Repression of sphingosine kinase (SK)-interacting protein (SKIP) in acute myeloid leukemia diminishes SK activity and its re-expression restores SK function

Previous studies have shown that sphingosine kinase interacting protein (SKIP) inhibits sphingosine kinase (SK) function in fibroblasts. SK phosphorylates sphingosine producing the potent signaling molecule sphingosine-1-phosphate (S1P). SKIP gene (SPHKAP) expression is silenced by hypermethylation...

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Detalles Bibliográficos
Autores principales: Ghazaly, Essam A., Miraki-Moud, Farideh, Smith, Paul, Gnanaranjan, Chathunissa, Koniali, Lola, Oke, Adedayo, Saied, Marwa H., Petty, Robert, Matthews, Janet, Stronge, Randal, Joel, Simon P., Young, Bryan D., Gribben, John, Taussig, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170527/
https://www.ncbi.nlm.nih.gov/pubmed/32161116
http://dx.doi.org/10.1074/jbc.RA119.010467

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