Prolonged glucosuria and relapse of diabetic ketoacidosis related to SGLT2‐inhibitor therapy

SGLT2 inhibitors (SGLT2i) are glucose‐lowering medications which increase the renal threshold for glucose reabsorption and promote glucosuria. Treatment with these agents raises serum ketone levels, and cases of diabetic ketoacidosis (DKA) during therapy have been reported. The duration of glucosuri...

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Autores principales: Westcott, Gregory P., Segal, Alissa R., Mitri, Joanna, Brown, Florence M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170458/
https://www.ncbi.nlm.nih.gov/pubmed/32318635
http://dx.doi.org/10.1002/edm2.117
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author Westcott, Gregory P.
Segal, Alissa R.
Mitri, Joanna
Brown, Florence M.
author_facet Westcott, Gregory P.
Segal, Alissa R.
Mitri, Joanna
Brown, Florence M.
author_sort Westcott, Gregory P.
collection PubMed
description SGLT2 inhibitors (SGLT2i) are glucose‐lowering medications which increase the renal threshold for glucose reabsorption and promote glucosuria. Treatment with these agents raises serum ketone levels, and cases of diabetic ketoacidosis (DKA) during therapy have been reported. The duration of glucosuria and inpatient course of SGLT2i‐related DKA, however, is not well‐characterized. We report 11 inpatient cases of SGLT2i‐related DKA, including a subset of patients who experienced prolonged glucosuria and relapse of DKA during their hospitalization.
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spelling pubmed-71704582020-04-21 Prolonged glucosuria and relapse of diabetic ketoacidosis related to SGLT2‐inhibitor therapy Westcott, Gregory P. Segal, Alissa R. Mitri, Joanna Brown, Florence M. Endocrinol Diabetes Metab Case Reports SGLT2 inhibitors (SGLT2i) are glucose‐lowering medications which increase the renal threshold for glucose reabsorption and promote glucosuria. Treatment with these agents raises serum ketone levels, and cases of diabetic ketoacidosis (DKA) during therapy have been reported. The duration of glucosuria and inpatient course of SGLT2i‐related DKA, however, is not well‐characterized. We report 11 inpatient cases of SGLT2i‐related DKA, including a subset of patients who experienced prolonged glucosuria and relapse of DKA during their hospitalization. John Wiley and Sons Inc. 2020-02-29 /pmc/articles/PMC7170458/ /pubmed/32318635 http://dx.doi.org/10.1002/edm2.117 Text en © 2020 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Westcott, Gregory P.
Segal, Alissa R.
Mitri, Joanna
Brown, Florence M.
Prolonged glucosuria and relapse of diabetic ketoacidosis related to SGLT2‐inhibitor therapy
title Prolonged glucosuria and relapse of diabetic ketoacidosis related to SGLT2‐inhibitor therapy
title_full Prolonged glucosuria and relapse of diabetic ketoacidosis related to SGLT2‐inhibitor therapy
title_fullStr Prolonged glucosuria and relapse of diabetic ketoacidosis related to SGLT2‐inhibitor therapy
title_full_unstemmed Prolonged glucosuria and relapse of diabetic ketoacidosis related to SGLT2‐inhibitor therapy
title_short Prolonged glucosuria and relapse of diabetic ketoacidosis related to SGLT2‐inhibitor therapy
title_sort prolonged glucosuria and relapse of diabetic ketoacidosis related to sglt2‐inhibitor therapy
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170458/
https://www.ncbi.nlm.nih.gov/pubmed/32318635
http://dx.doi.org/10.1002/edm2.117
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