Pediatric Population: 16 Years of Experience (2002–2017)
title_short Regional Incidence of Inflammatory Bowel Disease in a Czech Pediatric Population: 16 Years of Experience (2002–2017)
title_sort regional incidence of inflammatory bowel disease in a czech pediatric population: 16 years of experience (2002–2017)
topic Original Articles: Gastroenterology: Inflammatory Bowel Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170436/
https://www.ncbi.nlm.nih.gov/pubmed/32058417
http://dx.doi.org/10.1097/MPG.0000000000002660
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