Cargando…

KIT ligand protects against both light-induced and genetic photoreceptor degeneration

Photoreceptor degeneration is a major cause of blindness and a considerable health burden during aging but effective therapeutic or preventive strategies have not so far become readily available. Here, we show in mouse models that signaling through the tyrosine kinase receptor KIT protects photorece...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Huirong, Lian, Lili, Liu, Bo, Chen, Yu, Yang, Jinglei, Jian, Shuhui, Zhou, Jiajia, Xu, Ying, Ma, Xiaoyin, Qu, Jia, Hou, Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170656/ https://www.ncbi.nlm.nih.gov/pubmed/32242818 http://dx.doi.org/10.7554/eLife.51698

Ejemplares similares

MITF protects against oxidative damage-induced retinal degeneration by regulating the NRF2 pathway in the retinal pigment epithelium
por: Han, Shuxian, et al.
Publicado: (2020)

Photoreceptor degeneration in microphthalmia (Mitf) mice: partial rescue by pigment epithelium-derived factor
por: Chen, Yu, et al.
Publicado: (2019)

High dose expression of heme oxigenase-1 induces retinal degeneration through ER stress-related DDIT3
por: Li, Huirong, et al.
Publicado: (2021)

Haploinsufficiency of GCP4 induces autophagy and leads to photoreceptor degeneration due to defective spindle assembly in retina
por: Li, Zhigang, et al.
Publicado: (2019)

Endothelin-2-Mediated Protection of Mutant Photoreceptors in Inherited Photoreceptor Degeneration
por: Bramall, Alexa N., et al.
Publicado: (2013)

Non-erythropoietic erythropoietin derivatives protect from light-induced and genetic photoreceptor degeneration
por: Colella, Pasqualina, et al.
Publicado: (2011)

Endogenous leukemia inhibitory factor protects photoreceptor cells against light-induced degeneration
por: Bürgi, Sandra, et al.
Publicado: (2009)

Sortilin Participates in Light-dependent Photoreceptor Degeneration in Vivo
por: Santos, Ana M., et al.
Publicado: (2012)

Sensitivity of the Dorsal-Central Retinal Pigment Epithelium to Sodium Iodate-Induced Damage Is Associated With Overlying M-Cone Photoreceptors in Mice
por: Lian, Lili, et al.
Publicado: (2022)

Retinal Pre-Conditioning by CD59a Knockout Protects against Light-Induced Photoreceptor Degeneration
por: Song, Delu, et al.
Publicado: (2016)

Cytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration
por: Chen, Xinping, et al.
Publicado: (2017)

Intraperitoneal injection of (−)-Epigallocatechin-3-gallate protects against light-induced photoreceptor degeneration in the mouse retina
por: Qi, Shounan, et al.
Publicado: (2017)

Secondary Photoreceptor Degenerations
por: Gorin, M.B.
Publicado: (2010)

Hyperoside protects against oxidative stress-mediated photoreceptor degeneration: therapeutic potentials for photoreceptor degenerative diseases
por: Li, Daijin, et al.
Publicado: (2023)

Adaptation to constant light requires Fic-mediated AMPylation of BiP to protect against reversible photoreceptor degeneration
por: Moehlman, Andrew T, et al.
Publicado: (2018)

Cuscuta chinensis Lam. Protects Against Light-Induced Retinal Degeneration: Therapeutic Implications for Photoreceptor Degenerative Disorders
por: Wu, Hanhan, et al.
Publicado: (2022)

The novel visual cycle inhibitor (±)-RPE65-61 protects retinal photoreceptors from light-induced degeneration
por: Wang, Yuhong, et al.
Publicado: (2022)

Metformin treatment confers protection of the optic nerve following photoreceptor degeneration
por: Eltony, Sohair A., et al.
Publicado: (2021)

Photoreceptor damage induced by low-intensity light: model of retinal degeneration in mammals
por: Contín, Maria Ana, et al.
Publicado: (2013)

Photobiomodulation Mediates Neuroprotection against Blue Light Induced Retinal Photoreceptor Degeneration
por: Heinig, Nora, et al.
Publicado: (2020)

Synaptic changes and the response of microglia in a light-induced photoreceptor degeneration model
por: Xu, Sisi, et al.
Publicado: (2021)

An empty E1(−), E3(−), E4(−) adenovirus vector protects photoreceptors from light-induced degeneration
por: Takita, Hiroyasu, et al.
Publicado: (2008)

Modulation of recognition memory performance by light requires both melanopsin and classical photoreceptors
por: Tam, Shu K. E., et al.
Publicado: (2016)

Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress
por: Jaiswal, Manish, et al.
Publicado: (2015)

Inhibition of mTOR signaling by rapamycin protects photoreceptors from degeneration in rd1 mice
por: Yang, Jia-Liang, et al.
Publicado: (2021)

Light-induced photoreceptor and RPE degeneration involve zinc toxicity and are attenuated by pyruvate, nicotinamide, or cyclic light
por: Sheline, Christian T., et al.
Publicado: (2010)

Surface Modification by Amino Group Inducing for Highly Efficient Catalytic Oxidation of Toluene over a Pd/KIT-6 Catalyst
por: Cui, Jinglei, et al.
Publicado: (2022)

Genetics of photoreceptor degeneration and regeneration in zebrafish
por: Brockerhoff, Susan E., et al.
Publicado: (2010)

Role of microglial cells in photoreceptor degeneration
por: Di Pierdomenico, Johnny, et al.
Publicado: (2019)

Zebrafish Models of Photoreceptor Dysfunction and Degeneration
por: Noel, Nicole C. L., et al.
Publicado: (2021)

cGMP Signaling in Photoreceptor Degeneration
por: Li, Shujuan, et al.
Publicado: (2023)

Correction: Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress
por: Jaiswal, Manish, et al.
Publicado: (2018)

Photoreceptor protection via blockade of BET epigenetic readers in a murine model of inherited retinal degeneration
por: Zhao, Lei, et al.
Publicado: (2017)

Platinum Nanozymes Counteract Photoreceptor Degeneration and Retina Inflammation in a Light-Damage Model of Age-Related Macular Degeneration
por: Cupini, Sara, et al.
Publicado: (2023)

A conventional PKC critical for both the light-dependent and the light-independent regulation of the actin cytoskeleton in Drosophila photoreceptors
por: Shieh, Bih-Hwa, et al.
Publicado: (2023)

Retinal Ganglion Cells are Resistant to Photoreceptor Loss in Retinal Degeneration
por: Lin, Bin, et al.
Publicado: (2013)

Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration
por: Zhao, Lian, et al.
Publicado: (2015)

Loss of Tmem30a leads to photoreceptor degeneration
por: Zhang, Lin, et al.
Publicado: (2017)

Increased Light Exposure Alleviates One Form of Photoreceptor Degeneration Marked by Elevated Calcium in the Dark
por: Liu, Xiaoqing, et al.
Publicado: (2009)

Light Stress-Induced Increase of Sphingosine 1-Phosphate in Photoreceptors and Its Relevance to Retinal Degeneration
por: Terao, Ryo, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3oeol3p0l2a4fbbijj9a5dl5v4