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A molecular view on the escape of lipoplexed DNA from the endosome

The use of non-viral vectors for in vivo gene therapy could drastically increase safety, whilst reducing the cost of preparing the vectors. A promising approach to non-viral vectors makes use of DNA/cationic liposome complexes (lipoplexes) to deliver the genetic material. Here we use coarse-grained...

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Detalles Bibliográficos
Autores principales:	Bruininks, Bart MH, Souza, Paulo CT, Ingolfsson, Helgi, Marrink, Siewert J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Computational and Systems Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170654/ https://www.ncbi.nlm.nih.gov/pubmed/32297853 http://dx.doi.org/10.7554/eLife.52012

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