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Cohort profile: the Brain and Mind Centre Optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcare

PURPOSE: The Brain and Mind Centre (BMC) Optymise cohort assesses multiple clinical and functional domains longitudinally in young people presenting for mental health care and treatment. Longitudinal tracking of this cohort will allow investigation of the relationships between multiple outcome domai...

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Autores principales: Carpenter, Joanne S, Iorfino, Frank, Cross, Shane, Nichles, Alissa, Zmicerevska, Natalia, Crouse, Jacob J, Palmer, Jake R, Whitton, Alexis E, White, Django, Naismith, Sharon L, Guastella, Adam J, Hermens, Daniel F, Scott, Jan, Scott, Elizabeth M, Hickie, Ian B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170572/
https://www.ncbi.nlm.nih.gov/pubmed/32229519
http://dx.doi.org/10.1136/bmjopen-2019-030985
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author Carpenter, Joanne S
Iorfino, Frank
Cross, Shane
Nichles, Alissa
Zmicerevska, Natalia
Crouse, Jacob J
Palmer, Jake R
Whitton, Alexis E
White, Django
Naismith, Sharon L
Guastella, Adam J
Hermens, Daniel F
Scott, Jan
Scott, Elizabeth M
Hickie, Ian B
author_facet Carpenter, Joanne S
Iorfino, Frank
Cross, Shane
Nichles, Alissa
Zmicerevska, Natalia
Crouse, Jacob J
Palmer, Jake R
Whitton, Alexis E
White, Django
Naismith, Sharon L
Guastella, Adam J
Hermens, Daniel F
Scott, Jan
Scott, Elizabeth M
Hickie, Ian B
author_sort Carpenter, Joanne S
collection PubMed
description PURPOSE: The Brain and Mind Centre (BMC) Optymise cohort assesses multiple clinical and functional domains longitudinally in young people presenting for mental health care and treatment. Longitudinal tracking of this cohort will allow investigation of the relationships between multiple outcome domains across the course of care. Subsets of Optymise have completed detailed neuropsychological and neurobiological assessments, permitting investigation of associations between these measures and longitudinal course. PARTICIPANTS: Young people (aged 12–30) presenting to clinics coordinated by the BMC were recruited to a research register (n=6743) progressively between June 2008 and July 2018. To date, 2767 individuals have been included in Optymise based on the availability of at least one detailed clinical assessment. MEASURES: Trained researchers use a clinical research proforma to extract key data from clinical files to detail social and occupational functioning, clinical presentation, self-harm and suicidal thoughts and behaviours, alcohol and other substance use, physical health comorbidities, personal and family history of mental illness, and treatment utilisation at the following time points: baseline, 3, 6, 12, 24, 36, 48, and 60 months, and time last seen. FINDINGS TO DATE: There is moderate to substantial agreement between raters for data collected via the proforma. While wide variations in individual illness course are clear, social and occupational outcomes suggest that the majority of cohort members show no improvement in functioning over time. Differential rates of longitudinal transition are reported between early and late stages of illness, with a number of baseline factors associated with these transitions. Furthermore, there are longitudinal associations between prior suicide attempts and inferior clinical and functional outcomes. FUTURE PLANS: Future reports will detail the longitudinal course of each outcome domain and examine multidirectional relationships between these domains both cross-sectionally and longitudinally, and explore in subsets the associations between detailed neurobiological measures and clinical, social and functional outcomes.
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spelling pubmed-71705722020-04-24 Cohort profile: the Brain and Mind Centre Optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcare Carpenter, Joanne S Iorfino, Frank Cross, Shane Nichles, Alissa Zmicerevska, Natalia Crouse, Jacob J Palmer, Jake R Whitton, Alexis E White, Django Naismith, Sharon L Guastella, Adam J Hermens, Daniel F Scott, Jan Scott, Elizabeth M Hickie, Ian B BMJ Open Mental Health PURPOSE: The Brain and Mind Centre (BMC) Optymise cohort assesses multiple clinical and functional domains longitudinally in young people presenting for mental health care and treatment. Longitudinal tracking of this cohort will allow investigation of the relationships between multiple outcome domains across the course of care. Subsets of Optymise have completed detailed neuropsychological and neurobiological assessments, permitting investigation of associations between these measures and longitudinal course. PARTICIPANTS: Young people (aged 12–30) presenting to clinics coordinated by the BMC were recruited to a research register (n=6743) progressively between June 2008 and July 2018. To date, 2767 individuals have been included in Optymise based on the availability of at least one detailed clinical assessment. MEASURES: Trained researchers use a clinical research proforma to extract key data from clinical files to detail social and occupational functioning, clinical presentation, self-harm and suicidal thoughts and behaviours, alcohol and other substance use, physical health comorbidities, personal and family history of mental illness, and treatment utilisation at the following time points: baseline, 3, 6, 12, 24, 36, 48, and 60 months, and time last seen. FINDINGS TO DATE: There is moderate to substantial agreement between raters for data collected via the proforma. While wide variations in individual illness course are clear, social and occupational outcomes suggest that the majority of cohort members show no improvement in functioning over time. Differential rates of longitudinal transition are reported between early and late stages of illness, with a number of baseline factors associated with these transitions. Furthermore, there are longitudinal associations between prior suicide attempts and inferior clinical and functional outcomes. FUTURE PLANS: Future reports will detail the longitudinal course of each outcome domain and examine multidirectional relationships between these domains both cross-sectionally and longitudinally, and explore in subsets the associations between detailed neurobiological measures and clinical, social and functional outcomes. BMJ Publishing Group 2020-03-29 /pmc/articles/PMC7170572/ /pubmed/32229519 http://dx.doi.org/10.1136/bmjopen-2019-030985 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Mental Health
Carpenter, Joanne S
Iorfino, Frank
Cross, Shane
Nichles, Alissa
Zmicerevska, Natalia
Crouse, Jacob J
Palmer, Jake R
Whitton, Alexis E
White, Django
Naismith, Sharon L
Guastella, Adam J
Hermens, Daniel F
Scott, Jan
Scott, Elizabeth M
Hickie, Ian B
Cohort profile: the Brain and Mind Centre Optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcare
title Cohort profile: the Brain and Mind Centre Optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcare
title_full Cohort profile: the Brain and Mind Centre Optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcare
title_fullStr Cohort profile: the Brain and Mind Centre Optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcare
title_full_unstemmed Cohort profile: the Brain and Mind Centre Optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcare
title_short Cohort profile: the Brain and Mind Centre Optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcare
title_sort cohort profile: the brain and mind centre optymise cohort: tracking multidimensional outcomes in young people presenting for mental healthcare
topic Mental Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170572/
https://www.ncbi.nlm.nih.gov/pubmed/32229519
http://dx.doi.org/10.1136/bmjopen-2019-030985
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