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Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015

Myostatin (or growth/differentiation factor 8 (GDF8)) is a member of the transforming growth factor β superfamily of growth factors and negatively regulates skeletal muscle growth. Its dysregulation is implicated in muscle wasting diseases. SRK-015 is a clinical-stage mAb that prevents extracellular...

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Detalles Bibliográficos
Autores principales:	Dagbay, Kevin B., Treece, Erin, Streich, Frederick C., Jackson, Justin W., Faucette, Ryan R., Nikiforov, Anastasia, Lin, Susan C., Boston, Chris J., Nicholls, Samantha B., Capili, Allan D., Carven, Gregory J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170532/ https://www.ncbi.nlm.nih.gov/pubmed/32075906 http://dx.doi.org/10.1074/jbc.RA119.012293

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